{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:19:48Z","timestamp":1783621188066,"version":"3.55.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background<\/jats:title>\n Post-traumatic hemorrhage is a leading cause of death if not promptly identified and treated. This study aimed to compare the performance of four scoring systems in predicting the need for massive transfusion (MT) in trauma patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective cohort study analyzed data from trauma patients admitted to Sina Hospital in Tehran between July 2021 and December 2024. All trauma patients who received at least one unit of packed red blood cells were included in the study. Patients were evaluated for the need for MT, and four scoring systems were compared between those who did and did not receive MT. The discriminative ability of the Shock Index (SI), Assessment of Blood Consumption (ABC), Revised Assessment of Bleeding and Transfusion (RABT), and Trauma-Associated Severe Hemorrhage (TASH) was evaluated using the concordance index (C-index) and logistic regression models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 329 trauma patients were included, with a mean age of 49.2 (SD\u2009=\u200920.8) years; 244 (74.2%) were male. MT occurred in 36 patients (10.9%). All four scoring systems were significantly associated with the need for MT (p\u2009<\u20090.001) and showed comparable discriminative performance (C-index range: 0.81\u20130.84). At predefined cutoff values, sensitivity ranged from 63.9% to 94.4%, specificity from 60.0% to 94.2%, PPV from 22.4% to 59.5%, and NPV from 95.5% to 98.9%. In univariable logistic regression, an ABC score\u2009\u2265\u20092 was significantly associated with MT (OR: 36.9; 95% CI: 15.6\u201387.3), followed by an RABT score\u2009\u2265\u20092 (OR: 25.5, 95% CI: 11.2\u201358.1) and a TASH score\u2009\u2265\u20096 (OR: 25.2, 95% CI: 5.9\u2013106.9).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n All four scoring systems showed significant associations with the need for MT. These tools may assist clinicians in the early risk stratification of trauma patients; however, given the moderate positive predictive values in this low-prevalence setting, they should be used as adjuncts to clinical judgment rather than as standalone triggers for massive transfusion activation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0353398","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:47:32Z","timestamp":1783619252000},"page":"e0353398","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance of four scoring systems in predicting the need for massive transfusion in Iranian trauma patients"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-1480","authenticated-orcid":true,"given":"Negin","family":"Pouroushaninia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8472-9412","authenticated-orcid":true,"given":"Zahra","family":"Ramezani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Jahangiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3901-1839","authenticated-orcid":true,"given":"Niyousha","family":"Rahimimovaghar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-7340","authenticated-orcid":true,"given":"Vali","family":"Baigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vafa","family":"Rahimi-Movaghar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"pone.0353398.ref001","volume-title":"Noncommunicable diseases country profiles 2014","author":"World Health Organization","year":"2014"},{"issue":"4","key":"pone.0353398.ref002","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2471\/BLT.08.052290","article-title":"Injuries: the neglected burden in developing countries","volume":"87","author":"RA Gosselin","year":"2009","journal-title":"Bull World Health Organ"},{"key":"pone.0353398.ref003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1478-7954-7-9","article-title":"The burden of disease and injury in Iran 2003","volume":"7","author":"M Naghavi","year":"2009","journal-title":"Population health metrics"},{"key":"pone.0353398.ref004","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/trf.15161","article-title":"Outcomes of traumatic hemorrhagic shock and the epidemiology of preventable death from injury","volume":"59","author":"BJ Eastridge","year":"2019","journal-title":"Transfusion"},{"issue":"2","key":"pone.0353398.ref005","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/SLA.0000000000002999","article-title":"Establishing a Regional Trauma Preventable\/Potentially Preventable Death Rate","volume":"271","author":"SA Drake","year":"2020","journal-title":"Ann Surg"},{"issue":"9859","key":"pone.0353398.ref006","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"R Lozano","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"pone.0353398.ref007","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/SLA.0000000000000837","article-title":"Detailed description of all deaths in both the shock and traumatic brain injury hypertonic saline trials of the Resuscitation Outcomes Consortium","volume":"261","author":"SA Tisherman","year":"2015","journal-title":"Ann Surg"},{"key":"pone.0353398.ref008","unstructured":"Centers for Disease Control and Prevention. 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