{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:54:44Z","timestamp":1791309284622,"version":"4.3.1"},"reference-count":131,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE027073"],"award-info":[{"award-number":["R01DE027073"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["F31DE033627"],"award-info":[{"award-number":["F31DE033627"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R25GM095459"],"award-info":[{"award-number":["R25GM095459"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM144920"],"award-info":[{"award-number":["T32GM144920"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007930","name":"Institute of Clinical and Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001412"],"award-info":[{"award-number":["UL1TR001412"]}],"id":[{"id":"10.13039\/100007930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG083727"],"award-info":[{"award-number":["AG083727"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Periodontitis (PD) is a common chronic inflammatory condition and a risk factor for cardiovascular diseases (CVD), yet underlying linking mechanisms remain unclear. The cytokine Oncostatin M(OSM) is elevated in both PD and CVD and has emerged as a potential mediator linking oral inflammation to vascular dysfunction. Neutrophils represent a prominent source of OSM during PD and OSM production is elevated by the periodontal pathobiont\n                    <jats:italic>Treponema denticola<\/jats:italic>\n                    (Td). This study investigated the role of exogenous and neutrophil-derived OSM in endothelial cell (EC) dysfunction and the contribution of heterogenous oral\n                    <jats:italic>Treponema<\/jats:italic>\n                    species in OSM production. Human aortic endothelial cells (HAoEC) were used to evaluate the effects of exogenous purified OSM and neutrophil-derived OSM on endothelial cell function. Endothelial permeability, neutrophil transmigration, cytokine production, cell activation and junctional integrity were assessed using transwell assays,\u00a0ELISA, real-time PCR, immunoblotting and immunofluorescence microscopy. Exogenous OSM significantly increased HAoEC permeability, neutrophil transmigration and promoted endothelial activation; characterized by increased E-selectin, ICAM-1 and IL-6 expression. Mechanistically, OSM activated OSMR-STAT3 signaling and altered organization of VE-cadherin in adherens junctions and decreased expression of occludin in tight-junctions. Heterogeneous oral\n                    <jats:italic>Treponema<\/jats:italic>\n                    species promote OSM transcription and production from mouse and human neutrophils in vitro and in vivo using a mouse air pouch model of infection.\n                    <jats:italic>T. denticola<\/jats:italic>\n                    most robustly induced OSM release, likely independent of prominent virulence factors dentilisin and Msp. Co-culture model experiments revealed conditioned media from\n                    <jats:italic>T. denticola<\/jats:italic>\n                    -stimulated neutrophils promoted endothelial cell permeability and IL-6 while reducing endothelial nitric oxide synthase (eNOS) production. These effects were abolished by antibody neutralization of OSM, supporting a casual role of neutrophil-derived OSM. Overall, these findings provide mechanistic insight into putative links between PD and adverse cardiovascular events and identify OSM signaling as critical mediator in inflammation-driven endothelial dysfunction.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0351640","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:38:57Z","timestamp":1791308337000},"page":"e0351640","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil-derived oncostatin m contributes to endothelial cell dysfunction during Treponema denticola interaction"],"prefix":"10.1371","volume":"21","author":[{"given":"Dayron M.","family":"Leyva Rodriguez","sequence":"first","affiliation":[{"name":"The State University of New York at Buffalo","place":["Buffalo, New York, United States of America"],"department":["Department of Oral Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-3314","authenticated-orcid":true,"given":"Michelle B.","family":"Visser","sequence":"additional","affiliation":[{"name":"The State University of New York at Buffalo","place":["Buffalo, New York, United States of America"],"department":["Department of Oral Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"2","key":"pone.0351640.ref001","article-title":"Periodontitis is associated to increased systemic inflammation in postmyocardial infarction patients","volume":"8","author":"PAROKRANK Steering Committee","year":"2021","journal-title":"Open Heart"},{"issue":"4","key":"pone.0351640.ref002","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4248\/IJOS10077","article-title":"Correlation