{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:02:14Z","timestamp":1785261734486,"version":"3.55.0"},"reference-count":97,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente 2025"],"award-info":[{"award-number":["Ricerca Corrente 2025"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy","award":["5x1000 funds 2021 for biomedical research"],"award-info":[{"award-number":["5x1000 funds 2021 for biomedical research"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Numerous neurocognitive and behavioral deficits in adolescents with acquired brain injury have been associated with impairments in executive functions. Nevertheless, many adolescents do not receive targeted rehabilitation. One of the most validated interventions addressing executive dysfunction in this population is the web-based Teen Online Problem Solving (TOPS) program, developed in the United States in the early 2000s. This study aimed to evaluate the feasibility of the Italian version of TOPS (I-TOPS) in its first implementation in Italy, compared with an active control wellness intervention in adolescents aged 11\u201319 years. Data on the feasibility of both the training and the study design and procedures are reported from the randomized controlled trial conducted to assess feasibility prior to a full evaluation of efficacy. Forty-two adolescents participated, 21 allocated to I-TOPS and 21 to the wellness intervention. Overall willingness to participate in the study, assessed before randomization across the full sample, was moderate (61.73%). The I-TOPS group, but not the wellness group, demonstrated adequate training adherence, training satisfaction and participation rates. No technological issues hindering program completion, accessibility difficulties with the web-based platform or significant loss to follow-up among participants who completed the training were reported in either group. However, challenges in collecting outcome measures on parent functioning due to refusal were observed in both groups. Adherence to the planned assessment timeline was satisfactory but not fully met. In sum, the findings suggest that I-TOPS represents a feasible approach that is subjectively perceived as useful and engaging by adolescents with acquired brain injury and their families. Nevertheless, the moderate acceptance rate in the study and the potential stigma associated with reporting mental health concerns among some parents may limit the generalizability of the findings. These factors should be taken into account when planning efficacy studies. This study was registered at ClinicalTrials.gov (NCT05169788).<\/jats:p>","DOI":"10.1371\/journal.pone.0354280","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:42:56Z","timestamp":1785260576000},"page":"e0354280","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of the Italian version of the Teen Online Problem Solving Program (I-TOPS) in a sample of adolescents with acquired brain injury: Results from a randomized controlled trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-3182","authenticated-orcid":true,"given":"Claudia","family":"Corti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Papini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Strazzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Borgatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Romaniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldina","family":"Poggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio A.","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Urgesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Jansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari L.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bardoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"8","key":"pone.0354280.ref001","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1080\/09297049.2019.1589442","article-title":"Parenting and the dysregulation profile predict executive functioning in children with acquired brain injury","volume":"25","author":"C Chavez-Arana","year":"2019","journal-title":"Child Neuropsychol"},{"issue":"7","key":"pone.0354280.ref002","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3390\/brainsci13071000","article-title":"Long-Term Vocational Outcome at 15 Years from Severe Traumatic and Non-Traumatic Brain Injury in Pediatric Age","volume":"13","author":"S Strazzer","year":"2023","journal-title":"Brain Sci"},{"issue":"20","key":"pone.0354280.ref003","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1089\/neu.2018.6308","article-title":"Unraveling the Association between Pediatric Traumatic Brain Injury and Social Dysfunction: The Mediating Role of Self-Regulation","volume":"36","author":"NP Ryan","year":"2019","journal-title":"J Neurotrauma"},{"issue":"2","key":"pone.0354280.ref004","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1089\/neu.2017.5265","article-title":"Psychosocial