{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:05:50Z","timestamp":1783965950831,"version":"3.55.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy at Ho Chi Minh City","award":["002-NNC\/2025\/H\u0110-\u0110HYD"],"award-info":[{"award-number":["002-NNC\/2025\/H\u0110-\u0110HYD"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Several studies have investigated colorectal neoplasia (CRN) in Vietnamese patients who present with lower gastrointestinal symptoms. However, data on subjects without symptoms is limited. This study aimed to determine the prevalence and risk factors for CRN in asymptomatic Vietnamese adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, cross-sectional, single-center study. Participants were consecutively recruited from asymptomatic individuals who were self-selected to undergo self-funded screening colonoscopy. CRN was defined as the presence of adenoma, sessile serrated lesions, or colorectal cancer. Advanced CRN included adenoma\u2009\u2265\u20091 cm, with villous features or high-grade dysplasia; sessile serrated lesion\u2009\u2265\u20091 cm or with dysplasia; traditional serrated adenoma; or colorectal cancer. Multivariable logistic regression was performed to identify independent risk factors for CRN, adjusting for age, sex, BMI, family history of colorectal cancer, smoking status, and alcohol consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 714 patients, with a median age of 51 (18\u201379 years) and a female-to-male ratio of 1:1.46. In this screening-attending cohort, the prevalence of overall CRN and advanced CRN were 26.2% and 9.0%, respectively. In the multivariate analysis, factors significantly associated with CRN included increasing age per 10-year increment (odds ratio [OR]: 1.76; 95% confidence interval [CI]: 1.47\u20132.11; p\u2009&lt;\u20090.001), body mass index\u2009\u2265\u200923 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (OR: 1.70; 95% CI: 1.16\u20132.50; p\u2009=\u20090.006), alcohol consumption (OR: 1.83, 95% CI: 1.10\u20133.04, p\u2009=\u20090.020), and family history of colorectal cancer (OR: 2.43; 95% CI: 1.36\u20134.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CRN was prevalent in this self-selected screening-attending cohort in a private clinical setting. Increasing age, overweight, and family history of colorectal cancer were independent factors associated with CRN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0352998","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:32:07Z","timestamp":1783963927000},"page":"e0352998","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and risk factors for colorectal neoplasia in a self-selected Vietnamese screening cohort undergoing self-funded colonoscopy"],"prefix":"10.1371","volume":"21","author":[{"given":"Huong Thi Thuy","family":"To","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhu Thi Hanh","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Nguyen Diem","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Thi Anh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thu Dang Anh","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dat Quoc","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Hiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-921X","authenticated-orcid":true,"given":"Duc Trong","family":"Quach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"pone.0352998.ref001","volume-title":"Global cancer observatory: cancer today","author":"J Ferlay","year":"2024"},{"issue":"7","key":"pone.0352998.ref002","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.3390\/cancers15071948","article-title":"Effectiveness of Colorectal Cancer (CRC) screening on all-cause and CRC-specific mortality reduction: a systematic review and meta-analysis","volume":"15","author":"S Zheng","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"11","key":"pone.0352998.ref003","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1136\/gutjnl-2022-327377","article-title":"Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance","volume":"71","author":"JJY Sung","year":"2022","journal-title":"Gut"},{"issue":"5","key":"pone.0352998.ref004","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.7314\/APJCP.2012.13.5.1767","article-title":"Clinical, endoscopic and pathogical characteristics of early-onset colorectal cancer in Vietnamese","volume":"13","author":"DT Quach","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"issue":"10207","key":"pone.0352998.ref005","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"E Dekker","year":"2019","journal-title":"Lancet"},{"issue":"20","key":"pone.0352998.ref006","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.3748\/wjg.v23.i20.3632","article-title":"Colorectal cancer population screening programs worldwide in 2016: an update","volume":"23","author":"M Navarro","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"2","key":"pone.0352998.ref007","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.giec.2021.12.008","article-title":"Risk factors for colorectal polyps and cancer","volume":"32","author":"JA Sninsky","year":"2022","journal-title":"Gastrointest Endosc Clin N Am"},{"issue":"1","key":"pone.0352998.ref008","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1186\/s12885-022-10141-1","article-title":"Modifiable lifestyle factors have a larger contribution to colorectal neoplasms than family history","volume":"22","author":"S Wang","year":"2022","journal-title":"BMC