{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:10:47Z","timestamp":1784139047051,"version":"3.55.0"},"reference-count":105,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R21CA281951-01"],"award-info":[{"award-number":["R21CA281951-01"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this trial was to assess the feasibility, acceptability and safety of a 10-week hybrid (in-clinic and virtual) resistance exercise training RET program with or without CrM in individuals treated for colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-seven participants were randomized to RET plus 5 grams\/day of CrM (EXSUPP; n\u2009=\u200913) or 5 grams\/day corn-starch maltodextrin placebo (EXPLA; n\u2009=\u200914). RET was performed three times per week. Feasibility was assessed through recruitment, retention and fidelity (percentage of prescribed RET and supplementation completed). Acceptability was evaluated using a 5-point Likert scale, and safety was monitored through adverse event reporting. Secondary outcomes (body composition, muscular strength, physical function) were assessed pre- and post-intervention using baseline-adjusted ANCOVA models and focus group interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Registry-based recruitment identified 1378 potentially eligible individuals and 27 of 410 assessed (6.6%) enrolled, highlighting recruitment challenges. Retention was high (24\/27; 88.9%). Adherence to RET and supplementation was strong (both &gt; 85%) with no serious adverse events reported. Participants reported high acceptability for both in person and virtual components. No significant between group differences were observed for secondary outcomes; however, both groups demonstrated modest improvements in muscular strength and short physical performance battery (SPPB) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A hybrid RET program with CrM was feasible, acceptable and well tolerated in individuals with colorectal cancer who were previously treated with chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Implications for Cancer Survivors<\/jats:title>\n                    <jats:p>Hybrid supervised RET is safe, acceptable, and associated with modest improvements in strength and physical function among individuals treated for colorectal cancer. While creatine supplementation did not demonstrate clear additive effects in this pilot trial, further adequately powered studies are warranted.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NCT06420726.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0353630","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:35:31Z","timestamp":1784136931000},"page":"e0353630","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Examining the feasibility and preliminary effects of resistance exercise training and creatine supplementation in individuals treated for colorectal cancer"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-9669","authenticated-orcid":true,"given":"Ciaran M.","family":"Fairman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren G.","family":"Candow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1972-9980","authenticated-orcid":true,"given":"Kylah E.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Bottone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie R.","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-819X","authenticated-orcid":true,"given":"Thomas D.","family":"Cardaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon N.","family":"VanderVeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Angela","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"7","key":"pone.0353630.ref001","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.12998\/wjcc.v8.i7.1188","article-title":"Sarcopenia in patients with colorectal cancer: a comprehensive review","volume":"8","author":"O Vergara-Fernandez","year":"2020","journal-title":"World J Clin Cases"},{"issue":"2","key":"pone.0353630.ref002","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00595-017-1564-0","article-title":"Sarcopenia is an independent predictor of complications after colorectal cancer surgery","volume":"48","author":"R Nakanishi","year":"2018","journal-title":"Surg Today"},{"issue":"12","key":"pone.0353630.ref003","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/codi.14751","article-title":"Is sarcopenia a better predictor of complications than body mass index? Sarcopenia and surgical outcomes in patients with rectal cancer","volume":"21","author":"SB Jochum","year":"2019","journal-title":"Colorectal Dis"},{"issue":"6","key":"pone.0353630.ref004","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jgo.2015.08.005","article-title":"Prevalence of sarcopenia in older patients with colorectal cancer","volume":"6","author":"JR Broughman","year":"2015","journal-title":"J Geriatr Oncol"},{"issue":"5","key":"pone.0353630.ref005","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/annonc\/mdy114","article-title":"Systematic review and meta-analysis of the evidence for oral nutritional intervention on nutritional