{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:45:49Z","timestamp":1792691149598,"version":"4.5.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018978","name":"Zhejiang Office of Philosophy and Social Science","doi-asserted-by":"publisher","award":["23NDJC203YB"],"award-info":[{"award-number":["23NDJC203YB"]}],"id":[{"id":"10.13039\/100018978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012554","name":"Hubei Provincial Department of Education","doi-asserted-by":"publisher","award":["B2023210"],"award-info":[{"award-number":["B2023210"]}],"id":[{"id":"10.13039\/100012554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012554","name":"Hubei Provincial Department of Education","doi-asserted-by":"publisher","award":["24Y113"],"award-info":[{"award-number":["24Y113"]}],"id":[{"id":"10.13039\/100012554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to quantify domain-specific dose-response relationships between mind-body exercise and cognitive function in older adults with mild cognitive impairment (MCI), and to derive actionable dosing recommendation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight major electronic databases were systematically searched up to September 15, 2025. Randomized controlled trials (RCTs) of mind-body exercise intervention in individuals aged \u226560 years with MCI that reported at least one cognitive domain outcome were included. Hedges\u2019g effect sizes were calculated using random-effects models, and dose-response relationships were examined using restricted cubic spline regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-seven RCTs (2034 participants) were included. Moderate-certainty evidence supported improvements in global cognition (Hedges\u2019 g: 0.67, 95% CI: [0.49, 0.78]) and processing speed (0.45 [0.3, 0.6]). Global cognition exhibited a U-shaped weekly dose-response, with 240 min\/week as the relative nadir that still yielded a significant pooled effect (0.37; [0.19, 0.55]); longer intervention durations significantly amplified this overall response (\u03b2\u2009=\u20090.012, p\u2009&lt;\u20090.05), and achieving significant benefit at this dose required \u226511 weeks intervention. Memory followed a similar pattern, but with very low certainty. Processing speed showed a U-shaped cumulative dose-response (nadir: 3400 minutes), and this effect was attenuated by weekly dose (\u03b2\u2009=\u2009\u22120.0011, p\u2009&lt;\u20090.05), yet caution is warranted because the weekly doses in the included studies were heavily clustered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mind-body exercise produces domain-specific dose-response patterns in older adults with MCI. For global cognition, the observed U-shaped pattern suggests that if 240 min\/week dose is adopted clinically, extending intervention to at least 11 weeks is advisable. However, prospective validation of these findings is needed before clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0350867","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:51:37Z","timestamp":1790358697000},"page":"e0350867","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nonlinear dose-response of mind-body exercise in older adults with mild cognitive impairment: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-9373","authenticated-orcid":true,"given":"Yan-Fang","family":"Peng","sequence":"first","affiliation":[{"name":"Wuhan Sports University","place":["Wuhan, Hubei, China"],"department":["School of Physical Education"]},{"name":"Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"],"department":["School of Sport Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"],"department":["School of Rehabilitation Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Graduate School of Wuhan Sports University","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Cai","family":"Qu","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"],"department":["School of Sport Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"pone.0350867.ref001","unstructured":"Alzheimer\u2019s Disease International, Clare L, Jeon Y-H. 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