{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:05:00Z","timestamp":1784657100061,"version":"3.55.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Maternal alcohol use is a modifiable, yet significant public health concern, causing fetal alcohol syndrome and neurodevelopmental disorders. Research has predominantly focused on the neurodevelopmental consequences of maternal alcohol consumption, but growing evidence suggests that these effects may extend to the developing immune system, potentially increasing the risk of allergic and inflammatory conditions such as atopic dermatitis in offspring, which remains underexplored. This scoping review aims to map the available literature on the association between maternal alcohol exposure (preconception and pregnancy) and atopic dermatitis in offspring, including exposure patterns, outcome measures, and hypothesized biological mechanisms. The protocol follows Joanna Briggs Institute methodology with PEO framework (Population: offspring, Exposure: maternal alcohol use, Outcome: atopic dermatitis), and has been registered prospectively on the Open Science Framework (DOI:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.17605\/OSF.IO\/EWGPB\" xlink:type=\"simple\">10.17605\/OSF.IO\/EWGPB<\/jats:ext-link>\n                    ). A comprehensive search of electronic databases (PubMed, Scopus, Embase, CINAHL, Web of Science) and grey literature sources will be conducted from inception through the final search date. Two independent reviewers will screen titles, abstracts and full texts, with disagreements resolved by consensus or third-reviewer arbitration. Peer-reviewed original research articles in English reporting maternal alcohol use and diagnosed atopic dermatitis in offspring will be included. Data extraction will comprise study characteristics, exposure timing and measurement, outcome diagnostic criteria and age of assessment, key findings, and reported biological mechanisms. The preliminary findings will be validated through consultation with clinical stakeholders, including experts in allergy medicine, paediatricians, dermatologists, psychiatrists and obstetricians, to maximise the review\u2019s relevance and to identify practical implications for antenatal care and paediatric dermatology. Results will be presented through narrative synthesis, following PRISMA-ScR guidelines, to identify evidence gaps and inform future research and policy.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0354140","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:30:17Z","timestamp":1784655017000},"page":"e0354140","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal alcohol exposure and atopic dermatitis in offspring: A scoping review protocol"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-0911","authenticated-orcid":true,"given":"Priyanka Renita","family":"D\u2019Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Princia Rolita","family":"D\u2019Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"6","key":"pone.0354140.ref001","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/alcalc\/ags089","article-title":"Maternal alcohol use during pregnancy, birth weight and early behavioral outcomes","volume":"47","author":"J-H Chen","year":"2012","journal-title":"Alcohol Alcohol"},{"key":"pone.0354140.ref002","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/AOG.0b013e31822c9906","article-title":"Committee opinion no. 496: At-risk drinking and alcohol dependence: obstetric and gynecologic implications","volume":"118","author":"American College of Obstetricians and Gynecologists","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"10","key":"pone.0354140.ref003","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1001\/jamapediatrics.2017.1919","article-title":"Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis","volume":"171","author":"S Lange","year":"2017","journal-title":"JAMA Pediatr"},{"key":"pone.0354140.ref004","doi-asserted-by":"crossref","DOI":"10.1111\/j.1530-0277.1998.tb04387.x","article-title":"Alcohol and fetal damage","volume":"22","author":"P Allebeck","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"pone.0354140.ref005","first-page":"710","article-title":"Alcohol intake in pregnancy increases the child\u2019s risk of atopic dermatitis: The COPSAC prospective birth cohort study of a high risk population","volume":"130","author":"CG Carson","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"pone.0354140.ref006","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/j.1365-2222.2004.02101.x","article-title":"Alcohol during pregnancy and atopic dermatitis in the offspring","volume":"34","author":"A Linneberg","year":"2004","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"pone.0354140.ref007","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/acer.13048","article-title":"Alcohol Intake During Pregnancy and Offspring\u2019s Atopic Eczema Risk","volume":"40","author":"K Wada","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"pone.0354140.ref008","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.iac.2010.06.003","article-title":"Epidemiology of atopic dermatitis and atopic march in children","volume":"30","author":"JM Spergel","year":"2010","journal-title":"Immunol Allergy Clin North Am"},{"issue":"1","key":"pone.0354140.ref009","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0190-9622(94)70004-4","article-title":"The prevalence of childhood atopic eczema in a general population","volume":"30","author":"J Kay","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"pone.0354140.ref010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2003.09.033","article-title":"Atopic dermatitis and the atopic march","volume":"112","author":"JM Spergel","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"pone.0354140.ref011","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2133.1994.tb08532.x","article-title":"The UK Working Party\u2019s diagnostic criteria for atopic dermatitis. 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