{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:50:32Z","timestamp":1782237032490,"version":"3.54.5"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>This study investigated the relationship between Corvis ST tonometry parameters and mean blur rate in the optic nerve head tissue area (MBR-T) in healthy eyes. Corneal biomechanical properties and MBR-T were measured in 100 eyes from 56 healthy participants in Japan using Corvis ST tonometry and laser speckle flowgraphy, respectively. Axial length, central corneal thickness, and intraocular pressure were also recorded. Linear mixed-effects models were applied to evaluate the associations between corneal biomechanical properties and MBR-T. Model selection was performed using the second-order bias-corrected Akaike Information Criterion (AICc). The optimal predictive model for MBR-T was as follows: MBR-T\u2009=\u200921.1607 (intercept) \u2013 1.6317\u2009\u00d7\u2009Sex (Male) \u2013 4.8626\u2009\u00d7\u2009A2 deformation amplitude \u2013 5.7932\u2009\u00d7\u2009HC deformation amplitude (AICc\u2009=\u2009409.9). In healthy eyes, greater corneal deformability was associated with lower MBR-T.<\/jats:p>","DOI":"10.1371\/journal.pone.0351637","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:23:56Z","timestamp":1782235436000},"page":"e0351637","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between Corvis ST tonometry parameters and mean blur rate in the optic nerve head tissue area in healthy eyes"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-1017","authenticated-orcid":true,"given":"Yuta","family":"Nakaniida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Higashikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Tokumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Nakakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Asaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-9242","authenticated-orcid":true,"given":"Hirokazu","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"pone.0351637.ref001","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1475-925X-13-150","article-title":"Automatic method of analysis and measurement of additional parameters of corneal deformation in the Corvis tonometer","volume":"13","author":"R Koprowski","year":"2014","journal-title":"Biomed Eng Online"},{"issue":"4","key":"pone.0351637.ref002","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.61.4.19","article-title":"Dynamic scheimpflug ocular biomechanical parameters in untreated primary open angle glaucoma eyes","volume":"61","author":"A Miki","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"pone.0351637.ref003","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1755-3768.2009.01586.x","article-title":"Use of laser speckle flowgraphy in ocular blood flow research","volume":"88","author":"T Sugiyama","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"pone.0351637.ref004","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.2147\/OPTH.S213031","article-title":"Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes","volume":"13","author":"R Kohmoto","year":"2019","journal-title":"Clin Ophthalmol"},{"issue":"11","key":"pone.0351637.ref005","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3109\/02713683.2015.1127974","article-title":"Optic nerve head blood flow, as measured by laser speckle flowgraphy, is significantly reduced in preperimetric glaucoma","volume":"41","author":"Y Shiga","year":"2016","journal-title":"Curr Eye Res"},{"issue":"13","key":"pone.0351637.ref006","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1167\/iovs.19-27087","article-title":"Association of corneal hysteresis with lamina cribrosa curvature in primary open angle glaucoma","volume":"60","author":"KM Lee","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"pone.0351637.ref007","doi-asserted-by":"crossref","first-page":"24","DOI":"10.18502\/jovr.v15i1.5936","article-title":"Corneal parameters in healthy subjects assessed by corvis ST","volume":"15","author":"R Salouti","year":"2020","journal-title":"J Ophthalmic Vis Res"},{"issue":"17","key":"pone.0351637.ref008","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.3390\/jcm10173860","article-title":"How to measure intraocular pressure: an updated review of various tonometers","volume":"10","author":"P Brusini","year":"2021","journal-title":"J Clin Med"},{"issue":"2","key":"pone.0351637.ref009","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/archopht.1974.03900060140012","article-title":"A noncontact applanation tonometer. 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