and clinical outcomes during chemo(radio)therapy: current evidence and guidance for design of future trials","volume":"29","author":"MAE de van der Schueren","year":"2018","journal-title":"Ann Oncol"},{"issue":"2","key":"pone.0353630.ref006","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/jnci\/djaa060","article-title":"Strategies to prevent or remediate cancer and treatment-related aging","volume":"113","author":"JL Guida","year":"2021","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"pone.0353630.ref007","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/jnci\/djz136","article-title":"Measuring aging and identifying aging phenotypes in cancer survivors","volume":"111","author":"JL Guida","year":"2019","journal-title":"J Natl Cancer Inst"},{"key":"pone.0353630.ref008","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fphys.2016.00472","article-title":"Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways","volume":"7","author":"R Barreto","year":"2016","journal-title":"Front Physiol"},{"issue":"4","key":"pone.0353630.ref009","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1017\/S0029665118000186","article-title":"Barriers to cancer nutrition therapy: excess catabolism of muscle and adipose tissues induced by tumour products and chemotherapy","volume":"77","author":"DL Schiessel","year":"2018","journal-title":"Proc Nutr Soc"},{"issue":"12","key":"pone.0353630.ref010","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1200\/JCO.2015.63.6043","article-title":"Loss of muscle mass during chemotherapy is predictive for poor survival of patients with metastatic colorectal cancer","volume":"34","author":"S Blauwhoff-Buskermolen","year":"2016","journal-title":"J Clin Oncol"},{"issue":"6","key":"pone.0353630.ref011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129742","article-title":"Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer","volume":"10","author":"Y Miyamoto","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"pone.0353630.ref012","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/jcsm.12562","article-title":"The association between changes in muscle mass and quality of life in patients with metastatic colorectal cancer","volume":"11","author":"JWG Derksen","year":"2020","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"pone.0353630.ref013","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12885-017-3066-2","article-title":"An increase in physical activity after colorectal cancer surgery is associated with improved recovery of physical functioning: a prospective cohort study","volume":"17","author":"M van Zutphen","year":"2017","journal-title":"BMC Cancer"},{"issue":"8","key":"pone.0353630.ref014","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.molmed.2018.06.002","article-title":"Exercise training as therapy for cancer-induced cardiac cachexia","volume":"24","author":"JMM Antunes","year":"2018","journal-title":"Trends Mol Med"},{"issue":"1","key":"pone.0353630.ref015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"J Arends","year":"2017","journal-title":"Clin Nutr"},{"issue":"11","key":"pone.0353630.ref016","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise guidelines for cancer survivors","volume":"51","author":"KL Campbell","year":"2019","journal-title":"Medicine Science in Sports & Exercise"},{"issue":"2","key":"pone.0353630.ref017","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10549-014-3162-9","article-title":"Safety and efficacy of progressive resistance training in breast cancer: a systematic review and meta-analysis","volume":"148","author":"BS Cheema","year":"2014","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"pone.0353630.ref018","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/annonc\/mdt551","article-title":"Muscle dysfunction in cancer patients","volume":"25","author":"JF Christensen","year":"2014","journal-title":"Ann Oncol"},{"key":"pone.0353630.ref019","article-title":"Exercise-based interventions to counteract skeletal muscle mass loss in people with cancer: can we overcome the odds?","author":"KA Bland","year":"2022","journal-title":"Sports Medicine"},{"issue":"12","key":"pone.0353630.ref020","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1007\/s40279-021-01542-6","article-title":"The effect of resistance training on body composition during and after cancer treatment: a systematic review and meta-analysis","volume":"51","author":"B Clifford","year":"2021","journal-title":"Sports Med"},{"issue":"2","key":"pone.0353630.ref021","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1249\/MSS.0b013e3181eb6265","article-title":"Influence of resistance exercise on lean body mass in aging adults: a meta-analysis","volume":"43","author":"MD Peterson","year":"2011","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"pone.0353630.ref022","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jcsm.12268","article-title":"Pitfalls in the measurement of muscle mass: a need for a reference standard","volume":"9","author":"F