{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:57:13Z","timestamp":1781805433628,"version":"3.54.5"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10150511910036"],"award-info":[{"award-number":["10150511910036"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health, Welfare and Sports to the Centre of Infectious Disease Control","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                      (chlamydia) infection control could be more effective if focused on morbidity- rather than prevalence reduction. A predictive test, identifying those at higher risk for chlamydia-subfertility, could be developed to enhance targeted chlamydia control. However, do young adults with a uterus (hereafter \u201cyoung adults\u201d) want to know their subfertility risk?\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A sequential mixed methods study was conducted among young adults in the Netherlands to explore perspectives on chlamydia, subfertility, and a potential subfertility test. Five focus groups with Sexual Health Center (SHC) visitors were held to identify potential benefits, barriers, and requirements; results were analysed thematically and used to inform a questionnaire. This questionnaire was distributed online via SHCs and social media. Descriptive statistics and modified Poisson regression were used to assess benefits and barriers of learning one's subfertility risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen young adults participated in the focus groups, and the resulting themes informed the questionnaire. These included perceived benefits (mental preparation, anticipation, reassurance after a \u201cno increased risk\u201d result), perceived barriers (mental burden of an \u201cincreased risk\u201d result, need for blood sampling), and requirements (accuracy, accessibility, follow-up). The questionnaire was completed by 426 participants (median age 22, IQR 20\u201324). High perceived susceptibility was reported by 11% for chlamydia and 23% for chlamydia\u2011related subfertility; perceived severity was high for chlamydia and chlamydia-related subfertility, 75% and 88%, respectively. Willingness to use a risk test was 78%. Relief after a \u201cno increased risk\u201d result was expected by 89%, while an increased\u2011risk result was expected to enhance preparedness (86%) and elicit worry (83%). Additional considerations included motivation for safer sex, negative effects on relationships, and questioning the value of knowing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Young adults are concerned about chlamydia\u2011related subfertility, resulting in high willingness to use a risk test. The expected benefits and barriers should be carefully considered in test development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0351874","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:34:01Z","timestamp":1781804041000},"page":"e0351874","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Young adults\u2019 perspectives on chlamydia-related subfertility and a potential predictive subfertility test: A mixed-methods study in the Netherlands"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-6198","authenticated-orcid":true,"given":"Bernice M.","family":"Hoenderboom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00efe W.","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte M. 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