{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:02:48Z","timestamp":1780682568558,"version":"3.54.1"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Medical and Health Science and Technology Plan","award":["2023RC077"],"award-info":[{"award-number":["2023RC077"]}]},{"name":"Major Science and Technology Plan Project of Xiaoshan District","award":["2022210"],"award-info":[{"award-number":["2022210"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic cardiomyopathy (DCM) is a diabetes-related myocardial disorder causing fibrosis, hypertrophy, and progressive diastolic and systolic dysfunction. This study aims to explore how metabolic, inflammatory, and fibrotic mechanisms in non-cardiomyocytes drive DCM to reveal new therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-cell RNA sequencing (scRNA-seq) was performed to investigate the role of non-cardiomyocytes in DCM, enabling the identification of cell types, gene expression dynamics, and intercellular communication networks in patients with type 2 diabetes. The scRNA-seq data were obtained from the GEO to investigate cell-type-specific contributions and heterogeneity across tissues. Metabolic pathway scores were calculated using scMetabolism. Moreover, cell trajectory analysis and cellular communication studies were performed to examine shared and disease-specific cell populations in diabetes and cardiomyopathy. CCK-8, colony formation, Transwell migration and invasion assays were preformed to explore the function of PTPRC in HUVECs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using SingleR annotation, we identified eight distinct cell types, with NK cells and smooth muscle cells representing the shared cell populations across both diseases. Cell trajectory analysis revealed three distinct branches based on gene expression over pseudotime, and the top differentially expressed genes in each cell type clustering into six categories. Metabolic pathway analysis predicted that epithelial cells, macrophages, and neurons as the most metabolically active across multiple pathways, highlighting metabolic heterogeneity among patient samples. Additionally, four key signaling pathways associated with NK cells and smooth muscle cells were predicted to emphasize the divergence in gene expression across cell types. PTPRC is implicated in diabetes and cardiomyopathy and functions as a positive regulator of HUVEC viability, clonogenic growth, migration, and invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates significant heterogeneity among non-cardiomyocytes in patients with diabetes and cardiomyopathy, highlighting the need for targeted therapeutic interventions to address these differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0351057","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:26:59Z","timestamp":1780680419000},"page":"e0351057","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of non-cardiomyocytes marker genes in patients with diabetes and cardiomyopathy through single-cell analysis"],"prefix":"10.1371","volume":"21","author":[{"given":"Wenze","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanglie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1926-8282","authenticated-orcid":true,"given":"Haihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"pone.0351057.ref001","doi-asserted-by":"crossref","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"H Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"issue":"18","key":"pone.0351057.ref002","article-title":"Emerging targets in type 2 diabetes and diabetic complications","volume":"8","author":"S Demir","year":"2021","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"pone.0351057.ref003","article-title":"Type 1 diabetes mellitus","volume":"175","author":"FZ Syed","year":"2022","journal-title":"Ann Intern Med"},{"issue":"1","key":"pone.0351057.ref004","first-page":"28","article-title":"The national and provincial prevalence and non-fatal burdens of diabetes in China from 2005 to 2023 with projections of prevalence to 2050","volume":"12","author":"Y-C Zhou","year":"2025","journal-title":"Mil Med Res"},{"issue":"8","key":"pone.0351057.ref005","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.118.314665","article-title":"Diabetic cardiomyopathy","volume":"124","author":"WH Dillmann","year":"2019","journal-title":"Circulation Research"},{"issue":"4","key":"pone.0351057.ref006","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/heartjnl-2016-310342","article-title":"Diabetic cardiomyopathy","volume":"105","author":"MMY Lee","year":"2019","journal-title":"Heart"},{"issue":"4","key":"pone.0351057.ref007","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pcad.2019.03.003","article-title":"Diabetic cardiomyopathy - a comprehensive updated review","volume":"62","author":"G Murtaza","year":"2019","journal-title":"Prog Cardiovasc Dis"},{"issue":"11","key":"pone.0351057.ref008","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.120.315913","article-title":"Basic mechanisms of diabetic heart disease","volume":"126","author":"RH Ritchie","year":"2020","journal-title":"Circulation Research"},{"key":"pone.0351057.ref009","doi-asserted-by":"crossref","first-page":"155313","DOI":"10.1016\/j.metabol.2022.155313","article-title":"Mitochondrial