{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:18:56Z","timestamp":1783621136508,"version":"3.55.0"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG091414"],"award-info":[{"award-number":["1R01AG091414"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Urban heat islands (UHIs) are areas of elevated surface temperature caused by limited vegetation and dense development. Extreme heat disproportionately affects older adults and may increase risk for Alzheimer\u2019s disease (AD) and related dementias (ADRD), but few studies have examined whether cumulative neighborhood-level heat exposure is associated with cognitive decline or ADRD biomarkers. This study will investigate whether recent UHI exposure is associated with cognitive function; determine whether cumulative UHI exposure is associated with cognitive decline, plasma ADRD biomarkers, and brain imaging biomarkers; and evaluate whether UHI exposure is associated with ADRD risk factors, including physical inactivity, social isolation, and inflammation, and whether tree canopy mitigates heat-ADRD associations. The study includes 500 adults aged \u226550 years from the Healthy Brain Initiative cohort in South Florida. Geocoded residential addresses will be linked to satellite-derived land surface temperature data to quantify recent exposure at the baseline cognitive visit and cumulative exposure during the month before, and 1 and 5 years before baseline. Participants complete annual clinical and neuropsychological assessments, brain MRI, and blood collection for ADRD biomarkers. A sub-sample of 200 participants will wear smartwatches during two 3-week periods to capture GPS-based heat exposure, physical activity, and daily cognitive testing. Analyses will be replicated using the nationally representative Health and Retirement Study. Primary outcomes include cognitive domain scores, brain imaging measures, and preclinical AD status determined from plasma biomarkers. This study will provide comprehensive data on cumulative UHI exposure and ADRD risk by integrating cognitive assessment, neuroimaging, and biomarkers. Findings will clarify whether neighborhood heat represents a modifiable ADRD risk factor and inform urban greening and brain health promotion strategies.<\/jats:p>","DOI":"10.1371\/journal.pone.0350611","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:37:58Z","timestamp":1783618678000},"page":"e0350611","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The heat exposure, aging trajectories, and Alzheimer\u2019s disease (HEAT-AD) study protocol"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3313-7655","authenticated-orcid":true,"given":"Deirdre 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and heat extremes: health risks","volume":"398","author":"KL Ebi","year":"2021","journal-title":"Lancet"},{"issue":"11","key":"pone.0350611.ref008","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/jech-2023-220675","article-title":"Cumulative exposure to extreme heat and trajectories of cognitive decline among older adults in the USA","volume":"77","author":"EY Choi","year":"2023","journal-title":"J Epidemiol Community Health"},{"key":"pone.0350611.ref009","volume-title":"Compendium of WHO and other UN guidance in health and environment, 2024 update","author":"World Health Organization","year":"2024"},{"issue":"3","key":"pone.0350611.ref010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s40471-014-0014-4","article-title":"Racial and socioeconomic disparities in heat-related health effects and their mechanisms: a review","volume":"1","author":"CJ Gronlund","year":"2014","journal-title":"Curr Epidemiol 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(Basel)"},{"key":"pone.0350611.ref014","doi-asserted-by":"crossref","first-page":"141588","DOI":"10.1016\/j.scitotenv.2020.141588","article-title":"Air temperature variability and high-sensitivity C reactive protein in a general population of China","volume":"749","author":"Y Kang","year":"2020","journal-title":"Sci Total Environ"},{"issue":"8","key":"pone.0350611.ref015","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1017\/S0033291717003130","article-title":"High-sensitivity C-reactive protein and cognitive decline: the English longitudinal study of ageing","volume":"48","author":"F Zheng","year":"2018","journal-title":"Psychol Med"},{"key":"pone.0350611.ref016","doi-asserted-by":"crossref","first-page":"1087571","DOI":"10.3389\/fimmu.2023.1087571","article-title":"A meta-analysis investigating the relationship between inflammation in autoimmune disease, elevated CRP, and the risk of dementia","volume":"14","author":"J Cooper","year":"2023","journal-title":"Front 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National environmental public health tracking. Accessed 2026 April 14. https:\/\/www.cdc.gov\/nceh\/tracking\/index.html"},{"key":"pone.0350611.ref041","unstructured":"USDA Forest Service. USFS tree canopy cover datasets. Accessed 2024 March 2. https:\/\/data.fs.usda.gov\/geodata\/rastergateway\/treecanopycover\/"},{"key":"pone.0350611.ref042","unstructured":"National Oceanic and Atmospheric Administration. What is lidar?. https:\/\/oceanservice.noaa.gov\/facts\/lidar.html. 2023. 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ADNI 3. 2017. Accessed 2023 October 29. https:\/\/adni.loni.usc.edu\/adni-3\/"},{"issue":"9","key":"pone.0350611.ref058","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1007\/s00330-019-06067-1","article-title":"Automatically computed rating scales from MRI for patients with cognitive disorders","volume":"29","author":"JR Koikkalainen","year":"2019","journal-title":"Eur Radiol"},{"issue":"12","key":"pone.0350611.ref059","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s00234-021-02761-4","article-title":"A novel CT-based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions","volume":"63","author":"AL Kaipainen","year":"2021","journal-title":"Neuroradiology"},{"issue":"49","key":"pone.0350611.ref060","doi-asserted-by":"crossref","first-page":"20954","DOI":"10.1073\/pnas.0906053106","article-title":"Subregional neuroanatomical change as a biomarker for Alzheimer\u2019s disease","volume":"106","author":"Alzheimer\u2019s Disease Neuroimaging Initiative","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pone.0350611.ref061","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/cercor\/bhn113","article-title":"The cortical signature of