Buckinx","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"pone.0353630.ref023","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3389\/fphys.2019.00843","article-title":"Supervised physical training enhances muscle strength but not muscle mass in prostate cancer patients undergoing androgen deprivation therapy: a systematic review and meta-analysis","volume":"10","author":"Z Chen","year":"2019","journal-title":"Front Physiol"},{"key":"pone.0353630.ref024","unstructured":"Resistance training and dietary supplements as intervention for regaining muscle mass following radiotherapy in head and neck cancer patients. https:\/\/ClinicalTrials.gov\/show\/NCT01025518"},{"issue":"4","key":"pone.0353630.ref025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","article-title":"Cancer cachexia, mechanism and treatment","volume":"7","author":"T Aoyagi","year":"2015","journal-title":"World J Gastrointest Oncol"},{"key":"pone.0353630.ref026","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.critrevonc.2018.11.003","article-title":"The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer","volume":"133","author":"CM Fairman","year":"2019","journal-title":"Crit Rev Oncol Hematol"},{"issue":"2","key":"pone.0353630.ref027","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12603-009-0124-8","article-title":"The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men","volume":"14","author":"MG Bemben","year":"2010","journal-title":"J Nutr Health Aging"},{"key":"pone.0353630.ref028","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1550-2783-4-6","article-title":"International Society of Sports Nutrition position stand: creatine supplementation and exercise","volume":"4","author":"TW Buford","year":"2007","journal-title":"J Int Soc Sports Nutr"},{"issue":"2","key":"pone.0353630.ref029","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00421-007-0580-y","article-title":"Creatine supplementation improves muscular performance in older women","volume":"102","author":"LA Gotshalk","year":"2008","journal-title":"Eur J Appl Physiol"},{"issue":"3","key":"pone.0353630.ref030","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00005768-200203000-00023","article-title":"Creatine supplementation improves muscular performance in older men","volume":"34","author":"LA Gotshalk","year":"2002","journal-title":"Med Sci Sports Exerc"},{"key":"pone.0353630.ref031","article-title":"Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis","volume":"266","author":"PL Greenhaff","year":"1994","journal-title":"Am J Physiol"},{"issue":"1","key":"pone.0353630.ref032","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00726-009-0263-6","article-title":"Exploring the therapeutic role of creatine supplementation","volume":"38","author":"B Gualano","year":"2010","journal-title":"Amino Acids"},{"issue":"9","key":"pone.0353630.ref033","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3390\/nu15092116","article-title":"The effects of creatine supplementation combined with resistance training on regional measures of muscle hypertrophy: a systematic review with meta-analysis","volume":"15","author":"R Burke","year":"2023","journal-title":"Nutrients"},{"issue":"6","key":"pone.0353630.ref034","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/nu17061081","article-title":"The effect of creatine supplementation on lean body mass with and without resistance training","volume":"17","author":"I Desai","year":"2025","journal-title":"Nutrients"},{"issue":"6","key":"pone.0353630.ref035","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3390\/nu13061912","article-title":"Meta-analysis examining the importance of creatine ingestion strategies on lean tissue mass and strength in older adults","volume":"13","author":"SC Forbes","year":"2021","journal-title":"Nutrients"},{"issue":"3","key":"pone.0353630.ref036","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3390\/nu13030745","article-title":"Current evidence and possible future applications of creatine supplementation for older adults","volume":"13","author":"DG Candow","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"pone.0353630.ref037","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s40279-016-0571-4","article-title":"Creatine supplementation and upper limb strength performance: a systematic review and meta-analysis","volume":"47","author":"C Lanhers","year":"2017","journal-title":"Sports Med"},{"key":"pone.0353630.ref038","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12970-017-0173-z","article-title":"International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine","volume":"14","author":"RB Kreider","year":"2017","journal-title":"J Int Soc Sports Nutr"},{"issue":"4","key":"pone.0353630.ref039","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"issue":"2","key":"pone.0353630.ref040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.14283\/jfa.2019.10","article-title":"Economic impact of hospitalizations in US adults with sarcopenia","volume":"8","author":"S Goates","year":"2019","journal-title":"J Frailty