{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:16:50Z","timestamp":1788787010587,"version":"build-2803163510"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cell and tissue engineering clinical research high-level talent cultivation innovation team","award":["04B24008B8"],"award-info":[{"award-number":["04B24008B8"]}]},{"name":"Guangxi Clinical Medical Research Center for Integrated Traditional Chinese and Western Medicine Kidney Diseases","award":["AD22035122"],"award-info":[{"award-number":["AD22035122"]}]},{"name":"Guangxi High-level Traditional Chinese Medicine Key Discipline Construction Pilot Project (Basic of Integrated Traditional Chinese and Western Medicine)"},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB24010077"],"award-info":[{"award-number":["AB24010077"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) complicates the course of critical illness and carries high short- and long-term mortality rates; however, reliable early prognostic markers remain limited. The leuko-glycemic index (LGI), the product of white blood cell counts and blood glucose, has shown prognostic value in other acute conditions; however, its role in intensive care unit (ICU) patients with AKI remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter retrospective cohort study, we analyzed 112,235 adult ICU admissions from the MIMIC-IV (n\u2009=\u200954,840) and eICU-CRD (n\u2009=\u200957,395) databases. Patients with multiple ICU stays and those aged &lt;18 years were excluded. The LGI was calculated within 24 h of admission and stratified into quartiles (Q1\u2013Q4). The primary endpoints were 30- and 90-day in-hospital mortality, and the secondary endpoint was overall in-hospital mortality. Kaplan\u2013Meier survival curves, multivariable Cox proportional hazards models, and restricted cubic splines (RCS) assess the association between LGI and outcomes, with subgroup and interaction analyses for key comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher LGI quartiles were associated with progressively worse survival (p\u2009&lt;\u20090.0001). In the fully adjusted models, each unit increase in LGI conferred a small but significant rise in 30-day (HR 1.01; 95% CI 1.01\u20131.01) and 90-day mortality (HR 1.01; 95% CI 1.01\u20131.01), while Q4 versus Q1 yielded HRs of 1.22 (95% CI 1.13\u20131.31) and 1.21 (95% CI 1.13\u20131.30), respectively. RCS demonstrated a nonlinear relationship, and the associations persisted across subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LGI may be an independent biomarker associated with short-term mortality in ICU patients with AKI. Its potential clinical relevance warrants further investigation and validation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0350811","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:22:51Z","timestamp":1780593771000},"page":"e0350811","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of leuko-glycemic index with mortality in ICU patients with Acute kidney injury: A retrospective multicenter cohort 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