Cancer"},{"issue":"1","key":"pone.0352998.ref009","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1053\/j.gastro.2021.10.007","article-title":"Updates on age to start and stop colorectal cancer screening: recommendations from the U.S. multi-society task force on colorectal cancer","volume":"162","author":"SG Patel","year":"2022","journal-title":"Gastroenterology"},{"issue":"4","key":"pone.0352998.ref010","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/den.13972","article-title":"Colonoscopy screening and surveillance guidelines","volume":"33","author":"Y Saito","year":"2021","journal-title":"Dig Endosc"},{"issue":"12","key":"pone.0352998.ref011","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1136\/gutjnl-2020-322545","article-title":"Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers","volume":"70","author":"H-M Chiu","year":"2021","journal-title":"Gut"},{"issue":"10","key":"pone.0352998.ref012","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1136\/gutjnl-2014-309086","article-title":"Colorectal cancer screening: a global overview of existing programmes","volume":"64","author":"EH Schreuders","year":"2015","journal-title":"Gut"},{"key":"pone.0352998.ref013","first-page":"3858","article-title":"Age distribution, gender, endoscopic and pathologic characteristics of advanced colorectal polyps","volume":"62","author":"NTHV Tham Thi Do","year":"2021","journal-title":"The Vietnam Association of Gastroenterology"},{"key":"pone.0352998.ref014","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.gie.2008.05.057","article-title":"The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented research","volume":"69","author":"EJ Lai","year":"2009","journal-title":"Gastrointest Endosc"},{"issue":"9403","key":"pone.0352998.ref015","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","author":"WHO Expert Consultation","year":"2004","journal-title":"Lancet"},{"issue":"9","key":"pone.0352998.ref016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223168","article-title":"Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load","volume":"14","author":"D Goldwater","year":"2019","journal-title":"PLoS One"},{"issue":"6","key":"pone.0352998.ref017","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1055\/s-2005-861352","article-title":"Update on the paris classification of superficial neoplastic lesions in the digestive tract","volume":"37","author":"Group Endoscopic Classification Review","year":"2005","journal-title":"Endoscopy"},{"issue":"3","key":"pone.0352998.ref018","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.05.006","article-title":"Validation of a simple classification system for endoscopic diagnosis of small colorectal polyps using narrow-band imaging","volume":"143","author":"DG Hewett","year":"2012","journal-title":"Gastroenterology"},{"issue":"3","key":"pone.0352998.ref019","doi-asserted-by":"crossref","first-page":"311","DOI":"10.14309\/ajg.0000000000000467","article-title":"Advanced colorectal polyps on colonoscopy: a trigger for earlier screening of family members","volume":"115","author":"CL Molmenti","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"pone.0352998.ref020","volume-title":"Report on the Main Results of the 2024 Vietnam Intercensal Population and Housing Survey","author":"General Statistics Office (GSO)","year":"2024"},{"issue":"2","key":"pone.0352998.ref021","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1053\/j.gastro.2019.10.007","article-title":"International perspective on the burden of colorectal cancer and public health effects","volume":"158","author":"L Rabeneck","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"pone.0352998.ref022","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MCG.0000000000000102","article-title":"Development and validation of a risk stratification-based screening model for predicting colorectal advanced neoplasia in Korea","volume":"49","author":"DH Kim","year":"2015","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"pone.0352998.ref023","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jgh.13835","article-title":"A modified colorectal screening score for prediction of advanced neoplasia: a prospective study of 5744 subjects","volume":"33","author":"JJY Sung","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"pone.0352998.ref024","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/jgh.16523","article-title":"Performance of the Asia-Pacific Colorectal Screening score in stratifying the risk of advanced colorectal neoplasia: a meta-analysis and systematic review","volume":"39","author":"MN Luu","year":"2024","journal-title":"J Gastroenterol Hepatol"},{"issue":"7","key":"pone.0352998.ref025","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.gie.2006.12.065","article-title":"Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey","volume":"65","author":"J-S Byeon","year":"2007","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"pone.0352998.ref026","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/jgh.13821","article-title":"Asia-Pacific colorectal screening score: a useful tool to stratify risk for colorectal advanced neoplasms in Vietnamese patients with irritable bowel syndrome","volume":"33","author":"DT Quach","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"pone.0352998.ref027","doi-asserted-by":"crossref","first-page":"577","DOI":"10.5946\/ce.2024.265","article-title":"Efficacy of additional tissue sections for diminutive colorectal adenomas pathologically diagnosed as