Aging"},{"issue":"2","key":"pone.0353630.ref041","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-201X.1998.00427.x","article-title":"Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults","volume":"164","author":"S Bermon","year":"1998","journal-title":"Acta Physiol Scand"},{"key":"pone.0353630.ref042","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/OAJSM.S123529","article-title":"Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis","volume":"8","author":"PD Chilibeck","year":"2017","journal-title":"Open Access J Sports Med"},{"issue":"6","key":"pone.0353630.ref043","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1249\/MSS.0000000000000220","article-title":"Creatine supplementation during resistance training in older adults-a meta-analysis","volume":"46","author":"MC Devries","year":"2014","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"pone.0353630.ref044","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jsams.2024.09.002","article-title":"Creatine supplementation does not add to resistance training effects in prostate cancer patients under androgen deprivation therapy: a double-blind randomized trial","volume":"28","author":"CM Fairman","year":"2025","journal-title":"J Sci Med Sport"},{"issue":"2","key":"pone.0353630.ref045","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/0284186X.2012.741325","article-title":"Feasibility and efficacy of progressive resistance training and dietary supplements in radiotherapy treated head and neck cancer patients--the DAHANCA 25A study","volume":"52","author":"S L\u00f8nbro","year":"2013","journal-title":"Acta Oncol"},{"key":"pone.0353630.ref046","article-title":"The effect of resistance training on body composition in cancer survivors during treatment and throughout survivorship: a systematic review and meta-analysis","author":"B Clifford","year":"2021","journal-title":"Sports Med"},{"key":"pone.0353630.ref047","unstructured":"NIH stage model for behavioral intervention development. Accessed 2022 February 8. https:\/\/www.nia.nih.gov\/research\/dbsr\/nih-stage-model-behavioral-intervention-development"},{"key":"pone.0353630.ref048","unstructured":"Health NNC f C a I. Pilot studies: common uses and misuses. https:\/\/www.nccih.nih.gov\/grants\/pilot-studies-common-uses-and-misuses"},{"issue":"5","key":"pone.0353630.ref049","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jcsm.12483","article-title":"Sarcopenia: a time for action. An SCWD position paper","volume":"10","author":"J Bauer","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"28","key":"pone.0353630.ref050","doi-asserted-by":"crossref","first-page":"43442","DOI":"10.18632\/oncotarget.9779","article-title":"Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1\/2 and p38 MAPKs","volume":"7","author":"R Barreto","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"pone.0353630.ref051","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106489","article-title":"Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle","volume":"9","author":"TP Braun","year":"2014","journal-title":"PLoS One"},{"key":"pone.0353630.ref052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2018.07.010","article-title":"Platinum-induced muscle wasting in cancer chemotherapy: Mechanisms and potential targets for therapeutic intervention","volume":"208","author":"A Moreira-Pais","year":"2018","journal-title":"Life Sci"},{"key":"pone.0353630.ref053","article-title":"Consensus on Exercise Reporting Template (CERT): explanation and elaboration statement","author":"SC Slade","year":"2016","journal-title":"Br J Sports Med"},{"key":"pone.0353630.ref054","doi-asserted-by":"crossref","first-page":"1418640","DOI":"10.3389\/fspor.2024.1418640","article-title":"A practical framework for the design of resistance exercise interventions in oncology research settings-a narrative review","volume":"6","author":"CM Fairman","year":"2024","journal-title":"Front Sports Act Living"},{"key":"pone.0353630.ref055","article-title":"Feasibility and usefulness of repetitions-in-reserve scales for selecting exercise intensity: a scoping review","author":"V Bastos","year":"2024","journal-title":"Perceptual and Motor Skills"},{"issue":"9","key":"pone.0353630.ref056","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1519\/JSC.0000000000003164","article-title":"Autoregulation by \u201cRepetitions in Reserve\u201d leads to greater improvements in strength over a 12-week training program than fixed loading","volume":"35","author":"T Graham","year":"2021","journal-title":"J Strength Cond Res"},{"issue":"4","key":"pone.0353630.ref057","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1519\/SSC.0000000000000218","article-title":"Application of the repetitions in reserve-based rating of perceived exertion scale for resistance training","volume":"38","author":"ER Helms","year":"2016","journal-title":"Strength Cond J"},{"key":"pone.0353630.ref058","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2478\/hukin-2020-0011","article-title":"Methods for Regulating and Monitoring Resistance Training","volume":"74","author":"ER Helms","year":"2020","journal-title":"J Hum