{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:16:32Z","timestamp":1783707392006,"version":"3.55.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General project of Guangdong Provincial Basic and Applied Basic Research Foundation","award":["2021A1515011353"],"award-info":[{"award-number":["2021A1515011353"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030310297"],"award-info":[{"award-number":["2018A030310297"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of Guangzhou National Laboratory","award":["GZNL2023A03009"],"award-info":[{"award-number":["GZNL2023A03009"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optical coherence elastography derived from optical coherence tomography for measuring soft tissue and organ compliance, holds promise in respirology but remains largely exploratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The airway lumen area (Ai) was measured by endobronchial optical coherence tomography in control subjects (n\u2009=\u20094), and pulmonary fibrosis (n\u2009=\u20098) while airway pressure (Paw) increased from 0\u201320\u2009cm H\n                      <jats:sub>2<\/jats:sub>\n                      O. Airway compliance (AC) and airway specific compliance (ASC) were derived from the Paw vs. Ai curves. Evaluate correlations among Ai, AC, ASC, and lung function parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Endobronchial optical coherence elastography (EB-OCE) was constructed by ASC, which could detect AC and ASC among 3\n                      <jats:sup>rd<\/jats:sup>\n                      to 7\n                      <jats:sup>th<\/jats:sup>\n                      generations of bronchi. Pulmonary fibrosis tended to exhibit lower ASC in 5\n                      <jats:sup>th<\/jats:sup>\n                      to 7\n                      <jats:sup>th<\/jats:sup>\n                      generations of bronchi compared to controls. The ASC-7 appeared to be positively correlated with FEV\u2081, FVC, TLC, VC, and DLCO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EB-OCE provides a novel approach to measure AC and extends the analysis to small airway. Pulmonary fibrosis appeared to show a heterogeneous reduction in AC across different bronchial generations compared to controls. 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