of levels of oncostatin M cytokine in crevicular fluid and serum in periodontal disease","volume":"2","author":"M Thorat","year":"2010","journal-title":"Int J Oral Sci"},{"issue":"2","key":"pone.0351640.ref003","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/0972-124X.55840","article-title":"Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis","volume":"13","author":"DK Gani","year":"2009","journal-title":"J Indian Soc Periodontol"},{"issue":"1","key":"pone.0351640.ref004","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/00325481.2018.1396876","article-title":"Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases","volume":"130","author":"EM Cardoso","year":"2018","journal-title":"Postgrad Med"},{"issue":"10","key":"pone.0351640.ref005","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1902\/jop.2000.71.10.1528","article-title":"Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of 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Grenier","year":"1999","journal-title":"Blood"},{"key":"pone.0351640.ref034","doi-asserted-by":"crossref","first-page":"1568983","DOI":"10.3389\/froh.2025.1568983","article-title":"Emerging oral Treponema membrane proteins disorder neutrophil phosphoinositide signaling via phosphatidylinositol-4-phosphate 5-kinase","volume":"6","author":"NK Anselmi","year":"2025","journal-title":"Front Oral Health"},{"issue":"1","key":"pone.0351640.ref035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41522-020-0120-7","article-title":"Polymicrobial periodontal disease triggers a wide radius of effect and unique virome","volume":"6","author":"L Gao","year":"2020","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"pone.0351640.ref036","article-title":"Oncostatin M and Cardiovascular Diseases: A Narrative Review","volume":"1","author":"L Askin","year":"2025","journal-title":"Interv Cardiol Perspect"},{"issue":"3","key":"pone.0351640.ref037","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3390\/ijms23031448","article-title":"Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells","volume":"23","author":"M Lindkvist","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"2","key":"pone.0351640.ref038","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.atherosclerosis.2011.02.003","article-title":"Oncostatin M is expressed in atherosclerotic lesions: a role for Oncostatin M in the pathogenesis of atherosclerosis","volume":"216","author":"A Albasanz-Puig","year":"2011","journal-title":"Atherosclerosis"},{"key":"pone.0351640.ref039","doi-asserted-by":"crossref","first-page":"155972","DOI":"10.1016\/j.cyto.2022.155972","article-title":"Exogenous oncostatin M induces cardiac dysfunction, musculoskeletal atrophy, and fibrosis","volume":"159","author":"DHA Jengelley","year":"2022","journal-title":"Cytokine"},{"issue":"8","key":"pone.0351640.ref040","doi-asserted-by":"crossref","first-page":"456","DOI":"10.21037\/atm-22-560","article-title":"Oncostatin M promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the NF-\u03baB pathway in THP-1 macrophages and promotes the progression of atherosclerosis","volume":"10","author":"C Liu","year":"2022","journal-title":"Ann Transl Med"},{"issue":"6","key":"pone.0351640.ref041","doi-asserted-by":"crossref","first-page":"223","DOI":"10.31083\/j.fbl2906223","article-title":"Endothelial Cell Dysfunction: Onset, Progression, and Consequences","volume":"29","author":"H Naderi-Meshkin","year":"2024","journal-title":"Front Biosci (Landmark Ed)"},{"key":"pone.0351640.ref042","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fphys.2015.00365","article-title":"Endothelial Barrier and Its Abnormalities in Cardiovascular Disease","volume":"6","author":"DA Chistiakov","year":"2015","journal-title":"Front Physiol"},{"issue":"4","key":"pone.0351640.ref043","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5830\/CVJA-2011-068","article-title":"Endothelial dysfunction: the early predictor of atherosclerosis","volume":"23","author":"M Mudau","year":"2012","journal-title":"Cardiovasc J Afr"},{"issue":"10","key":"pone.0351640.ref044","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204911","article-title":"Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice","volume":"13","author":"D van Keulen","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"pone.0351640.ref045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1182\/bloodadvances.2018026294","article-title":"Endothelial signaling by neutrophil-released oncostatin M enhances P-selectin-dependent inflammation and thrombosis","volume":"3","author":"H Setiadi","year":"2019","journal-title":"Blood Adv"},{"issue":"2","key":"pone.0351640.ref046","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pcad.2007.04.001","article-title":"Large and small vessels atherosclerosis: similarities and differences","volume":"50","author":"V