{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:58:47Z","timestamp":1781632727311,"version":"3.54.5"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer survivors frequently experience depression and metabolic dysfunction; however, the combined impact of these conditions remains understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to examine the joint associations between cancer, metabolic syndrome, and depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the 2007\u20132021 Korea National Health and Nutrition Examination Survey encompassed 57,176 participants aged\u2009\u2265\u200919 years. Cancer diagnosis and components of metabolic syndrome (waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, and fasting glucose) were obtained through self-report or clinical measurement. Depression was assessed using a single-item question regarding persistent sadness or hopelessness. Multivariable logistic regression models evaluated the associations among cancer, metabolic syndrome, and depression, adjusting for sociodemographic and lifestyle factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among participants, 1,691 (3.0%) had cancer, 17,510 (30.7%) met criteria for metabolic syndrome, and 7,472 (13.1%) reported depression. Cancer was independently associated with increased risk of depression (odds ratio: 1.26; 95% confidence interval: 1.10\u20131.45). While metabolic syndrome alone was not significantly associated with depression, patients with cancer who had elevated triglycerides (\u2265 150\u2009mg\/dL) or decreased high-density lipoprotein cholesterol exhibited substantially higher risk of depression (odds ratio: 1.51; 95% confidence interval: 1.17\u20131.95 and odds ratio: 1.32; 95% confidence interval: 1.07\u20131.62, respectively). The association between elevated triglycerides in cancer survivors and depression remained robust after FDR correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Specific lipid abnormalities, rather than metabolic syndrome as a whole, were significantly associated with a higher prevalence of depression among cancer survivors. These findings underscore the need for integrated screening and management that address both metabolic dysfunction and mental health in cancer survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0351399","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:31:26Z","timestamp":1781631086000},"page":"e0351399","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined effect of metabolic syndrome and cancer on 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