{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:04:55Z","timestamp":1785175495521,"version":"3.55.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to determine whether patient\u2019s age and their primary tumor type act as independent predictors of their survival after a diagnosis of choroidal metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single-center study (August 2013 \u2013 August 2025) included 70 patients with choroidal metastases. Clinical data and multimodal imaging were extracted from medical records. Tumor volume was calculated from ultrasound measurements. Patients were grouped according to primary tumor origin (lung, breast, or other primaries). Survival was compared between these three primary tumor groups and according to age. Group differences in continuous variables were assessed using ANOVA\/Kruskal-Wallis testing, and survival distributions were analyzed with Kaplan-Meier curves. Patients were categorized into younger (&lt;59.6 years) and older (\u226559.6 years) groups for Kaplan-Meier survival analysis. Univariate and multivariate Cox regression models were performed to identify independent predictors of overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median overall survival was 71.6 weeks. Statistically significantly longer survival was found in patients &lt;59.6 years (median 88.3 weeks; estimated 3-year survival 33.2%) compared with those \u226559.6 years (median 41.9 weeks; 3-year survival 16.8%; p\u2009=\u20090.037. Primary tumor group analysis showed a median survival of 94.4 weeks for breast cancer (estimated 3-year survival 38.3%), 52.7 weeks for lung cancer (9,5%), and 40.6 weeks for other primaries (19.7%). However, this difference was not statistically significant (p\u2009=\u20090.269). In multivariate Cox regression analysis, age\u2009\u2265\u200959.6 years (HR 2.10; p\u2009=\u20090.016) and &gt;1 extraocular metastases elsewhere in the body (HR 2.53; p\u2009=\u20090.029) were independent predictors of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Survival in choroidal metastases is strongly driven by age and the number of extraocular metastatic sites at presentation. Our findings suggest that younger age and a lower metastatic burden are most reliable indicators for a more favorable prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0354598","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:39:30Z","timestamp":1785173970000},"page":"e0354598","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Choroidal metastasis: Impact of primary tumors and age on survival - a single center analysis"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8718-9530","authenticated-orcid":true,"given":"Philipp","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-4624","authenticated-orcid":true,"given":"Adrian","family":"Reumueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Kreminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zafeiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-2231","authenticated-orcid":true,"given":"Stefan","family":"Sacu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-7081","authenticated-orcid":true,"given":"Reinhard","family":"Told","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Dunavoelgyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"8","key":"pone.0354598.ref001","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3390\/cancers16081518","article-title":"Ocular and periocular metastasis in breast cancer: clinical characteristics, prognostic factors and treatment outcome","volume":"16","author":"YA Yousef","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"1","key":"pone.0354598.ref002","doi-asserted-by":"crossref","first-page":"15258","DOI":"10.1038\/s41598-024-64464-z","article-title":"Clinical features and treatment outcomes of intraocular and ocular adnexal metastasis","volume":"14","author":"WD Tsutsumi","year":"2024","journal-title":"Sci Rep"},{"key":"pone.0354598.ref003","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.2147\/OTT.S315532","article-title":"A comprehensive understanding of choroidal metastasis from lung cancer","volume":"14","author":"Z Qu","year":"2021","journal-title":"Onco Targets Ther"},{"issue":"2","key":"pone.0354598.ref004","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1440-1843.2007.01203.x","article-title":"Symptomatic ocular metastases in lung cancer","volume":"13","author":"H-T Su","year":"2008","journal-title":"Respirology"},{"issue":"3","key":"pone.0354598.ref005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0002-9394(02)01580-5","article-title":"Choroidal metastasis in disseminated lung cancer: frequency and risk factors","volume":"134","author":"K-M Kreusel","year":"2002","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"pone.0354598.ref006","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0161-6420(97)30148-1","article-title":"Survey of 520 eyes with uveal metastases","volume":"104","author":"CL Shields","year":"1997","journal-title":"Ophthalmology"},{"issue":"2","key":"pone.0354598.ref007","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/eye.2012.252","article-title":"Ocular metastases","volume":"27","author":"VML Cohen","year":"2013","journal-title":"Eye (Lond)"},{"issue":"2","key":"pone.0354598.ref008","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/bjo.80.2.125","article-title":"Frequency of ocular metastases in patients dying of cancer in eye bank populations","volume":"80","author":"B Eliassi-Rad","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"pone.0354598.ref009","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-4419-0374-7_16","article-title":"Uveal metastases from solid tumors","author":"GD Camoriano","year":"2010","journal-title":"Ophthalmic Oncology"},{"issue":"5","key":"pone.0354598.ref010","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41433-022-02015-4","article-title":"Metastatic tumours to the eye. 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