Aboyans","year":"2007","journal-title":"Prog Cardiovasc Dis"},{"issue":"4","key":"pone.0351640.ref047","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1538\/expanim.47.221","article-title":"Macroscopic distribution of coronary atherosclerotic lesions in cholesterol-fed rabbits","volume":"47","author":"S Kitajima","year":"1998","journal-title":"Exp Anim"},{"key":"pone.0351640.ref048","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"E Falk","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"pone.0351640.ref049","article-title":"Laboratory maintenance of Treponema denticola","volume-title":"Curr 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Rep"},{"key":"pone.0351640.ref053","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejogrb.2016.03.044","article-title":"Effects of drospirenone on adhesion molecule expression and monocyte adherence in human endothelial cells","volume":"201","author":"F Ito","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"7","key":"pone.0351640.ref054","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/jcpe.13293","article-title":"Leucocyte- and platelet-rich fibrin regulates expression of genes related to early wound healing in human gingival fibroblasts","volume":"47","author":"J Bi","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"10","key":"pone.0351640.ref055","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1902\/jop.2012.120477","article-title":"Oral neutrophils display a site-specific phenotype characterized by expression of T-cell receptors","volume":"84","author":"FS Lakschevitz","year":"2013","journal-title":"J Periodontol"},{"issue":"2","key":"pone.0351640.ref056","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cyto.2014.10.018","article-title":"Interleukin-1 beta enhances human multipotent mesenchymal stromal cell proliferative potential and their ability to maintain hematopoietic precursor cells","volume":"71","author":"AE Bigildeev","year":"2015","journal-title":"Cytokine"},{"issue":"1","key":"pone.0351640.ref057","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/omi.12484","article-title":"Topology and functional characterization of major outer membrane proteins of Treponema maltophilum and Treponema lecithinolyticum","volume":"40","author":"NK Anselmi","year":"2025","journal-title":"Mol Oral Microbiol"},{"issue":"3","key":"pone.0351640.ref058","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2217\/fca-2016-0063","article-title":"Elevation of plasma oncostatin M in heart failure","volume":"13","author":"D Gruson","year":"2017","journal-title":"Future Cardiol"},{"key":"pone.0351640.ref059","first-page":"100829","article-title":"Oncostatin M is a novel biomarker for coronary artery disease - A possibility as a screening tool of silent myocardial ischemia for diabetes mellitus","volume":"35","author":"S Ikeda","year":"2021","journal-title":"Int J Cardiol Heart Vasc"},{"key":"pone.0351640.ref060","doi-asserted-by":"crossref","first-page":"594603","DOI":"10.3389\/fimmu.2020.594603","article-title":"Myeloid Ezh2 deficiency limits atherosclerosis development","volume":"11","author":"AE Neele","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"pone.0351640.ref061","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s44161-021-00002-8","article-title":"Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease","volume":"1","author":"D Rohde","year":"2022","journal-title":"Nat Cardiovasc 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Res"},{"issue":"4","key":"pone.0351640.ref068","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies","volume":"27","author":"L Claesson-Welsh","year":"2021","journal-title":"Trends Mol Med"},{"issue":"4","key":"pone.0351640.ref069","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.186.4.517","article-title":"Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions","volume":"186","author":"JR Allport","year":"1997","journal-title":"J Exp Med"},{"issue":"6","key":"pone.0351640.ref070","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00109.2006","article-title":"TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn 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Isolated From Blood and Sites of Sterile Inflammation","volume":"23","author":"S Ghosh","year":"2024","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"pone.0351640.ref074","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.1038\/s41598-024-56163-6","article-title":"Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures","volume":"14","author":"G Sollberger","year":"2024","journal-title":"Sci Rep"},{"issue":"2","key":"pone.0351640.ref075","first-page":"153","article-title":"Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States","volume":"15","author":"N Tran","year":"2022","journal-title":"Am J Biomed Sci Res"},{"issue":"1","key":"pone.0351640.ref076","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets","volume":"28","author":"A