and Executive Function Recovery Trajectories One Year after Pediatric Traumatic Brain Injury: The Influence of Age and Injury Severity","volume":"35","author":"HT Keenan","year":"2018","journal-title":"J Neurotrauma"},{"issue":"6","key":"pone.0354280.ref005","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/HTR.0000000000000001","article-title":"Substance abuse and criminal activities following traumatic brain injury in childhood, adolescence, and early adulthood","volume":"29","author":"A McKinlay","year":"2014","journal-title":"J Head Trauma Rehabil"},{"issue":"10","key":"pone.0354280.ref006","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1080\/02699052.2019.1641621","article-title":"Pediatric traumatic brain injury and antisocial behavior: are they linked? A systematic review","volume":"33","author":"G Bellesi","year":"2019","journal-title":"Brain Inj"},{"issue":"2","key":"pone.0354280.ref007","article-title":"Long-Term Outcomes of Pediatric Traumatic Brain Injury Following Inpatient Rehabilitation","volume":"39","author":"TC Horn","year":"2024","journal-title":"J Head Trauma Rehabil"},{"key":"pone.0354280.ref008","doi-asserted-by":"crossref","first-page":"899","DOI":"10.15585\/mmwr.mm7233a5","article-title":"Percentage of children and adolescents aged \u226417 years who had ever received a diagnosis of concussion or brain injury, by sex and age group \u2014 National Health Interview Survey, United States, 2022","volume":"72","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"pone.0354280.ref009","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0883073814544363","article-title":"The Epidemiology of Traumatic Brain Injury in Children and Youths: A Review of Research Since 1990","volume":"31","author":"DJ Thurman","year":"2016","journal-title":"J Child Neurol"},{"key":"pone.0354280.ref010","unstructured":"Head injury: assessment and early management. National Institute for Health and Care Excellence (NICE). 2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK592586\/"},{"issue":"5","key":"pone.0354280.ref011","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/00004583-200105000-00017","article-title":"Lifetime and novel psychiatric disorders after pediatric traumatic brain injury","volume":"40","author":"DR Bloom","year":"2001","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"5","key":"pone.0354280.ref012","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1001\/jamapediatrics.2017.5746","article-title":"Secondary Attention-Deficit\/Hyperactivity Disorder in Children and Adolescents 5 to 10 Years After Traumatic Brain Injury","volume":"172","author":"ME Narad","year":"2018","journal-title":"JAMA Pediatr"},{"issue":"11","key":"pone.0354280.ref013","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1001\/jamapediatrics.2024.3452","article-title":"Mild Traumatic Brain Injury and Criminal Charges and Convictions in Mid and Late Adolescence","volume":"178","author":"EH Blaab\u00e6k","year":"2024","journal-title":"JAMA Pediatr"},{"issue":"12","key":"pone.0354280.ref014","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1080\/02699052.2017.1341999","article-title":"The experiences of parenting a child with an acquired brain injury: A meta-synthesis of the qualitative literature","volume":"31","author":"E Tyerman","year":"2017","journal-title":"Brain Inj"},{"issue":"1","key":"pone.0354280.ref015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0269905021000010096","article-title":"Parental stress and burden following traumatic brain injury amongst children and adolescents","volume":"17","author":"CA Hawley","year":"2003","journal-title":"Brain Inj"},{"issue":"8","key":"pone.0354280.ref016","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-029349","article-title":"Clinical and cost-effectiveness of teen online problem-solving for adolescents who have survived an acquired brain injury in the UK: protocol for a randomised, controlled feasibility study (TOPS-UK)","volume":"9","author":"J Limond","year":"2019","journal-title":"BMJ Open"},{"issue":"2","key":"pone.0354280.ref017","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3758\/BF03195572","article-title":"A web-based family problem-solving intervention for families of children with traumatic brain injury","volume":"36","author":"SL Wade","year":"2004","journal-title":"Behav Res Methods Instrum Comput"},{"issue":"4","key":"pone.0354280.ref018","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2005-1892","article-title":"Health care utilization and needs after pediatric traumatic brain injury","volume":"117","author":"BS Slomine","year":"2006","journal-title":"Pediatrics"},{"issue":"3","key":"pone.0354280.ref019","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1037\/0090-5550.51.3.179","article-title":"The efficacy of an online cognitive-behavioral family intervention in improving child behavior and social competence following pediatric brain injury","volume":"51","author":"SL Wade","year":"2006","journal-title":"Rehabil Psychol"},{"issue":"5","key":"pone.0354280.ref020","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/apa.16693","article-title":"Almost half of children and adolescents had unmet need 6\u2009months after their traumatic brain injury","volume":"112","author":"HM Dahl","year":"2023","journal-title":"Acta Paediatr"},{"key":"pone.0354280.ref021","unstructured":"All-Party Parliamentary Group on Acquired Brain Injury. Acquired brain injury and neurorehabilitation: time for change. 