Kinet"},{"issue":"10","key":"pone.0353630.ref059","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1519\/JSC.0000000000003952","article-title":"Repetitions in Reserve Is a Reliable Tool for Prescribing Resistance Training Load","volume":"36","author":"S Lovegrove","year":"2022","journal-title":"J Strength Cond Res"},{"key":"pone.0353630.ref060","doi-asserted-by":"crossref","DOI":"10.1519\/JSC.0000000000002995","article-title":"Proximity to failure and total repetitions performed in a set influences accuracy of intraset repetitions in reserve-based rating of perceived exertion","volume":"35","author":"MC Zourdos","year":"2021","journal-title":"J Strength Cond Res"},{"issue":"1","key":"pone.0353630.ref061","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s40814-023-01405-z","article-title":"Hybrid delivery of cluster-set resistance training for individuals previously treated for lung cancer: the results of a single-arm feasibility trial","volume":"9","author":"CM Fairman","year":"2023","journal-title":"Pilot Feasibility Stud"},{"key":"pone.0353630.ref062","doi-asserted-by":"crossref","first-page":"86","DOI":"10.12688\/hrbopenres.13185.2","article-title":"ReStOre@home: feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol","volume":"3","author":"L O\u2019Neill","year":"2021","journal-title":"HRB Open Res"},{"issue":"1","key":"pone.0353630.ref063","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1186\/s12913-024-11797-0","article-title":"Planning and evaluating an integrated clinical exercise oncology service: an exploratory mixed-methods study","volume":"24","author":"CM Fairman","year":"2024","journal-title":"BMC Health Serv Res"},{"issue":"5","key":"pone.0353630.ref064","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/abm\/kax002","article-title":"Effects of a group-mediated exercise and dietary intervention in the treatment of prostate cancer patients undergoing androgen deprivation therapy: results from the IDEA-P trial","volume":"52","author":"BC Focht","year":"2018","journal-title":"Ann Behav Med"},{"issue":"2","key":"pone.0353630.ref065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1249\/MSS.0000000000002127","article-title":"Reporting of resistance training dose, adherence, and tolerance in exercise oncology","volume":"52","author":"CM Fairman","year":"2020","journal-title":"Med Sci Sports Exerc"},{"issue":"9","key":"pone.0353630.ref066","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1249\/MSS.0b013e318176b310","article-title":"Low-dose creatine combined with protein during resistance training in older men","volume":"40","author":"DG Candow","year":"2008","journal-title":"Med Sci Sports Exerc"},{"issue":"9","key":"pone.0353630.ref067","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-030080","article-title":"Examining the effects of creatine supplementation in augmenting adaptations to resistance training in patients with prostate cancer undergoing androgen deprivation therapy: a randomised, double-blind, placebo-controlled trial","volume":"9","author":"CM Fairman","year":"2019","journal-title":"BMJ Open"},{"issue":"6","key":"pone.0353630.ref068","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.orcp.2020.10.005","article-title":"Precision of the hologic horizon a dual energy x-ray absorptiometry in the assessment of body composition","volume":"14","author":"YM Cheung","year":"2020","journal-title":"Obes Res Clin Pract"},{"issue":"2","key":"pone.0353630.ref069","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/1754-9485.12646","article-title":"Short term in vivo precision of whole body composition measurements on the Horizon A densitometer","volume":"62","author":"M Nowitz","year":"2018","journal-title":"J Med Imaging Radiat Oncol"},{"issue":"12","key":"pone.0353630.ref070","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1519\/JSC.0000000000004143","article-title":"One repetition maximum test-retest reliability and safety using keiser pneumatic resistance training machines with older women","volume":"35","author":"MA Infante","year":"2021","journal-title":"J Strength Cond Res"},{"issue":"1","key":"pone.0353630.ref071","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40798-020-00260-z","article-title":"Test-Retest Reliability of the One-Repetition Maximum (1RM) Strength Assessment: a Systematic Review","volume":"6","author":"J Grgic","year":"2020","journal-title":"Sports Med Open"},{"issue":"6","key":"pone.0353630.ref072","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0270132","article-title":"Validity and reliability of handgrip dynamometry in older adults: a comparison of two widely used dynamometers","volume":"17","author":"MJ Benton","year":"2022","journal-title":"PLoS One"},{"issue":"12","key":"pone.0353630.ref073","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/nu16121824","article-title":"A cross-sectional validation study of camry eh101 versus jamar plus handheld dynamometers in colorectal cancer patients and their correlations with bioelectrical impedance and nutritional status","volume":"16","author":"A