Janaszak-Jasiecka","year":"2023","journal-title":"Cell Mol Biol Lett"},{"issue":"6","key":"pone.0351640.ref077","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/01.ATV.0000125114.88079.96","article-title":"Dysfunction of endothelial nitric oxide synthase and atherosclerosis","volume":"24","author":"S Kawashima","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"pone.0351640.ref078","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.abb.2006.02.017","article-title":"Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age","volume":"454","author":"AR Smith","year":"2006","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"pone.0351640.ref079","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1164\/ajrccm.164.4.2101023","article-title":"Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers","volume":"164","author":"JA Barber\u00e0","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"25","key":"pone.0351640.ref080","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.97.25.2494","article-title":"Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis","volume":"97","author":"BS Oemar","year":"1998","journal-title":"Circulation"},{"issue":"1","key":"pone.0351640.ref081","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1172\/JCI119508","article-title":"Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules","volume":"100","author":"V Modur","year":"1997","journal-title":"J Clin Invest"},{"issue":"4895","key":"pone.0351640.ref082","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.2466335","article-title":"Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins","volume":"243","author":"MP Bevilacqua","year":"1989","journal-title":"Science"},{"issue":"4984","key":"pone.0351640.ref083","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.1701274","article-title":"ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex","volume":"250","author":"ML Phillips","year":"1990","journal-title":"Science"},{"key":"pone.0351640.ref084","doi-asserted-by":"crossref","first-page":"1401399","DOI":"10.3389\/fimmu.2024.1401399","article-title":"E-selectin in vascular pathophysiology","volume":"15","author":"J Zhang","year":"2024","journal-title":"Front Immunol"},{"issue":"4","key":"pone.0351640.ref085","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0002-9440(10)62538-2","article-title":"Exclusive neutrophil recruitment with oncostatin M in a human system","volume":"159","author":"SM Kerfoot","year":"2001","journal-title":"Am J Pathol"},{"issue":"2","key":"pone.0351640.ref086","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1182\/blood-2004-12-4942","article-title":"ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow","volume":"106","author":"L Yang","year":"2005","journal-title":"Blood"},{"issue":"5","key":"pone.0351640.ref087","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1161\/01.ATV.0000016249.96529.B8","article-title":"Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study","volume":"22","author":"IM van der Meer","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9096","key":"pone.0351640.ref088","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0140-6736(97)09032-6","article-title":"Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men","volume":"351","author":"PM Ridker","year":"1998","journal-title":"Lancet"},{"issue":"11","key":"pone.0351640.ref089","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jnen\/60.11.1087","article-title":"Effects of oncostatin M on human cerebral endothelial cells and expression in inflammatory brain lesions","volume":"60","author":"K Ruprecht","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"pone.0351640.ref090","doi-asserted-by":"crossref","first-page":"317503","DOI":"10.1155\/2013\/317503","article-title":"Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells","volume":"2013","author":"D Schnittker","year":"2013","journal-title":"Mediators Inflamm"},{"issue":"11","key":"pone.0351640.ref091","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/jcpe.14055","article-title":"The Role of Interleukin-8 in the Estimation of Responsiveness to Steps 1 and 2 of Periodontal Therapy","volume":"51","author":"CV Bumm","year":"2024","journal-title":"J Clin Periodontol"},{"issue":"22","key":"pone.0351640.ref092","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006932","article-title":"Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis","volume":"96","author":"LS Finoti","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"pone.0351640.ref093","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1902\/jop.2000.71.6.929","article-title":"Interleukin-8 and granulocyte elastase in gingival crevicular fluid in relation to periodontopathogens in untreated adult periodontitis","volume":"71","author":"L Jin","year":"2000","journal-title":"J