2018. https:\/\/ukabif.org.uk\/page\/time-for-change"},{"issue":"22","key":"pone.0354280.ref022","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1089\/neu.2014.3422","article-title":"Executive functions and theory of mind as predictors of social adjustment in childhood traumatic brain injury","volume":"31","author":"KE Robinson","year":"2014","journal-title":"J Neurotrauma"},{"issue":"6","key":"pone.0354280.ref023","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1080\/09602011.2013.835739","article-title":"Executive function, self-regulation and attribution in acquired brain injury: A scoping review","volume":"23","author":"AW Hunt","year":"2013","journal-title":"Neuropsychol Rehabil"},{"key":"pone.0354280.ref024","doi-asserted-by":"crossref","first-page":"1160210","DOI":"10.3389\/fpsyg.2023.1160210","article-title":"Comprehensive assessment of executive functioning following childhood severe traumatic brain injury: clinical utility of the child executive functions battery","volume":"14","author":"M Chevignard","year":"2023","journal-title":"Front Psychol"},{"issue":"9","key":"pone.0354280.ref025","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/jcpp.13385","article-title":"Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury","volume":"62","author":"NP Ryan","year":"2021","journal-title":"J Child Psychol Psychiatry"},{"issue":"3","key":"pone.0354280.ref026","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1108\/SCN-08-2013-0030","article-title":"Age at injury, emotional problems and executive functioning in understanding disrupted social relationships following childhood acquired brain injury","volume":"5","author":"F Gracey","year":"2014","journal-title":"Social Care and Neurodisability"},{"issue":"4","key":"pone.0354280.ref027","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1745-9125.2011.00252.x","article-title":"Neuropsychological measures of executive function and antisocial behavior: a meta-analysis*","volume":"49","author":"JM Ogilvie","year":"2011","journal-title":"Criminology"},{"key":"pone.0354280.ref028","first-page":"23","article-title":"Developmental trajectories of executive functions across the lifespan.","volume-title":"Executive functions and the frontal lobes: a lifespan perspective","author":"CR De Luca","year":"2008"},{"issue":"1","key":"pone.0354280.ref029","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0278-2626(03)00275-6","article-title":"Development of \u201chot\u201d executive function: the children\u2019s gambling task","volume":"55","author":"A Kerr","year":"2004","journal-title":"Brain Cogn"},{"issue":"12","key":"pone.0354280.ref030","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s11920-017-0862-y","article-title":"Psychiatric Sequelae of Concussions","volume":"19","author":"DA Brent","year":"2017","journal-title":"Curr Psychiatry Rep"},{"issue":"3","key":"pone.0354280.ref031","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1037\/a0027973","article-title":"Cognitive predictors of academic achievement in young children 1 year after traumatic brain injury","volume":"26","author":"JB Fulton","year":"2012","journal-title":"Neuropsychology"},{"issue":"1","key":"pone.0354280.ref032","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/09297049.2023.2172150","article-title":"Interventions to improve executive functions in children and adolescents with acquired brain injury: a systematic review and multilevel meta-analysis","volume":"30","author":"C Chavez Arana","year":"2024","journal-title":"Child Neuropsychol"},{"issue":"4","key":"pone.0354280.ref033","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10802-020-00737-1","article-title":"Caregiver and child behavioral health service utilization following pediatric traumatic brain injury","volume":"49","author":"AP Fisher","year":"2021","journal-title":"Research on Child and Adolescent Psychopathology"},{"issue":"4","key":"pone.0354280.ref034","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/02699052.2022.2034956","article-title":"Professional stakeholders\u2019 perceptions of barriers to behavioral health care following pediatric traumatic brain injury","volume":"36","author":"AE Miley","year":"2022","journal-title":"Brain