quality control mechanisms as molecular targets in diabetic heart","volume":"137","author":"X Chang","year":"2022","journal-title":"Metabolism"},{"issue":"3","key":"pone.0351057.ref010","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/cvr\/cvw159","article-title":"Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy","volume":"111","author":"A Wan","year":"2016","journal-title":"Cardiovascular Research"},{"issue":"5","key":"pone.0351057.ref011","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jcmg.2020.05.036","article-title":"Imaging interstitial fibrosis, left ventricular remodeling, and function in stage A and B heart failure","volume":"14","author":"T Pezel","year":"2021","journal-title":"JACC Cardiovascular Imaging"},{"key":"pone.0351057.ref012","doi-asserted-by":"crossref","first-page":"907757","DOI":"10.3389\/fendo.2022.907757","article-title":"Signaling pathways related to oxidative stress in diabetic cardiomyopathy","volume":"13","author":"M-L Peng","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"pone.0351057.ref013","doi-asserted-by":"crossref","first-page":"5913374","DOI":"10.1155\/2022\/5913374","article-title":"Oxidative stress signaling mediated pathogenesis of diabetic cardiomyopathy","volume":"2022","author":"Z Tang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"pone.0351057.ref014","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/heartjnl-2017-311448","article-title":"Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting","volume":"104","author":"AJ Wilson","year":"2018","journal-title":"Heart"},{"issue":"1","key":"pone.0351057.ref015","first-page":"11","article-title":"Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways","volume":"11","author":"ML Cummins","year":"2024","journal-title":"Mil Med Res"},{"issue":"1","key":"pone.0351057.ref016","first-page":"1","article-title":"Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy","volume":"11","author":"SS Jankauskas","year":"2024","journal-title":"Mil Med Res"},{"issue":"1","key":"pone.0351057.ref017","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41392-024-01840-1","article-title":"Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets","volume":"9","author":"R Chen","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"pone.0351057.ref018","doi-asserted-by":"crossref","first-page":"156083","DOI":"10.1016\/j.metabol.2024.156083","article-title":"The role of IL-1 family cytokines in diabetic cardiomyopathy","volume":"163","author":"Q Wu","year":"2025","journal-title":"Metabolism"},{"issue":"1","key":"pone.0351057.ref019","first-page":"26","article-title":"GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis","volume":"12","author":"K-J Chen","year":"2025","journal-title":"Mil Med Res"},{"issue":"1","key":"pone.0351057.ref020","first-page":"33","article-title":"Advancing skeletal health and disease research with single-cell RNA sequencing","volume":"11","author":"P Lin","year":"2024","journal-title":"Mil Med Res"},{"issue":"1","key":"pone.0351057.ref021","first-page":"21","article-title":"The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy","volume":"11","author":"D-C Feng","year":"2024","journal-title":"Mil Med Res"},{"key":"pone.0351057.ref022","article-title":"Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy","volume":"12","author":"W Li","year":"2023","journal-title":"Elife"},{"key":"pone.0351057.ref023","doi-asserted-by":"crossref","first-page":"111858","DOI":"10.1016\/j.intimp.2024.111858","article-title":"Interleukin-1\u03b2 polarization in M1 macrophage mediates myocardial fibrosis in diabetes","volume":"131","author":"W Guo","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"pone.0351057.ref024","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jare.2022.02.017","article-title":"SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis","volume":"43","author":"CK Cheng","year":"2023","journal-title":"J Adv Res"},{"key":"pone.0351057.ref025","doi-asserted-by":"crossref","first-page":"689469","DOI":"10.3389\/fcell.2021.689469","article-title":"Single-cell transcriptomics reveals endothelial plasticity during diabetic atherogenesis","volume":"9","author":"G Zhao","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"3","key":"pone.0351057.ref026","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302003R","article-title":"Multi-organ single-cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulation","volume":"38","author":"AT Braithwaite","year":"2024","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"7838","key":"pone.0351057.ref027","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"M Litvi\u0148ukov\u00e1","year":"2020","journal-title":"Nature"},{"issue":"3","key":"pone.0351057.ref028","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/cvr\/cvac049","article-title":"Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy","volume":"119","author":"RJ Phang","year":"2023","journal-title":"Cardiovasc Res"},{"key":"pone.0351057.ref029","doi-asserted-by":"crossref","first-page":"3790721","DOI":"10.1155\/2022\/3790721","article-title":"The role of NLRP3 inflammasome in diabetic cardiomyopathy and its therapeutic implications","volume":"2022","author":"K