{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:50:18Z","timestamp":1782237018578,"version":"3.54.5"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Objective<\/jats:title>\n This study aimed to review the scientific literature on the effects of cancer treatment-related oral complications on the quality of life and well-being of children surviving cancer. This study updates a previous review, from 2012, evaluating the oral health related quality of life and well-being of childhood cancer survivors and exploring the extent to which children\u2019s perspectives are considered in research.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We used a scoping review methodology informed by established frameworks: Arksey and O\u2019Malley, Levac et al. and the Joanna Briggs Institute. Articles were retrieved from five electronic databases (MEDLINE\/PubMed, Scopus, Embase, Web of Science, and PsychInfo) using a predefined search strategy. Screening and study selection were performed independently by two reviewers using Rayyan software (QCRI), with a third reviewer resolving disagreements. Reporting followed the PRISMA-ScR guidelines. Inclusion criteria included articles focused on the impact of oral complications on the quality of life and well-being of child cancer survivors (aged 0\u201317 years at the time of diagnosis), written in English or French, and published from 2012\u20132025. Exclusion criteria included articles involving non-childhood cancers, and with non-specific disease categories. The protocol for this review was published in\n PLOS ONE<\/jats:italic>\n (\n https:\/\/doi.org\/10.1371\/journal.pone.0290364<\/jats:ext-link>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 79 articles were included in this scoping review. The majority of studies had quantitative designs. In contrast to the original review, a substantial number of studies (47) reported children-reported symptoms and completed assessment tools rather than relying solely on their parents and health care providers to provide this information. Furthermore, since the original review, reporting of oral health-related quality of life (OHRQoL) measures has increased, however they were reported in a limited number of studies.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our review suggests that there is growing implementation of patient-reported outcomes and subjective measures of OHRQoL in assessing oral complications in pediatric cancer patients. Future studies should incorporate qualitative approaches to capture children\u2019s or parents\u2019 perspectives on cancer therapy, thereby complementing quantitative findings and providing a more comprehensive understanding of the multifaceted impact of oral complications on children\u2019s quality of life.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0352194","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:23:41Z","timestamp":1782235421000},"page":"e0352194","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of cancer therapy-related oral complications on the quality of life and well-being of childhood cancer survivors: A scoping review"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5875-3131","authenticated-orcid":true,"given":"Nona","family":"Attaran Kakhki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorva","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Balador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco A.","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Ferraz Dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-827X","authenticated-orcid":true,"given":"Mary Ellen","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"pone.0352194.ref001","author":"IARC","year":"2022"},{"key":"pone.0352194.ref002","author":"Government of C","year":"2025"},{"issue":"2","key":"pone.0352194.ref003","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1002\/cam4.5009","article-title":"Global incidence, mortality and temporal trends of cancer in children: A joinpoint regression analysis","volume":"12","author":"J Huang","year":"2023","journal-title":"Cancer Med"},{"key":"pone.0352194.ref004","article-title":"Childhood cancer survival in Africa, Asia, Latin America and the Caribbean, during 2008-2017 (SURVCAN-3): a population-based benchmarking study of 16\u2009821 children","author":"DS Daltveit","year":"2025","journal-title":"J Natl Cancer Inst"},{"key":"pone.0352194.ref005","year":"2021"},{"issue":"4","key":"pone.0352194.ref006","first-page":"566","article-title":"Prevention and Treatment of Oral Complications in Hematologic Childhood Cancer Patients: An Update","volume":"9","author":"A Ferr\u00e1ndez-Pujante","year":"2022","journal-title":"Children (Basel)"},{"key":"pone.0352194.ref007","author":"American Society of Clinical Oncology","year":"2022"},{"key":"pone.0352194.ref008","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/B978-0-12-821085-7.00009-9","article-title":"Oral tissue regeneration: Current status and future perspectives","volume-title":"Regenerated Organs","author":"M Jose","year":"2021"},{"issue":"1","key":"pone.0352194.ref009","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0973-1075.97343","article-title":"Oral health in children with leukemia","volume":"18","author":"VP Mathur","year":"2012","journal-title":"Indian J Palliat Care"},{"issue":"3","key":"pone.0352194.ref010","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/hematolrep15030051","article-title":"Oral Manifestations: A Warning-Sign in Children with Hematological Disease Acute Lymphocytic Leukemia","volume":"15","author":"SC Soares","year":"2023","journal-title":"Hematol Rep"},{"issue":"1","key":"pone.0352194.ref011","first-page":"41","article-title":"Aspectos odontoestomatol\u00f3gicos en oncolog\u00eda infantil","volume":"10","author":"MC Cabrerizo Merino","year":"2005","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"11","key":"pone.0352194.ref012","first-page":"236","article-title":"Chemotherapy associated side effects among children with cancer","volume":"2","author":"NCS Rawat","year":"2021","journal-title":"International Journal of Health Sciences and Research"},{"key":"pone.0352194.ref013","author":"C Noronha","year":"2012"},{"issue":"3","key":"pone.0352194.ref014","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/joor.13040","article-title":"Foundations of oral health\u2010related quality of life","volume":"48","author":"MT John","year":"2020","journal-title":"J of Oral Rehabilitation"},{"issue":"1","key":"pone.0352194.ref015","doi-asserted-by":"crossref","DOI":"10.4314\/ajoh.v1i1.31299","article-title":"Improvement of oral health in Africa in the 21st century - 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