Periodontol"},{"issue":"1","key":"pone.0351640.ref094","doi-asserted-by":"crossref","first-page":"8159","DOI":"10.1038\/s41598-022-12358-3","article-title":"Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules","volume":"12","author":"T Hiyoshi","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0351640.ref095","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/prd.12629","article-title":"Serum cytokines in periodontal diseases","volume":"98","author":"P Ahmad","year":"2025","journal-title":"Periodontol 2000"},{"key":"pone.0351640.ref096","doi-asserted-by":"crossref","first-page":"10742484241248046","DOI":"10.1177\/10742484241248046","article-title":"The Role of JAK\/STAT Signaling Pathway and Its Downstream Influencing Factors in the Treatment of Atherosclerosis","volume":"29","author":"X Zhang","year":"2024","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"pone.0351640.ref097","doi-asserted-by":"crossref","first-page":"36790","DOI":"10.1038\/srep36790","article-title":"Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice","volume":"6","author":"R Wang","year":"2016","journal-title":"Sci Rep"},{"issue":"22","key":"pone.0351640.ref098","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.7150\/thno.35528","article-title":"Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis","volume":"9","author":"Q Chen","year":"2019","journal-title":"Theranostics"},{"issue":"6","key":"pone.0351640.ref099","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jtcvs.2004.06.046","article-title":"Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure","volume":"128","author":"MF Berry","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"pone.0351640.ref100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156562","article-title":"Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction","volume":"11","author":"M Kanda","year":"2016","journal-title":"PLoS One"},{"issue":"52","key":"pone.0351640.ref101","doi-asserted-by":"crossref","first-page":"20181","DOI":"10.1074\/jbc.RA118.004375","article-title":"The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice","volume":"293","author":"JM Adrian-Segarra","year":"2018","journal-title":"J Biol Chem"},{"issue":"1","key":"pone.0351640.ref102","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/ijms23010353","article-title":"Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice","volume":"23","author":"H L\u00f6rchner","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"pone.0351640.ref103","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ceb.2010.07.006","article-title":"VE-cadherin: at the front, center, and sides of endothelial cell organization and function","volume":"22","author":"ES Harris","year":"2010","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"pone.0351640.ref104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0317110","article-title":"Unveiling endothelial cell border heterogeneity: VE-cadherin adherens junction stratification by deep convolutional neural networks","volume":"20","author":"RJ Postma","year":"2025","journal-title":"PLoS One"},{"key":"pone.0351640.ref105","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1038\/ncomms11017","article-title":"VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread","volume":"7","author":"X Li","year":"2016","journal-title":"Nat Commun"},{"issue":"2","key":"pone.0351640.ref106","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00401-022-02445-0","article-title":"Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity","volume":"144","author":"D Hermans","year":"2022","journal-title":"Acta Neuropathol"},{"issue":"12","key":"pone.0351640.ref107","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1038\/sj.jid.5700461","article-title":"A characteristic subset of psoriasis-associated genes is induced by oncostatin-M in reconstituted epidermis","volume":"126","author":"A Gazel","year":"2006","journal-title":"J Invest Dermatol"},{"issue":"9","key":"pone.0351640.ref108","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/JPER.24-0007","article-title":"Gingipain and oncostatin M synergistically disrupt kidney tight junctions in periodontitis-associated acute kidney injury","volume":"95","author":"W Wei","year":"2024","journal-title":"J Periodontol"},{"issue":"4","key":"pone.0351640.ref109","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1021\/acs.jproteome.8b00860","article-title":"Localization of Outer Membrane Proteins in Treponema denticola by Quantitative Proteome Analyses of Outer Membrane Vesicles and Cellular Fractions","volume":"18","author":"PD Veith","year":"2019","journal-title":"J Proteome Res"},{"issue":"11","key":"pone.0351640.ref110","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00553-19","article-title":"The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils","volume":"87","author":"MM