Ding","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"pone.0351057.ref030","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1186\/s12964-024-01842-0","article-title":"The role of nonmyocardial cells in the development of diabetic cardiomyopathy and the protective effects of FGF21: a current understanding","volume":"22","author":"T Zhang","year":"2024","journal-title":"Cell Commun Signal"},{"issue":"12","key":"pone.0351057.ref031","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41569-021-00569-6","article-title":"PPAR control of metabolism and cardiovascular functions","volume":"18","author":"D Montaigne","year":"2021","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"pone.0351057.ref032","first-page":"49","article-title":"Hippocampal PACAP signaling activation triggers a rapid antidepressant response","volume":"11","author":"H-L Zhang","year":"2024","journal-title":"Mil Med Res"},{"issue":"1","key":"pone.0351057.ref033","first-page":"36","article-title":"Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis","volume":"12","author":"Y-J Xu","year":"2025","journal-title":"Mil Med Res"},{"key":"pone.0351057.ref034","article-title":"Negative coronary artery remodeling in young properly controlled diabetic patients is associated with diabetes duration","volume":"44","author":"AAM Farrag","year":"2023","journal-title":"European Heart Journal"},{"key":"pone.0351057.ref035","doi-asserted-by":"crossref","first-page":"2042018819834869","DOI":"10.1177\/2042018819834869","article-title":"Diabetic cardiomyopathy: prevalence, determinants and potential treatments","volume":"10","author":"GS Gulsin","year":"2019","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"8","key":"pone.0351057.ref036","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.3390\/ijms21082896","article-title":"Diabetic cardiomyopathy and ischemic heart disease: prevention and therapy by exercise and conditioning","volume":"21","author":"A Crisafulli","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"7","key":"pone.0351057.ref037","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3390\/nu14071322","article-title":"Ketogenic diet and cardiac substrate metabolism","volume":"14","author":"TV Luong","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"pone.0351057.ref038","doi-asserted-by":"crossref","DOI":"10.3390\/nu13072476","article-title":"Effects of bergamot polyphenols on mitochondrial dysfunction and sarcoplasmic reticulum stress in diabetic cardiomyopathy","volume":"13","author":"J Maiuolo","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"pone.0351057.ref039","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12916-022-02483-1","article-title":"Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy: a Mendelian randomization study","volume":"20","author":"M Ardissino","year":"2022","journal-title":"BMC Med"},{"issue":"18","key":"pone.0351057.ref040","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"145","author":"PA Heidenreich","year":"2022","journal-title":"Circulation"},{"issue":"1","key":"pone.0351057.ref041","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12933-022-01573-x","article-title":"Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts","volume":"21","author":"R Marfella","year":"2022","journal-title":"Cardiovasc Diabetol"},{"issue":"8","key":"pone.0351057.ref042","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1042\/CS20120448","article-title":"Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor","volume":"124","author":"CM Thomas","year":"2013","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"pone.0351057.ref043","article-title":"The adaptive immune role of metallothioneins in the pathogenesis of diabetic cardiomyopathy: good or bad","volume":"317","author":"T Ge","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"24","key":"pone.0351057.ref044","doi-asserted-by":"crossref","first-page":"13228","DOI":"10.3390\/ijms222413228","article-title":"NLRP3 inflammasome in diabetic cardiomyopathy and exercise intervention","volume":"22","author":"Y Sun","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"561","key":"pone.0351057.ref045","article-title":"ORAI1, STIM1\/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation","volume":"11","author":"B-P Diercks","year":"2018","journal-title":"Sci Signal"},{"key":"pone.0351057.ref046","doi-asserted-by":"crossref","first-page":"2164017","DOI":"10.1155\/2019\/2164017","article-title":"Role of inflammatory cell subtypes in heart failure","volume":"2019","author":"D Strassheim","year":"2019","journal-title":"J Immunol Res"},{"issue":"3","key":"pone.0351057.ref047","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41577-018-0110-7","article-title":"Calcium signalling in T cells","volume":"19","author":"M Trebak","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"pone.0351057.ref048","doi-asserted-by":"crossref","first-page":"1393392","DOI":"10.3389\/fimmu.2024.1393392","article-title":"The role and therapeutic potential of macrophages in the pathogenesis of diabetic cardiomyopathy","volume":"15","author":"S Zhang","year":"2024","journal-title":"Front Immunol"},{"issue":"1","key":"pone.0351057.ref049","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12933-024-02178-2","article-title":"MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus","volume":"23","author":"XM