{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:04:52Z","timestamp":1784837092086,"version":"3.55.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["Cooperatio"],"award-info":[{"award-number":["Cooperatio"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Type 2 diabetes is associated with small vessels dysfunction. This study assessed whether type 2 diabetes is associated with changes in the myocardial capillary pattern in two-dimensional histological sections as an indirect proxy for the three-dimensional network in the myocardium. We used myocardial samples from the left and right ventricles harvested during cardiac surgery (N\u2009=\u200953; 44 without and 9 with type 2 diabetes). We prepared histological sections with CD34-immunostained endothelium. We used cross-sections through the small vessels as points for two methods of point-pattern analysis: Voronoi-based analysis and fractal-based analysis. We were unable to detect differences in the microvascular pattern on myocardial sections of participants with and without type 2 diabetes.<\/jats:p>","DOI":"10.1371\/journal.pone.0354451","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:16:09Z","timestamp":1784834169000},"page":"e0354451","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myocardial microvascular patterns in histological sections from patients with and without type 2 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