normal mucosa: a retrospective, cross-sectional study in Japan","volume":"58","author":"T Ishii","year":"2025","journal-title":"Clin Endosc"},{"issue":"1","key":"pone.0352998.ref028","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5009\/gnl.2009.3.1.35","article-title":"Colorectal neoplasm in asymptomatic average-risk koreans: the KASID prospective multicenter colonoscopy survey","volume":"3","author":"H-W Park","year":"2009","journal-title":"Gut Liver"},{"issue":"12","key":"pone.0352998.ref029","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1111\/j.1572-0241.2005.00352.x","article-title":"Race, gender, and colorectal cancer screening","volume":"100","author":"D Lieberman","year":"2005","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"pone.0352998.ref030","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/ajg.2012.180","article-title":"Body mass index category as a risk factor for colorectal adenomas: a systematic review and meta-analysis","volume":"107","author":"K Okabayashi","year":"2012","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"pone.0352998.ref031","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10654-017-0336-x","article-title":"Association between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects","volume":"33","author":"MC-S Wong","year":"2018","journal-title":"Eur J Epidemiol"},{"issue":"8","key":"pone.0352998.ref032","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1161\/ATVBAHA.111.241927","article-title":"Growth signals, inflammation, and vascular perturbations: mechanistic links between obesity, metabolic syndrome, and cancer","volume":"32","author":"SD Hursting","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9403","key":"pone.0352998.ref033","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","author":"WHO Expert Consultation","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"pone.0352998.ref034","doi-asserted-by":"crossref","first-page":"105","DOI":"10.31557\/APJCP.2019.20.1.105","article-title":"Overweight as an additional risk factor for colorectal neoplasia in lean population","volume":"20","author":"S Jangsirikul","year":"2019","journal-title":"Asian Pac J Cancer Prev"},{"issue":"2","key":"pone.0352998.ref035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.15430\/JCP.2013.18.2.144","article-title":"Body mass index as a predictor of advanced colorectal neoplasia","volume":"18","author":"HJ Kwon","year":"2013","journal-title":"J Cancer Prev"},{"issue":"11","key":"pone.0352998.ref036","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/ijc.33757","article-title":"Association between body mass index and colorectal adenomas: findings from a case-control study in Vietnam","volume":"149","author":"HN Luu","year":"2021","journal-title":"Int J Cancer"},{"issue":"9","key":"pone.0352998.ref037","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/gim.2014.188","article-title":"Family history and the natural history of colorectal cancer: systematic review","volume":"17","author":"NB Henrikson","year":"2015","journal-title":"Genet Med"},{"issue":"1","key":"pone.0352998.ref038","doi-asserted-by":"crossref","first-page":"17457","DOI":"10.1038\/s41598-023-44487-8","article-title":"Family history of cancer as a potential risk factor for colorectal cancer in EMRO countries: a systematic review and meta-analysis","volume":"13","author":"M-H Keivanlou","year":"2023","journal-title":"Sci Rep"},{"issue":"12","key":"pone.0352998.ref039","first-page":"2287","article-title":"Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis","volume":"21","author":"JA Wilschut","year":"2010","journal-title":"Cancer Causes Control"},{"issue":"4","key":"pone.0352998.ref040","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2014.07.006","article-title":"Increased risk of colorectal neoplasia among family members of patients with colorectal cancer: a population-based study in Utah","volume":"147","author":"NJ Samadder","year":"2014","journal-title":"Gastroenterology"},{"issue":"7","key":"pone.0352998.ref041","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ajg.2017.174","article-title":"Colorectal cancer screening: recommendations for physicians and patients from the U.S. multi-society task force on colorectal cancer","volume":"112","author":"DK Rex","year":"2017","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"pone.0352998.ref042","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2018.08.017","article-title":"Clinical practice guideline on screening for colorectal cancer in individuals with a family history of nonhereditary colorectal cancer or adenoma: the canadian association of gastroenterology banff consensus","volume":"155","author":"D Leddin","year":"2018","journal-title":"Gastroenterology"},{"issue":"4","key":"pone.0352998.ref043","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1572-0241.2007.01649.x","article-title":"Obstacles to colorectal cancer screening in Chinese: a study based on the health belief model","volume":"103","author":"JJY Sung","year":"2008","journal-title":"Am J Gastroenterol"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0352998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:32:17Z","timestamp":1783963937000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0352998"}},"subtitle":[],"editor":[{"given":"Chih-Wei","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":43,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0352998","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}