Alzheimer\u2019s disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals","volume":"19","author":"BC Dickerson","year":"2009","journal-title":"Cereb Cortex"},{"issue":"5","key":"pone.0350611.ref062","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1002\/alz.13764","article-title":"Clinical validation of the PrecivityAD2 blood test: a mass spectrometry-based test with algorithm combining %p-tau217 and A\u03b242\/40 ratio to identify presence of brain amyloid","volume":"20","author":"MR Meyer","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"4","key":"pone.0350611.ref063","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/alz.12724","article-title":"Plasma A\u03b242\/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer\u2019s disease continuum: a cross-sectional and longitudinal study in the AIBL cohort","volume":"19","author":"P Chatterjee","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"4","key":"pone.0350611.ref064","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1177\/2211068215589580","article-title":"The Simoa HD-1 analyzer: a novel fully automated digital immunoassay analyzer with single-molecule sensitivity and multiplexing","volume":"21","author":"DH Wilson","year":"2016","journal-title":"J Lab Autom"},{"issue":"10","key":"pone.0350611.ref065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241641","article-title":"The Quick Physical Activity Rating (QPAR) scale: a brief assessment of physical activity in older adults with and without cognitive impairment","volume":"15","author":"JE Galvin","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"pone.0350611.ref066","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3233\/JAD-215077","article-title":"The Resilience Index: A Quantifiable Measure of Brain Health and Risk of Cognitive Impairment and Dementia","volume":"84","author":"JE Galvin","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"pone.0350611.ref067","first-page":"21","article-title":"Four factor index of social status","volume":"8","author":"AB Hollingshead","year":"2011","journal-title":"Yale J Sociol"},{"issue":"6","key":"pone.0350611.ref068","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"AS Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"pone.0350611.ref069","unstructured":"National Centers for Environmental Information. National centers for environmental information. Accessed 2026 April 14. https:\/\/www.ncei.noaa.gov\/"},{"key":"pone.0350611.ref070","article-title":"Testing the feasibility of tracking behavior and physiology patterns using wearable technology to detect potential cognitive risk among rural, multicultural older adults","volume":"19","author":"DJ Cook","year":"2023","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"3","key":"pone.0350611.ref071","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1080\/13854046.2024.2330143","article-title":"Predicting daily cognition and lifestyle behaviors for older adults using smart home data and ecological momentary assessment","volume":"40","author":"M Schmitter-Edgecombe","year":"2026","journal-title":"Clin Neuropsychol"},{"issue":"1","key":"pone.0350611.ref072","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3758\/s13428-010-0024-1","article-title":"A free, easy-to-use, computer-based simple and four-choice reaction time programme: the Deary-Liewald reaction time 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collection and assay protocol in the 2016 Health and Retirement Study: 2016 Venous Blood Study (VBS)","author":"EM Crimmins","year":"2017"},{"issue":"3","key":"pone.0350611.ref077","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1525-1497.2005.40198.x","article-title":"Differences in leisure-time, household, and work-related physical activity by race, ethnicity, and education","volume":"20","author":"XZ He","year":"2005","journal-title":"J Gen Intern Med"},{"issue":"3","key":"pone.0350611.ref078","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.amepre.2009.06.005","article-title":"Neighborhood safety, socioeconomic status, and physical activity in older adults","volume":"37","author":"RD Tucker-Seeley","year":"2009","journal-title":"Am J Prev Med"},{"issue":"1","key":"pone.0350611.ref079","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000255464","article-title":"Validation of the telephone interview for cognitive status-modified in subjects with normal cognition, mild cognitive impairment, or dementia","volume":"34","author":"DS Knopman","year":"2010","journal-title":"Neuroepidemiology"},{"key":"pone.0350611.ref080","volume-title":"Documentation of cognitive functioning measures in the Health and Retirement Study","author":"University of Michigan","year":"2005"},{"issue":"12","key":"pone.0350611.ref081","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.3390\/su16124955","article-title":"Cooling Benefits of Urban Tree Canopy: A Systematic Review","volume":"16","author":"Y Yin","year":"2024","journal-title":"Sustainability"},{"key":"pone.0350611.ref082","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.clinpsy.3.022806.091415","article-title":"Ecological momentary assessment","volume":"4","author":"S Shiffman","year":"2008","journal-title":"Annu Rev Clin Psychol"},{"key":"pone.0350611.ref083","doi-asserted-by":"crossref","DOI":"10.2196\/45028","article-title":"Ecological momentary assessment of cognition in clinical and community samples: reliability and validity study","volume":"25","author":"S Singh","year":"2023","journal-title":"J Med Internet Res"},{"issue":"23","key":"pone.0350611.ref084","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1001\/jama.2019.7437","article-title":"Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia","volume":"321","author":"Jr Jack CR","year":"2019","journal-title":"JAMA"},{"key":"pone.0350611.ref085","doi-asserted-by":"crossref","first-page":"128192","DOI":"10.1016\/j.ufug.2023.128192","article-title":"Urban tree canopies drive human heat stress mitigation","volume":"92","author":"L Gillerot","year":"2024","journal-title":"Urban Forestry & Urban Greening"},{"issue":"3","key":"pone.0350611.ref086","doi-asserted-by":"crossref","DOI":"10.1061\/JSWBAY.0000950","article-title":"Air temperature reductions at the base of tree canopies","volume":"7","author":"M Razzaghmanesh","year":"2021","journal-title":"J Sustain Water Built Environ"}],"container-title":["PLOS 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