Jim\u00e9nez-S\u00e1nchez","year":"2024","journal-title":"Nutrients"},{"key":"pone.0353630.ref074","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fmed.2020.00052","article-title":"Normative values for the short physical performance battery (sppb) and their association with anthropometric variables in older colombian adults. the SABE study, 2015","volume":"7","author":"R Ram\u00edrez-V\u00e9lez","year":"2020","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"pone.0353630.ref075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12877-017-0514-4","article-title":"\u201cReliability of the Norwegian version of the short physical performance battery in older people with and without dementia\u201d","volume":"17","author":"CF Olsen","year":"2017","journal-title":"BMC Geriatr"},{"issue":"3","key":"pone.0353630.ref076","doi-asserted-by":"crossref","first-page":"165","DOI":"10.25100\/cm.v44i3.1181","article-title":"Validity and reliability of the Short Physical Performance Battery (SPPB): a pilot study on mobility in the Colombian Andes","volume":"44","author":"JF G\u00f3mez","year":"2013","journal-title":"Colomb Med (Cali)"},{"issue":"8","key":"pone.0353630.ref077","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"CL Craig","year":"2003","journal-title":"Med Sci Sports Exerc"},{"issue":"10","key":"pone.0353630.ref078","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/annonc\/mdq721","article-title":"Choosing between the EORTC QLQ-C30 and FACT-G for measuring health-related quality of life in cancer clinical research: issues, evidence and recommendations","volume":"22","author":"T Luckett","year":"2011","journal-title":"Ann Oncol"},{"issue":"5","key":"pone.0353630.ref079","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1200\/JCO.1995.13.5.1249","article-title":"Test\/retest study of the European organization for research and treatment of cancer core quality-of-life questionnaire","volume":"13","author":"MJ Hjermstad","year":"1995","journal-title":"J Clin Oncol"},{"issue":"5","key":"pone.0353630.ref080","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"NK Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"pone.0353630.ref081","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1023\/A:1026429831234","article-title":"Modification of the EORTC QLQ-C30 (version 2.0) based on content validity and reliability testing in large samples of patients with cancer. The study group on quality of life of the EORTC and the symptom control and quality of life committees of the NCI of Canada Clinical Trials Group","volume":"6","author":"D Osoba","year":"1997","journal-title":"Qual Life Res"},{"issue":"2","key":"pone.0353630.ref082","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/jcsm.12149","article-title":"Validation of the SarQoL\u00ae, a specific health-related quality of life questionnaire for Sarcopenia","volume":"8","author":"C Beaudart","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"pone.0353630.ref083","first-page":"271","article-title":"English translation and validation of the SarQoL\u00ae, a quality of life questionnaire specific for sarcopenia","volume":"46","author":"C Beaudart","year":"2017","journal-title":"Age Ageing"},{"issue":"4","key":"pone.0353630.ref084","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pst.185","article-title":"Sample size of 12 per group rule of thumb for a pilot study","volume":"4","author":"SA Julious","year":"2005","journal-title":"Pharmaceutical Statistics"},{"issue":"7321","key":"pone.0353630.ref085","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/bmj.323.7321.1123","article-title":"Statistics notes: analysing controlled trials with baseline and follow up measurements","volume":"323","author":"AJ Vickers","year":"2001","journal-title":"BMJ"},{"issue":"21","key":"pone.0353630.ref086","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1001\/jama.2022.21506","article-title":"Adjustment for baseline characteristics in randomized clinical trials","volume":"328","author":"MJ Holmberg","year":"2022","journal-title":"JAMA"},{"key":"pone.0353630.ref087","doi-asserted-by":"crossref","first-page":"106242","DOI":"10.1016\/j.cct.2020.106242","article-title":"Recruitment strategies and design considerations in a trial of resistance training to prevent dose-limiting toxicities in colon cancer patients undergoing chemotherapy","volume":"101","author":"BJ Caan","year":"2021","journal-title":"Contemp Clin Trials"},{"issue":"4","key":"pone.0353630.ref088","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s11764-023-01363-8","article-title":"Recruitment rates and strategies in exercise trials in cancer survivorship: a systematic review","volume":"18","author":"SA Reynolds","year":"2024","journal-title":"J Cancer Surviv"},{"key":"pone.0353630.ref089","doi-asserted-by":"crossref","DOI":"10.1016\/S1047-2797(00)00197-6","article-title":"Recruitment and retention of minority women in cancer screening, prevention, and treatment trials","volume":"10","author":"DR Brown","year":"2000","journal-title":"Ann Epidemiol"},{"issue":"6","key":"pone.0353630.ref090","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s40615-016-0332-y","article-title":"Barriers