Inj"},{"issue":"9","key":"pone.0354280.ref035","doi-asserted-by":"crossref","DOI":"10.1016\/j.apmr.2016.12.013","article-title":"Auditing access to outpatient rehabilitation services for children with traumatic brain injury and public insurance in Washington State","volume":"98","author":"MM Fuentes","year":"2017","journal-title":"Arch Phys Med Rehabil"},{"issue":"5","key":"pone.0354280.ref036","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-2859","article-title":"Unmet Rehabilitation Needs After Hospitalization for Traumatic Brain Injury","volume":"141","author":"MM Fuentes","year":"2018","journal-title":"Pediatrics"},{"issue":"2","key":"pone.0354280.ref037","doi-asserted-by":"crossref","DOI":"10.1097\/HTR.0000000000000433","article-title":"Attending Follow-up Appointments After Pediatric Traumatic Brain Injury: Caregiver-Perceived Barriers and Facilitators","volume":"34","author":"K Lever","year":"2019","journal-title":"J Head Trauma Rehabil"},{"issue":"7","key":"pone.0354280.ref038","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.apmr.2013.02.021","article-title":"Initiation of physical, occupational, and speech therapy in children with traumatic brain injury","volume":"94","author":"TD Bennett","year":"2013","journal-title":"Arch Phys Med Rehabil"},{"issue":"4","key":"pone.0354280.ref039","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1037\/rep0000414","article-title":"Adapting intervention approaches to new contexts: Three case studies of international adaptation of the Teen Online Problem Solving (TOPS) program","volume":"66","author":"SL Wade","year":"2021","journal-title":"Rehabil Psychol"},{"issue":"6","key":"pone.0354280.ref040","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/DBP.0000000000000681","article-title":"Behavioral Health Service Utilization and Unmet Need After Traumatic Brain Injury in Childhood","volume":"40","author":"ME Narad","year":"2019","journal-title":"J Dev Behav Pediatr"},{"issue":"9","key":"pone.0354280.ref041","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/02699052.2019.1637542","article-title":"A scoping review of the needs of children and young people with acquired brain injuries and their families","volume":"33","author":"R Keetley","year":"2019","journal-title":"Brain Inj"},{"issue":"1","key":"pone.0354280.ref042","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11065-020-09429-5","article-title":"Effectiveness of Computerized Cognitive Training Programs (CCTP) with Game-like Features in Children with or without Neuropsychological Disorders: a Meta-Analytic Investigation","volume":"30","author":"V Oldrati","year":"2020","journal-title":"Neuropsychol Rev"},{"issue":"7","key":"pone.0354280.ref043","article-title":"Technological aids for the rehabilitation of memory and executive functioning in children and adolescents with acquired brain injury","volume":"7","author":"M Linden","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"pone.0354280.ref044","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/09602011.2019.1678490","article-title":"Evidence-based systematic review of cognitive rehabilitation, emotional, and family treatment studies for children with acquired brain injury literature: From 2006 to 2017","volume":"30","author":"L Laatsch","year":"2020","journal-title":"Neuropsychol Rehabil"},{"key":"pone.0354280.ref045","doi-asserted-by":"crossref","first-page":"1346987","DOI":"10.1155\/2019\/1346987","article-title":"Remote Technology-Based Training Programs for Children with Acquired Brain Injury: A Systematic Review and a Meta-Analytic Exploration","volume":"2019","author":"C Corti","year":"2019","journal-title":"Behav Neurol"},{"issue":"8","key":"pone.0354280.ref046","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/jpepsy\/jsy013","article-title":"A Systematic Review of Interventions for Hot and Cold Executive Functions in Children and Adolescents With Acquired Brain Injury","volume":"43","author":"C Chavez-Arana","year":"2018","journal-title":"J Pediatr Psychol"},{"issue":"2","key":"pone.0354280.ref047","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1037\/int0000215","article-title":"Telepsychotherapy With Children and Families: Lessons Gleaned From Two Decades of Translational Research","volume":"30","author":"SL Wade","year":"2020","journal-title":"J Psychother Integr"},{"issue":"2","key":"pone.0354280.ref048","doi-asserted-by":"crossref","DOI":"10.5195\/ijt.2021.6423","article-title":"Feasibility and Acceptability of a Real-Time Telerehabilitation Intervention for Children and Young Adults with Acquired Brain Injury During the COVID-19 Pandemic: An Experience Report","volume":"13","author":"MC Oprandi","year":"2021","journal-title":"Int J Telerehabil"},{"issue":"3","key":"pone.0354280.ref049","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/02699052.2024.2309252","article-title":"Further