Jones","year":"2019","journal-title":"Infect Immun"},{"issue":"6","key":"pone.0351640.ref111","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/cyto.2002.1023","article-title":"Oncostatin M production by human dendritic cells in response to bacterial products","volume":"17","author":"T Suda","year":"2002","journal-title":"Cytokine"},{"issue":"3","key":"pone.0351640.ref112","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10620-010-1341-z","article-title":"Helicobacter pylori induces expression and secretion of oncostatin M in macrophages in vitro","volume":"56","author":"Z Zeaiter","year":"2011","journal-title":"Dig Dis Sci"},{"issue":"3","key":"pone.0351640.ref113","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s42770-021-00490-7","article-title":"Helicobacter pylori outer membrane vesicles induce expression and secretion of oncostatin M in AGS gastric cancer cells","volume":"52","author":"M Zoaiter","year":"2021","journal-title":"Braz J Microbiol"},{"issue":"627","key":"pone.0351640.ref114","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf8188","article-title":"Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma","volume":"14","author":"SE Headland","year":"2022","journal-title":"Sci Transl Med"},{"issue":"6","key":"pone.0351640.ref115","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1165\/rcmb.2007-0365OC","article-title":"Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia","volume":"38","author":"LJ Quinton","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"13","key":"pone.0351640.ref116","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1128\/JVI.00502-08","article-title":"Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing","volume":"82","author":"J Dumortier","year":"2008","journal-title":"J Virol"},{"issue":"1","key":"pone.0351640.ref117","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4049\/jimmunol.181.1.698","article-title":"Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage","volume":"181","author":"G Chan","year":"2008","journal-title":"J Immunol"},{"issue":"15","key":"pone.0351640.ref118","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1073\/pnas.0307639101","article-title":"Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes","volume":"101","author":"R Seshadri","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"25","key":"pone.0351640.ref119","doi-asserted-by":"crossref","first-page":"15661","DOI":"10.1074\/jbc.273.25.15661","article-title":"Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides","volume":"273","author":"CP Schultz","year":"1998","journal-title":"J Biol Chem"},{"issue":"25","key":"pone.0351640.ref120","doi-asserted-by":"crossref","first-page":"22041","DOI":"10.1074\/jbc.M010481200","article-title":"Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation","volume":"276","author":"B Opitz","year":"2001","journal-title":"J Biol Chem"},{"issue":"3","key":"pone.0351640.ref121","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1128\/IAI.67.3.1180-1186.1999","article-title":"Activation of murine macrophages by lipoprotein and lipooligosaccharide of Treponema denticola","volume":"67","author":"G Rosen","year":"1999","journal-title":"Infect Immun"},{"issue":"9","key":"pone.0351640.ref122","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1128\/IAI.00488-09","article-title":"Involvement of Toll-like receptors 2 and 4 in the innate immune response to Treponema denticola and its outer sheath components","volume":"77","author":"G Nussbaum","year":"2009","journal-title":"Infect Immun"},{"issue":"1","key":"pone.0351640.ref123","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1128\/IAI.71.1.226-233.2003","article-title":"Induction of osteoclastogenesis and matrix metalloproteinase expression by the lipooligosaccharide of Treponema denticola","volume":"71","author":"B-K Choi","year":"2003","journal-title":"Infect Immun"},{"issue":"5","key":"pone.0351640.ref124","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.4049\/jimmunol.165.5.2683","article-title":"Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids","volume":"165","author":"NW Schr\u00f6der","year":"2000","journal-title":"J Immunol"},{"issue":"7","key":"pone.0351640.ref125","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"U F\u00f6rstermann","year":"2012","journal-title":"Eur Heart J"},{"issue":"9","key":"pone.0351640.ref126","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/glia.20989","article-title":"IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia","volume":"58","author":"BJ Baker","year":"2010","journal-title":"Glia"},{"issue":"1","key":"pone.0351640.ref127","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/glia.22739","article-title":"Analysis of IL-6\/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M","volume":"63","author":"M-P 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