{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:33:28Z","timestamp":1782934408317,"version":"3.54.5"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China Precision Medicine Initiative","award":["2016YFC0906300"],"award-info":[{"award-number":["2016YFC0906300"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This study evaluated\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      GUANKE\u2019s protective effects on ZEN-induced intestinal dysfunction and explored its molecular mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In vitro, IPEC-J2 cells were divided into control, ZEN (40 \u03bcM), GUANKE (20 MOI), and ZEN+GUANKE groups (24 h treatment). Cell viability (CCK-8), oxidative stress indicators (LDH, ROS, T-SOD, GSH, MDA), and inflammatory cytokine mRNAs (\n                      <jats:italic>IL-1\u03b2, IL-6, TNF-\u03b1, IL-10<\/jats:italic>\n                      ) were detected. In vivo, Balb\/c mice were randomized into five groups (control, ZEN, GUANKE, ZEN\u2009+\u2009LG, ZEN\u2009+\u2009HG) for 28 days of intervention. Jejunum histology (H&amp;E staining), oxidative stress\/inflammatory factors (kits\/ELISA), serum intestinal function indices (D-xylose, D-lactate, DAO), and transcriptomic analysis were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      GUANKE significantly improved IPEC-J2 cell viability, reduced LDH release (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and ROS accumulation\n                      <jats:italic>(P<\/jats:italic>\n                      \u2009&lt;\u20090.001), restored T-SOD\/GSH activities\n                      <jats:italic>(P<\/jats:italic>\n                      \u2009&lt;\u20090.05), decreased MDA (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), suppressed pro-inflammatory cytokines\n                      <jats:italic>(IL-1\u03b2, IL-6, TNF-\u03b1<\/jats:italic>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and upregulated\n                      <jats:italic>IL-10<\/jats:italic>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). In mice\n                      <jats:italic>, L. plantarum<\/jats:italic>\n                      GUANKE increased villus height\/crypt depth ratio (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), restored antioxidant status (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and rebalanced cytokine expression (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 for pro-inflammatory;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01 for IL-10). Transcriptomic analysis suggested that ZEN activated the NF-\u03baB pathway, while\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      GUANKE treatment was associated with reduced pathway activity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0351300","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:45:16Z","timestamp":1782927916000},"page":"e0351300","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactiplantibacillus plantarum GUANKE alleviates Zearalenone-induced intestinal dysfunction by modulating oxidative stress and inflammation"],"prefix":"10.1371","volume":"21","author":[{"given":"Qiaoning","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bugao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-9472","authenticated-orcid":true,"given":"Ming 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