recommendations of the International Paediatric Brain Injury Society (IPBIS) for the post-acute rehabilitation of children with acquired brain injury","volume":"38","author":"MA Linden","year":"2024","journal-title":"Brain Inj"},{"key":"pone.0354280.ref050","first-page":"197","article-title":"Problem-solving therapy.","volume-title":"Handbook of cognitive behavioral therapies","author":"TJ D\u2019Zurilla","year":"2010"},{"key":"pone.0354280.ref051","first-page":"11","article-title":"Social Problem Solving: Theory and Assessment","author":"TJ D\u2019Zurilla","journal-title":"Social problem solving: Theory, research, and training. American Psychological Association"},{"key":"pone.0354280.ref052","volume-title":"Negotiating parent-adolescent conflict: A behavioral-family systems approach","author":"AF Robin","year":"1989","edition":"1"},{"issue":"1","key":"pone.0354280.ref053","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1017\/BrImp.2013.9","article-title":"Integrating Interventions after Traumatic Brain Injury: A Synergistic Approach to Neurorehabilitation","volume":"14","author":"K Dams-O\u2019Connor","year":"2013","journal-title":"Brain Impairment"},{"issue":"6","key":"pone.0354280.ref054","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1080\/02699052.2018.1458335","article-title":"Searching for effective components of cognitive rehabilitation for children and adolescents with acquired brain injury: A systematic review","volume":"32","author":"C Resch","year":"2018","journal-title":"Brain Inj"},{"issue":"3","key":"pone.0354280.ref055","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/jpepsy\/jsy087","article-title":"The Relationship of Adolescent and Parent Preferences for Treatment Modality With Satisfaction, Attrition, Adherence, and Efficacy: The Coping With Head Injury Through Problem-Solving (CHIPS) Study","volume":"44","author":"SL Wade","year":"2019","journal-title":"J Pediatr Psychol"},{"issue":"3","key":"pone.0354280.ref056","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1037\/rep0000160","article-title":"Teen online problem solving for teens with traumatic brain injury: Rationale, methods, and preliminary feasibility of a teen only intervention","volume":"62","author":"SL Wade","year":"2017","journal-title":"Rehabil Psychol"},{"key":"pone.0354280.ref057","doi-asserted-by":"crossref","first-page":"1089079","DOI":"10.3389\/fresc.2022.1089079","article-title":"Widespread clinical implementation of the teen online problem-solving program: Progress, barriers, and lessons learned","volume":"3","author":"SL Wade","year":"2023","journal-title":"Front Rehabil Sci"},{"issue":"3","key":"pone.0354280.ref058","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/HTR.0000000000000545","article-title":"Online Family Problem-Solving Therapy (F-PST) for Executive and Behavioral Dysfunction After Traumatic Brain Injury in Adolescents: A Randomized, Multicenter, Comparative Effectiveness Clinical Trial","volume":"35","author":"BG Kurowski","year":"2020","journal-title":"J Head Trauma Rehabil"},{"issue":"6","key":"pone.0354280.ref059","article-title":"A Randomized Comparative Effectiveness Trial of Family-Problem-Solving Treatment for Adolescent Brain Injury: Parent Outcomes From the Coping with Head Injury through Problem Solving (CHIPS) Study","volume":"34","author":"SL Wade","year":"2019","journal-title":"J Head Trauma Rehabil"},{"issue":"9","key":"pone.0354280.ref060","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1017\/S1355617719000778","article-title":"Recovery Trajectories of Child and Family Outcomes Following Online Family Problem-Solving Therapy for Children and Adolescents after Traumatic Brain Injury","volume":"25","author":"SL Wade","year":"2019","journal-title":"J Int Neuropsychol Soc"},{"issue":"1","key":"pone.0354280.ref061","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/s41598-020-57952-5","article-title":"Home-based cognitive training in pediatric patients with acquired brain injury: preliminary results on efficacy of a randomized clinical trial","volume":"10","author":"C Corti","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0354280.ref062","doi-asserted-by":"crossref","first-page":"14559","DOI":"10.1038\/s41598-023-41810-1","article-title":"Randomized clinical trial on the effects of a computerized cognitive training for pediatric patients with acquired brain injury or congenital malformation","volume":"13","author":"C Corti","year":"2023","journal-title":"Sci Rep"},{"key":"pone.0354280.ref063","doi-asserted-by":"crossref","first-page":"1295273","DOI":"10.3389\/fpubh.2024.1295273","article-title":"The wide world of technological telerehabilitation for pediatric neurologic and neurodevelopmental disorders - a systematic review","volume":"12","author":"B Del Lucchese","year":"2024","journal-title":"Front Public