{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:29:40Z","timestamp":1782934180712,"version":"3.54.5"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405158"],"award-info":[{"award-number":["82405158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2026NSFSC1818"],"award-info":[{"award-number":["2026NSFSC1818"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2025ZNSFSC1818"],"award-info":[{"award-number":["2025ZNSFSC1818"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity caused by a high-fat diet (HFD) is known to disrupt metabolic homeostasis and circadian rhythms. Pachymic acid (PA), a bioactive triterpenoid, exhibits anti-inflammatory, antihyperglycemic, antihyperlipidemic, and sedative-hypnotic properties, though its role in circadian regulation remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed PA\u2019s impact on metabolic dysfunction (glucose\/lipid profiles), systemic inflammation using biochemical assays, ELISA, Oil Red O staining. Circadian parameters were evaluated via 24-h serum melatonin and core body temperature. Hepatic circadian gene oscillations and mechanistic pathways were analyzed through time-series RNA sequencing, bioinformatics, qPCR, and Western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PA intervention attenuated obesity-related phenotypes, including reduced body weight, improved glucose\/lipid metabolism, and restored physiological rhythms of melatonin and body temperature. And hepatic gene oscillation patterns were realigned to circadian synchrony. Mechanistically, PA ameliorated liver inflammation by modulating the sphingolipid pathway, specifically via\n                      <jats:italic>S1PR4\/TRAF2<\/jats:italic>\n                      signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings illustrate PA\u2019s role in mitigating metabolic and circadian disruptions in obesity, highlighting the sphingolipid pathway as a tissue-specific target for circadian modulation. This study provides novel insights into therapeutic strategies for obesity-associated circadian disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0352604","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:45:24Z","timestamp":1782927924000},"page":"e0352604","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pachymic acid alleviates circadian rhythm disorders in high-fat diet-induced obesity mice via the sphingolipid 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Chen","year":"2021","journal-title":"J Genet Genomics"},{"key":"pone.0352604.ref032","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: Biological systems database as a model of the real world","volume":"53","author":"M Kanehisa","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pone.0352604.ref033","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"M Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"pone.0352604.ref034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072457","article-title":"Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting","volume":"8","author":"SL Eaton","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"pone.0352604.ref035","article-title":"Obesity: A chronic low-grade inflammation and its markers","volume":"14","author":"D Khanna","year":"2022","journal-title":"Cureus"},{"key":"pone.0352604.ref036","doi-asserted-by":"crossref","first-page":"1002574","DOI":"10.3389\/fnut.2022.1002574","article-title":"The nutritional functions of dietary sphingomyelin and its applications in food","volume":"9","author":"F Yang","year":"2022","journal-title":"Front Nutr"},{"key":"pone.0352604.ref037","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10592","article-title":"TRAF2 regulates TNF and NF-\u03baB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1","volume":"4","author":"N Etemadi","year":"2015","journal-title":"Elife"},{"key":"pone.0352604.ref038","doi-asserted-by":"crossref","first-page":"155158","DOI":"10.1016\/j.metabol.2022.155158","article-title":"Chronic circadian disruption on a high-fat diet impairs glucose tolerance","volume":"130","author":"K-M Zitting","year":"2022","journal-title":"Metabolism"},{"key":"pone.0352604.ref039","doi-asserted-by":"crossref","first-page":"505249","DOI":"10.3389\/fphar.2020.505249","article-title":"Phytochemistry and pharmacological activities of Wolfiporia cocos (FA Wolf) Ryvarden & Gilb","volume":"11","author":"A Nie","year":"2020","journal-title":"Frontiers in Pharmacology"},{"issue":"4","key":"pone.0352604.ref040","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/biof.1734","article-title":"Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis","volume":"47","author":"Z Feng","year":"2021","journal-title":"Biofactors"},{"key":"pone.0352604.ref041","doi-asserted-by":"crossref","first-page":"110854","DOI":"10.1016\/j.intimp.2023.110854","article-title":"Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6\/NF-\u03baB signal axis","volume":"124","author":"Y Wu","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"pone.0352604.ref042","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1002\/ptr.5402","article-title":"Pachymic acid induces apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP family members","volume":"29","author":"J-W Jeong","year":"2015","journal-title":"Phytother Res"},{"key":"pone.0352604.ref043","doi-asserted-by":"crossref","first-page":"116671","DOI":"10.1016\/j.foodres.2025.116671","article-title":"Poria cocos polysaccharides alleviate obesity-related adipose tissue insulin resistance via gut microbiota-derived short-chain fatty acids activation of FGF21\/PI3K\/AKT signaling","volume":"215","author":"W Liu","year":"2025","journal-title":"Food Res Int"},{"issue":"9","key":"pone.0352604.ref044","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3390\/healthcare10091616","article-title":"The related metabolic diseases and treatments of obesity","volume":"10","author":"M Yang","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"pone.0352604.ref045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-319-48382-5_2","article-title":"Circadian rhythms in diet-induced obesity","volume":"960","author":"A Engin","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"pone.0352604.ref046","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00424-020-02381-6","article-title":"Metabolic implications of circadian disruption","volume":"472","author":"N Fatima","year":"2020","journal-title":"Pflugers Arch"},{"issue":"4","key":"pone.0352604.ref047","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.3390\/ijms24043392","article-title":"Circadian rhythms disrupted by light at night and mistimed food intake alter hormonal rhythms and metabolism","volume":"24","author":"OH 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