{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:08:20Z","timestamp":1784052500311,"version":"3.55.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project of the Zhejiang Traditional Chinese Medicine Administration","award":["2023ZL259"],"award-info":[{"award-number":["2023ZL259"]}]},{"name":"Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission","award":["2024KY637"],"award-info":[{"award-number":["2024KY637"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Basilar artery occlusion (BAO) is a severe form of ischemic stroke associated with high morbidity and mortality. Whether BAO patients derive similar benefits from CT perfusion (CTP)-guided endovascular treatment (EVT) as those with anterior circulation stroke (ACS) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to compare the efficacy and safety of EVT based on computed tomography (CT) perfusion between patients with BAO and those with ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This analysis was conducted using data from a prospective multicenter Registry on International Stroke Perfusion Imaging. A total of 256 patients with 36 BAO and 220 ACS who received CTP-guided EVT were included. Propensity score matching (PSM) in a 1:2 ratio was performed to adjust for baseline imbalances. Multivariate logistic regression was used to identify independent predictors of mRS 3\u20136 at 90 days as poor functional outcome and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prior to matching, BAO patients had higher baseline NIHSS scores (24.0\u2009\u00b1\u20099.8 vs. 15.2\u2009\u00b1\u20096.4, p\u2009&lt;\u20090.001), smaller ischemic core volumes (8.7\u2009\u00b1\u200911.4 mL vs. 33.2\u2009\u00b1\u200938.9 mL, p\u2009&lt;\u20090.001), and higher mismatch ratios (0.9\u2009\u00b1\u20090.1 vs. 0.7\u2009\u00b1\u20090.2, p\u2009&lt;\u20090.001) than ACS patients. After matching, BAO patients had significantly shorter door-to-reperfusion time (3.2\u2009\u00b1\u20091.1 vs. 4.3\u2009\u00b1\u20092.9 hours, p\u2009=\u20090.007) and lower rates of hemorrhagic transformation (19.4% vs. 48.6%, p\u2009=\u20090.006). Multivariate analysis identified baseline NIHSS score (OR = 1.052, 95% CI: 1.013\u20131.092, p\u2009=\u20090.009) and ASPECT score (OR = 0.813, 95% CI: 0.682\u20130.969, p\u2009=\u20090.021) as independent predictors of poor outcome, while age (OR = 1.037, 95%CI: 1.006\u20131.069, p\u2009=\u20090.020) and baseline NIHSS score (OR = 1.070, 95% CI: 1.024\u20131.119, p\u2009=\u20090.002) were independent predictors of mortality. No significant differences were observed in 90-day functional independence (mRS 0\u20132) or mortality between BAO group and ACS group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite presenting with more severe neurological deficits, BAO patients treated with CTP-guided EVT achieved comparable functional outcomes and mortality to ACS patients, with shorter reperfusion times and fewer hemorrhagic complications. CTP-based selection may facilitate effective EVT in BAO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0353204","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:29:44Z","timestamp":1784050184000},"page":"e0353204","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perfusion imaging findings, and outcomes between computed tomography perfusion selected basilar artery occlusion and anterior circulation stroke patients undergoing endovascular 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