Health"},{"key":"pone.0354280.ref064","doi-asserted-by":"crossref","first-page":"563375","DOI":"10.3389\/fneur.2020.563375","article-title":"Tele-Neuro-Rehabilitation in Italy: State of the Art and Future Perspectives","volume":"11","author":"G Maresca","year":"2020","journal-title":"Front Neurol"},{"key":"pone.0354280.ref065","doi-asserted-by":"crossref","DOI":"10.2196\/64178","article-title":"Examining the Implementation of the Italian Version of the Teen Online Problem-Solving Program Coupled With Remote Psychological Support: Protocol for a Randomized Controlled Trial","volume":"14","author":"C Corti","year":"2025","journal-title":"JMIR Res Protoc"},{"issue":"6","key":"pone.0354280.ref066","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199001","article-title":"Feasibility of a home-based computerized cognitive training for pediatric patients with congenital or acquired brain damage: An explorative study","volume":"13","author":"C Corti","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"pone.0354280.ref067","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/g4h.2016.0043","article-title":"How to Train an Injured Brain? A Pilot Feasibility Study of Home-Based Computerized Cognitive Training","volume":"6","author":"H Verhelst","year":"2017","journal-title":"Games Health J"},{"issue":"23","key":"pone.0354280.ref068","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1089\/neu.2015.4358","article-title":"Computerized Working Memory Training for Children with Moderate to Severe Traumatic Brain Injury: A Double-Blind, Randomized, Placebo-Controlled Trial","volume":"33","author":"NL Phillips","year":"2016","journal-title":"J Neurotrauma"},{"issue":"5","key":"pone.0354280.ref069","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1037\/neu0000951","article-title":"Rehabilitation of Executive Function in Pediatric Traumatic Brain Injury (REPeaT): Outcomes of a pilot randomized controlled trial","volume":"38","author":"NT Sood","year":"2024","journal-title":"Neuropsychology"},{"issue":"4","key":"pone.0354280.ref070","doi-asserted-by":"crossref","first-page":"295","DOI":"10.7326\/0003-4819-148-4-200802190-00008","article-title":"Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration","volume":"148","author":"CONSORT Group","year":"2008","journal-title":"Ann Intern Med"},{"issue":"7441","key":"pone.0354280.ref071","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bmj.328.7441.702","article-title":"CONSORT statement: extension to cluster randomised trials","volume":"328","author":"CONSORT group","year":"2004","journal-title":"BMJ"},{"key":"pone.0354280.ref072","unstructured":"G*Power3 software. Version 3.1.9.7. D\u00fcsseldorf, DE: Heinrich Heine Universit\u00e4t D\u00fcsseldorf. 2020. http:\/\/www.gpower.hhu.de\/"},{"key":"pone.0354280.ref073","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3352\/jeehp.2021.18.17","article-title":"Sample size determination and power analysis using the G*Power software","volume":"18","author":"H Kang","year":"2021","journal-title":"J Educ Eval Health Prof"},{"key":"pone.0354280.ref074","volume-title":"Manual for the ASEBA School-age Forms & Profiles: An Integrated System of Multi-informant Assessment","author":"TM Achenbach","year":"2001"},{"key":"pone.0354280.ref075","volume-title":"Behavior Rating Inventory of Executive Function\u00ae, Second Edition (BRIEF\u00ae2)","author":"GA Gioia","year":"2015"},{"issue":"9","key":"pone.0354280.ref076","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1080\/09602011.2017.1411819","article-title":"Assessment of executive functions in children and adolescents with acquired brain injury (ABI) using a novel complex multi-tasking computerised task: The Jansari assessment of Executive Functions for Children (JEF-C\u00a9)","volume":"29","author":"Y Gilboa","year":"2019","journal-title":"Neuropsychol Rehabil"},{"key":"pone.0354280.ref077","volume-title":"NEPSY II [A Developmental Neuropsychological Assessment, Second Edition]: Contributo Alla Taratura Italiana","author":"C Urgesi","year":"2011"},{"issue":"6","key":"pone.0354280.ref078","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: psychometric properties","volume":"56","author":"AT Beck","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"pone.0354280.ref079","volume-title":"Parenting Stress Index \u2013 Fourth Edition (PSI-4)","author":"A Guarino","year":"2016"},{"key":"pone.0354280.ref080","article-title":"SCL-90.","volume-title":"Repertorio delle scale di valutazione in psichiatria","author":"GB Cassano","year":"1999"},{"key":"pone.0354280.ref081","volume-title":"IBM SPSS","year":"2023"},{"issue":"3","key":"pone.0354280.ref082","first-page":"423","article-title":"Pediatric rehabilitation of severe acquired brain injury: a multicenter survey","volume":"48","author":"S Gazzellini","year":"2012","journal-title":"Eur J Phys Rehabil