Ma","year":"2024","journal-title":"Cardiovasc Diabetol"},{"issue":"12","key":"pone.0351057.ref050","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1038\/s44319-024-00271-x","article-title":"Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy","volume":"25","author":"J Li","year":"2024","journal-title":"EMBO Rep"},{"issue":"2","key":"pone.0351057.ref051","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1124\/jpet.123.002037","article-title":"Cannabinoid 2 receptor activation protects against diabetic cardiomyopathy through inhibition of AGE\/RAGE-induced oxidative stress, fibrosis, and inflammasome activation","volume":"391","author":"HM Hashiesh","year":"2024","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"pone.0351057.ref052","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13287-024-03715-2","article-title":"Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy","volume":"15","author":"B Liu","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"pone.0351057.ref053","doi-asserted-by":"crossref","first-page":"1478139","DOI":"10.3389\/fendo.2025.1478139","article-title":"Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning","volume":"16","author":"Q Tang","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"pone.0351057.ref054","first-page":"122","article-title":"MicroRNA 21 emerging role in diabetic complications: a critical update","volume":"17","author":"D Roy","year":"2021","journal-title":"Curr Diabetes Rev"},{"issue":"1","key":"pone.0351057.ref055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12967-024-05983-1","article-title":"Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy","volume":"23","author":"S He","year":"2025","journal-title":"J Transl Med"},{"issue":"10","key":"pone.0351057.ref056","doi-asserted-by":"crossref","first-page":"107759","DOI":"10.1016\/j.isci.2023.107759","article-title":"Mapping the cellular and molecular landscape of cardiac non-myocytes in murine diabetic cardiomyopathy","volume":"26","author":"CD Cohen","year":"2023","journal-title":"iScience"},{"issue":"9","key":"pone.0351057.ref057","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/jclinpath-2020-206927","article-title":"Protein tyrosine phosphatase receptor type C (PTPRC or CD45)","volume":"74","author":"MA Al Barashdi","year":"2021","journal-title":"J Clin Pathol"},{"key":"pone.0351057.ref058","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijcard.2019.12.002","article-title":"RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy","volume":"302","author":"CL Hall","year":"2020","journal-title":"Int J Cardiol"},{"issue":"5","key":"pone.0351057.ref059","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1007\/s10528-024-10937-9","article-title":"Identification and verification of potential markers related to myocardial fibrosis by bioinformatics analysis","volume":"63","author":"J Huang","year":"2025","journal-title":"Biochem Genet"},{"key":"pone.0351057.ref060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.semcancer.2024.05.001","article-title":"p53\/MDM2 signaling pathway in aging, senescence and tumorigenesis","volume":"101","author":"Y Huang","year":"2024","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"pone.0351057.ref061","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1186\/s12967-024-05623-8","article-title":"The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53\/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes","volume":"22","author":"J Borlak","year":"2024","journal-title":"J Transl Med"},{"issue":"5","key":"pone.0351057.ref062","first-page":"1641","article-title":"Identifying critical genes and pathways of doxorubicin-induced cardiomyopathy via bioinformatics analysis","volume":"28","author":"G Fan","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"pone.0351057.ref063","first-page":"3282656","article-title":"Galectin-3 knockdown impairs survival, migration, and immunomodulatory actions of mesenchymal stromal cells in a mouse model of Chagas disease cardiomyopathy","volume":"2017","author":"BSF Souza","year":"2017","journal-title":"Stem Cells Int"},{"key":"pone.0351057.ref064","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.2147\/DMSO.S526696","article-title":"Multi-omics analysis and nephroseq database of genes related to kidney function in diabetic nephropathy patients to predict potential target drugs","volume":"18","author":"L Deng","year":"2025","journal-title":"Diabetes Metab Syndr Obes"},{"key":"pone.0351057.ref065","doi-asserted-by":"crossref","first-page":"839865","DOI":"10.3389\/fendo.2022.839865","article-title":"Identification of inflammation-related biomarkers in diabetes of the exocrine pancreas with the use of weighted gene co-expression network analysis","volume":"13","author":"G Li","year":"2022","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0351057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:27:13Z","timestamp":1780680433000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0351057"}},"subtitle":[],"editor":[{"given":"Doa\u2019a G. F.","family":"Al-u\u2019datt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":65,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0351057","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}