{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:52:33Z","timestamp":1792788753371,"version":"4.5.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MDL Fonds","award":["ZP 21-13"],"award-info":[{"award-number":["ZP 21-13"]}]},{"name":"Maastricht University","award":["N\/A (Partial Salary)"],"award-info":[{"award-number":["N\/A (Partial Salary)"]}],"id":[{"id":"https:\/\/ror.org\/02jz4aj89","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Purpose<\/jats:title>\n \n To develop predictive equations for oxygen uptake at peak exercise (VO\n 2peak<\/jats:sub>\n ) measured during a cardiopulmonary exercise test (CPET) for patients with inflammatory bowel disease (IBD) using submaximal CPET-derived parameters and the steep ramp test, along with demographic and clinical characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study included patients with IBD in remission or with mild-to-moderate disease activity who performed a CPET and a steep ramp test within 14 days. Submaximal CPET-derived parameters included oxygen uptake (VO\n 2<\/jats:sub>\n ) at the ventilatory anaerobic threshold (VAT) and oxygen uptake efficiency slope (OUES), while the outcome of the steep ramp test was the work rate achieved at peak exercise (WR\n peak<\/jats:sub>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Predictive regression equations with submaximal VO\n 2<\/jats:sub>\n at the VAT and with OUES, when combined with age and body fat percentage, explained >89% of the variance in VO\n 2peak<\/jats:sub>\n (optimism-adjusted R\n 2<\/jats:sup>\n \u2009=\u20090.895 and 0.938). Predictive capacity increased when both VO\n 2<\/jats:sub>\n at the VAT and OUES were combined in a predictive regression equation, together with age, body fat percentage, and clinically active disease (optimism-adjusted R\n 2<\/jats:sup>\n \u2009=\u20090.951). Steep ramp test WR\n peak<\/jats:sub>\n explained 89% of the variance in VO\n 2peak<\/jats:sub>\n (optimism-adjusted R\n 2<\/jats:sup>\n \u2009=\u20090.892).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The highly predictive equations developed in this study support the use of the submaximal CPET and the steep ramp test as alternatives for assessing VO\n 2peak<\/jats:sub>\n in patients with IBD in remission or with mild-to-moderate disease activity in clinical and research settings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0354707","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:25:57Z","timestamp":1791480357000},"page":"e0354707","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of oxygen uptake at peak exercise in patients with inflammatory bowel disease using submaximal cardiopulmonary exercise testing and the steep ramp test as a practical field test"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-9959","authenticated-orcid":true,"given":"Karlijn","family":"Demers","sequence":"first","affiliation":[{"name":"Maastricht University Medical Center+","place":["Maastricht, the Netherlands"],"department":["Department of Surgery"]},{"name":"Maastricht University Medical Center+","place":["Maastricht, the Netherlands"],"department":["Department of Gastroenterology-Hepatology"]},{"name":"Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University","place":["Maastricht, the Netherlands"],"department":["Department of Surgery"]},{"name":"Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University","place":["Maastricht, the Netherlands"],"department":["Department of Gastroenterology-Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander M. J.","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center+","place":["Maastricht, the Netherlands"],"department":["Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke J.","family":"Pierik","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center+","place":["Maastricht, the Netherlands"],"department":["Department of Gastroenterology-Hepatology"]},{"name":"Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University","place":["Maastricht, the Netherlands"],"department":["Department of Gastroenterology-Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy M. A. E.","family":"Jonkers","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University","place":["Maastricht, the Netherlands"],"department":["Department of Gastroenterology-Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurents P. S.","family":"Stassen","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center+","place":["Maastricht, the Netherlands"],"department":["Department of Surgery"]},{"name":"Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University","place":["Maastricht, the Netherlands"],"department":["Department of Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1948-9788","authenticated-orcid":true,"given":"Bart C.","family":"Bongers","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University","place":["Maastricht, the Netherlands"],"department":["Department of Surgery"]},{"name":"Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University","place":["Maastricht, the Netherlands"],"department":["Department of Nutrition and Movement 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Wasserman","year":"1973","journal-title":"J Appl Physiol"},{"issue":"6","key":"pone.0354707.ref018","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0735-1097(96)00412-3","article-title":"Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise","volume":"28","author":"R Baba","year":"1996","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"pone.0354707.ref019","first-page":"1178","article-title":"\u201cAnaerobic threshold\u201d: problems of determination and validation","volume":"55","author":"MP Yeh","year":"1983","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"issue":"11","key":"pone.0354707.ref020","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1365-2044.2009.06074.x","article-title":"Determination of the anaerobic threshold in the pre-operative assessment clinic: inter-observer measurement 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