{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:28:21Z","timestamp":1789658901394,"version":"4.0.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sojitz Corporation"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["AMED; grant number JP25he2822009"],"award-info":[{"award-number":["AMED; grant number JP25he2822009"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["grant number 24K13524"],"award-info":[{"award-number":["grant number 24K13524"]}]},{"name":"Japan Science and Technology Agency (JST) through the Strategic Basic Research Programs, CREST","award":["grant number JPMJCR19A2"],"award-info":[{"award-number":["grant number JPMJCR19A2"]}],"id":[{"id":"https:\/\/ror.org\/00097mb19","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Presenteeism, attending work despite physical or mental health problems, is a major source of productivity loss worldwide, yet its early detection in everyday settings remains challenging. Conventional self-report instruments are time-consuming and require psychiatrist interpretation, which limits their scalability. We developed a multimodal machine-learning model that estimates work-function impairment as an indicator of presenteeism from brief smartphone-based dialogues. 38 employees recorded short self-report videos (10\u201330\u2009s) using front-facing smartphone cameras, which were independently rated on an ordinal three-level work-function scale (Healthy \/ Moderate \/ Unwell) by three psychiatrists; the consensus label served as supervision. We tested whether integrating multimodal behavioural signals (acoustic, facial, and linguistic) would provide additional cues beyond linguistic content alone, particularly when verbal cues are sparse. Acoustic, facial, and linguistic features were extracted from each clip and integrated using a three-stream Attention-based Multiple Instance Learning (Attention-MIL) framework with learned late fusion, an ordinal-regression head, and class-prior logit adjustment. Generalisation was assessed under a participant-disjoint protocol (25-fold repeated GroupKFold;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091,768 out-of-fold clips from 29 participants). On the Full configuration, the proposed multimodal framework achieved macro-F1\u2009=\u20090.772 (95% CI [0.697, 0.817]), accuracy\u2009=\u20090.840, macro-AUROC\u2009=\u20090.940, and low expected calibration error (ECE\n                    <jats:inline-formula id=\"pone.0354342.e001\">\n                      <jats:alternatives>\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"pone.0354342.e001g\" mimetype=\"image\" position=\"anchor\" xlink:href=\"info:doi\/10.1371\/journal.pone.0354342.e001\" xlink:type=\"simple\"\/>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" id=\"M1\">\n                          <mml:mrow>\n                            <mml:mo>\u2248<\/mml:mo>\n                            <mml:mn>0.024<\/mml:mn>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:alternatives>\n                    <\/jats:inline-formula>\n                    ). At the aggregate level, the four text-containing configurations (Full \/ Audio+Text \/ Face+Text \/ Text-only) were mutually indistinguishable on macro-F1 (Holm\u2013Bonferroni\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>adj<\/jats:sub>\n                    \u2009&gt;\u20090.40), whereas text-free configurations performed substantially worse (\n                    <jats:inline-formula id=\"pone.0354342.e002\">\n                      <jats:alternatives>\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"pone.0354342.e002g\" mimetype=\"image\" position=\"anchor\" xlink:href=\"info:doi\/10.1371\/journal.pone.0354342.e002\" xlink:type=\"simple\"\/>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" id=\"M2\">\n                          <mml:mrow>\n                            <mml:mo>\u0394<\/mml:mo>\n                            <mml:mo>&lt;<\/mml:mo>\n                            <mml:mo>\u2212<\/mml:mo>\n                            <mml:mn>0.33<\/mml:mn>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:alternatives>\n                    <\/jats:inline-formula>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>adj<\/jats:sub>\n                    \u2009&lt;\u20090.001), confirming the necessity of the linguistic channel. In an exploratory subgroup analysis, Audio+Text outperformed Text-only in the clinically ambiguous subgroup\u2014short-speech responses from non-Healthy participants (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200977;\n                    <jats:inline-formula id=\"pone.0354342.e003\">\n                      <jats:alternatives>\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"pone.0354342.e003g\" mimetype=\"image\" position=\"anchor\" xlink:href=\"info:doi\/10.1371\/journal.pone.0354342.e003\" xlink:type=\"simple\"\/>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" id=\"M3\">\n                          <mml:mrow>\n                            <mml:mo>\u0394<\/mml:mo>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:alternatives>\n                    <\/jats:inline-formula>\n                    macro-F1\u2009=+0.030, exploratory, requires replication). These findings provide localised but clinically meaningful support for the multimodal hypothesis under low-information conditions and motivate prospective replication.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0354342","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:01:57Z","timestamp":1789588917000},"page":"e0354342","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimating presenteeism from repeated smartphone-based multimodal behavioral responses"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3111-226X","authenticated-orcid":true,"given":"Taiga","family":"Noguchi","sequence":"first","affiliation":[{"name":"University of Tsukuba","place":["Tsukuba, Ibaraki, Japan"],"department":["Graduate School of Science and Technology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-9058","authenticated-orcid":true,"given":"Shotaro","family":"Doki","sequence":"additional","affiliation":[{"name":"University of Tsukuba","place":["Tsukuba, Ibaraki, Japan"],"department":["Institute of Medicine"]},{"name":"Minds in Co., Ltd.","place":["Chuo-ku, Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-3674","authenticated-orcid":true,"given":"Masakazu","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Minds in Co., Ltd.","place":["Chuo-ku, Tokyo, Japan"]},{"name":"NEC Corporation","place":["Meguro-ku, Tokyo, Japan"],"department":["Data Science Laboratories"]},{"name":"University of Tsukuba","place":["Tsukuba, Ibaraki, Japan"],"department":["Center for Cybernics Research"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Nishimura","sequence":"additional","affiliation":[{"name":"University of Tsukuba","place":["Tsukuba, Ibaraki, Japan"],"department":["Graduate School of Comprehensive Human Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Hotta","sequence":"additional","affiliation":[{"name":"Sojitz Corporation","place":["Chiyoda-ku, Tokyo, Japan"],"department":["Retail & Consumer Service Division"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Iwata","sequence":"additional","affiliation":[{"name":"Sojitz Corporation","place":["Chiyoda-ku, Tokyo, Japan"],"department":["Human Capital Dept. 2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Kouda","sequence":"additional","affiliation":[{"name":"Sojitz Corporation","place":["Chiyoda-ku, Tokyo, Japan"],"department":["Public Relations Dept."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"DG COMMUNICATIONS Co., Ltd.","place":["Shinjuku-ku, Tokyo, Japan"],"department":["Digital Business Division"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"University of Tsukuba","place":["Tsukuba, Ibaraki, Japan"],"department":["Institute of Systems and Information Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"7","key":"pone.0354342.ref001","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/jech.54.7.502","article-title":"Sick but yet at work. 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