Med"},{"key":"pone.0354280.ref083","doi-asserted-by":"crossref","DOI":"10.2196\/46957","article-title":"The Effect of Web-Based Telerehabilitation Programs on Children and Adolescents With Brain Injury: Systematic Review and Meta-Analysis","volume":"25","author":"Z Wang","year":"2023","journal-title":"J Med Internet Res"},{"issue":"8","key":"pone.0354280.ref084","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-029349","article-title":"Clinical and cost-effectiveness of teen online problem-solving for adolescents who have survived an acquired brain injury in the UK: protocol for a randomised, controlled feasibility study (TOPS-UK)","volume":"9","author":"J Limond","year":"2019","journal-title":"BMJ Open"},{"issue":"3","key":"pone.0354280.ref085","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/jayao.2023.0119","article-title":"Barriers to Care and Perceived Need for Mental Health Services Among Adolescent and Emerging Adult Survivors of Pediatric Brain Tumors","volume":"13","author":"AP Fisher","year":"2024","journal-title":"J Adolesc Young Adult Oncol"},{"issue":"1","key":"pone.0354280.ref086","first-page":"269","article-title":"Factors affecting therapeutic compliance: A review from the patient\u2019s perspective","volume":"4","author":"J Jin","year":"2008","journal-title":"Ther Clin Risk Manag"},{"issue":"3","key":"pone.0354280.ref087","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3390\/healthcare10030415","article-title":"A narrative review of the launch and the deployment of telemedicine in Italy during the COVID-19 pandemic","volume":"10","author":"D Giansanti","year":"2022","journal-title":"Healthcare"},{"issue":"6","key":"pone.0354280.ref088","article-title":"Online Family Problem-solving Treatment for Pediatric Traumatic Brain Injury","volume":"142","author":"SL Wade","year":"2018","journal-title":"Pediatrics"},{"issue":"2","key":"pone.0354280.ref089","first-page":"187","article-title":"Technology-assisted rehabilitation interventions following pediatric brain injury","volume":"62","author":"SL Wade","year":"2018","journal-title":"J Neurosurg Sci"},{"issue":"4","key":"pone.0354280.ref090","article-title":"Effect on behavior problems of teen online problem-solving for adolescent traumatic brain injury","volume":"128","author":"SL Wade","year":"2011","journal-title":"Pediatrics"},{"issue":"4","key":"pone.0354280.ref091","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176429","article-title":"Feasibility of computerized working memory training in individuals with Huntington disease","volume":"12","author":"M Sadeghi","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"pone.0354280.ref092","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1037\/a0030250","article-title":"Social problem solving, social cognition, and mild cognitive impairment in Parkinson\u2019s disease","volume":"127","author":"RJ Anderson","year":"2013","journal-title":"Behav Neurosci"},{"key":"pone.0354280.ref093","doi-asserted-by":"crossref","first-page":"1404518","DOI":"10.3389\/fpsyg.2024.1404518","article-title":"The feasibility and effectiveness of remote cognitive training on cognitive function and work performance in workers","volume":"15","author":"M Shibaoka","year":"2024","journal-title":"Front Psychol"},{"issue":"7","key":"pone.0354280.ref094","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/neu.2018.5885","article-title":"Examination of Injury, Host, and Social-Environmental Moderators of Online Family Problem Solving Treatment Efficacy for Pediatric Traumatic Brain Injury Using an Individual Participant Data Meta-Analytic Approach","volume":"36","author":"N Zhang","year":"2019","journal-title":"J Neurotrauma"},{"key":"pone.0354280.ref095","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fpubh.2018.00362","article-title":"Gender, Personality Traits and Experience With Psychiatric Patients as Predictors of Stigma in Italian Psychology Students","volume":"6","author":"L Zaninotto","year":"2018","journal-title":"Front Public Health"},{"key":"pone.0354280.ref096","author":"C Nyzio","year":"2021","journal-title":"Mental health in Italy: Systems, stigma, and impact of COVID-19"},{"key":"pone.0354280.ref097","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yebeh.2018.09.038","article-title":"Parents experience problems in psychological and family functioning two to four years after their child\u2019s epilepsy surgery","volume":"89","author":"O Braams","year":"2018","journal-title":"Epilepsy Behav"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0354280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:43:10Z","timestamp":1785260590000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0354280"}},"subtitle":[],"editor":[{"given":"Barry","family":"Kweh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":97,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0354280","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}