and strategies for recruitment of racial and ethnic minorities: perspectives from neurological clinical research coordinators","volume":"4","author":"SJ Haley","year":"2017","journal-title":"J Racial Ethn Health Disparities"},{"issue":"2","key":"pone.0353630.ref091","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/0260106020975247","article-title":"Effect of 12 months of creatine supplementation and whole-body resistance training on measures of bone, muscle and strength in older males","volume":"27","author":"DG Candow","year":"2021","journal-title":"Nutr Health"},{"key":"pone.0353630.ref092","author":"D Patel","year":"2019"},{"issue":"4","key":"pone.0353630.ref093","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/jcsm.12094","article-title":"Impact of creatine supplementation in combination with resistance training on lean mass in the elderly","volume":"7","author":"CL Pinto","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"pone.0353630.ref094","first-page":"126","article-title":"Resistance training and co-supplementation with creatine and protein in older subjects with frailty","volume":"5","author":"J Collins","year":"2016","journal-title":"J Frailty Aging"},{"issue":"8","key":"pone.0353630.ref095","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1249\/MSS.0000000000000571","article-title":"Effects of creatine and resistance training on bone health in postmenopausal women","volume":"47","author":"PD Chilibeck","year":"2015","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"pone.0353630.ref096","article-title":"Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies","volume":"7","author":"KNL Avery","year":"2017","journal-title":"BMJ Open"},{"issue":"1","key":"pone.0353630.ref097","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s13063-019-3578-y","article-title":"Progression criteria in trials with an internal pilot: an audit of publicly funded randomised controlled trials","volume":"20","author":"E Herbert","year":"2019","journal-title":"Trials"},{"issue":"1","key":"pone.0353630.ref098","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40814-023-01291-5","article-title":"Recommendations for progression criteria during external randomised pilot trial design, conduct, analysis and reporting","volume":"9","author":"K Mellor","year":"2023","journal-title":"Pilot Feasibility Stud"},{"issue":"8","key":"pone.0353630.ref099","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/bjsports-2016-096537","article-title":"Resistance training interventions across the cancer control continuum: a systematic review of the implementation of resistance training principles","volume":"51","author":"CM Fairman","year":"2017","journal-title":"Br J Sports Med"},{"issue":"9","key":"pone.0353630.ref100","first-page":"2953","article-title":"Effects of resistance exercise in prostate cancer patients: a meta-analysis","volume":"25","author":"M Keilani","year":"2017","journal-title":"Support Care Cancer"},{"issue":"7","key":"pone.0353630.ref101","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1249\/MSS.0000000000001250","article-title":"Effects of resistance training and protein supplementation in breast cancer survivors","volume":"49","author":"TA Madzima","year":"2017","journal-title":"Med Sci Sports Exerc"},{"issue":"7","key":"pone.0353630.ref102","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.3390\/ijerph19073820","article-title":"Does androgen deprivation for prostate cancer affect normal adaptation to resistance exercise?","volume":"19","author":"TS Nilsen","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"10","key":"pone.0353630.ref103","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.3109\/0284186X.2015.1037008","article-title":"Effects of strength training on body composition, physical functioning, and quality of life in prostate cancer patients during androgen deprivation therapy","volume":"54","author":"TS Nilsen","year":"2015","journal-title":"Acta Oncol"},{"issue":"3","key":"pone.0353630.ref104","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11764-016-0592-x","article-title":"Evaluation of resistance training to improve muscular strength and body composition in cancer patients undergoing neoadjuvant and adjuvant therapy: a meta-analysis","volume":"11","author":"CS Padilha","year":"2017","journal-title":"J Cancer Surviv"},{"key":"pone.0353630.ref105","article-title":"Variables influencing the effectiveness of creatine supplementation as a therapeutic intervention for sarcopenia","author":"DG Candow","year":"2019","journal-title":"Frontiers in Nutrition"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0353630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:35:44Z","timestamp":1784136944000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0353630"}},"subtitle":[],"editor":[{"given":"Diego A.","family":"Bonilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":105,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0353630","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]}}}