{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:51:38Z","timestamp":1782237098345,"version":"3.54.5"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15GM11750"],"award-info":[{"award-number":["R15GM11750"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15DK127440"],"award-info":[{"award-number":["R15DK127440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Psoriasis is a chronic skin disease that results in scaly patches and affects 2\u20133% of people worldwide. Therapeutic treatment targets the TNF-\u03b1\/IL-17 axis to disrupt keratinocyte hyperproliferation and inflammation. While more is known about the role of dermal \u03b1\u00df and \u03b3\u03b4 T cells in IL-17 production, less is understood about the role of resident epidermal T cells. Here, we examine how TNF-\u03b1 modulates epidermal \u03b3\u03b4 T cell activation and function. We show that a subset of activated epidermal \u03b3\u03b4 T cells expresses TNFR2 with or without TNFR1. Stimulation with TNF-\u03b1 induces epidermal \u03b3\u03b4 T cells to produce IL-17 family cytokines and chemokines. Epidermal \u03b3\u03b4 T cells do not require TNFR1 or 2 for development or homing to the skin. Instead, TNFR2 plays roles in epidermal \u03b3\u03b4 T cell function skewing them toward a T\u03b3\u03b417 phenotype during psoriasis. Investigation of the mechanisms by which TNF-\u03b1 associated inflammation impacts epidermal \u03b3\u03b4 T cell function may help identify new cellular targets for immunotherapy or mark them as early regulators of skin inflammation.<\/jats:p>","DOI":"10.1371\/journal.pone.0351508","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:32:29Z","timestamp":1782235949000},"page":"e0351508","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["TNFR2 is expressed by a discrete subset of epidermal T cells with an IL-17 gene signature during psoriasis"],"prefix":"10.1371","volume":"21","author":[{"given":"Jasmine","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Tulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela","family":"Rhoiney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-4066","authenticated-orcid":true,"given":"Julie 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