{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:05:27Z","timestamp":1785434727240,"version":"3.56.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovad (Thailand) Company Limited","award":["00134"],"award-info":[{"award-number":["00134"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>This study investigated the effects of a complex mycotoxin detoxifier (CMD) on growth performance, liver health, inflammation, and redox status of broilers fed a diet contaminated with multiple mycotoxins. A total of 432 one-day-old male Ross 308 broiler chicks were randomly allocated to one of three treatments, with eight replicates per dietary group for 37 d. The treatment included: a basal diet without mycotoxin, positive control, PC; a basal diet contaminated with 80 ppb Aflatoxin\u2009+\u2009900 ppb fumonisins\u2009+\u200930 ppb deoxynivalenol\u2009+\u200980 ppb Zearalenone, negative control, NC or NC supplemented with CMD (sodium bentonite, sepiolite, yeast cell wall, and \u03b2-glucans) at 1 and 0.5 kg\/ton in the starter and finisher diet respectively. Compared with the PC and CMD groups, NC birds showed higher feed intake and poorer feed efficiency during days 1\u201310 (p\u2009&lt;\u20090.05), although these differences were not observed thereafter. Newcastle disease antibody titer was reduced in NC birds but restored by CMD supplementation (p\u2009&lt;\u20090.05). Birds receiving CMD also exhibited higher IL-10 concentrations than both PC and NC birds (p\u2009&lt;\u20090.05). Furthermore, CMD supplementation reduced macroscopic fatty liver scores and liver inflammation (histopathological lesions) compared with the NC group (p\u2009&lt;\u20090.05). In conclusion, dietary exposure to multiple mycotoxins caused only transient impairment of growth performance but adversely affected immune response and liver health. Supplementation with CMD at 1.0 and 0.5 kg\/ton during the starter and finisher phases, respectively, alleviated several of these adverse effects in broiler chickens.<\/jats:p>","DOI":"10.1371\/journal.pone.0354753","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:29:21Z","timestamp":1785432561000},"page":"e0354753","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of a complex mycotoxin detoxifier on growth performance, liver health, inflammation, and redox status of broilers fed a diet contaminated with multiple mycotoxins"],"prefix":"10.1371","volume":"21","author":[{"given":"Nampetch","family":"Puengpong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaweesak","family":"Songserm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konkawat","family":"Rassmidatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Torrent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Khadem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnau","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Gougoulias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithikarn","family":"Chanaksorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazeem D.","family":"Adeyemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-6300","authenticated-orcid":true,"given":"Yuwares","family":"Ruangpanit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"3","key":"pone.0354753.ref001","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1111\/1541-4337.13121","article-title":"Current and future interventions for improving poultry health and poultry food safety and security: a comprehensive review","volume":"22","author":"MAH Chowdhury","year":"2023","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"pone.0354753.ref002","volume-title":"Food Outlook: Biannual Report on Global Food Markets","author":"Food and Agriculture Organization of the United Nations","year":"2024"},{"key":"pone.0354753.ref003","volume-title":"OECD-FAO Agricultural Outlook 2024\u20132033","author":"Organization for Economic Co-operation and Development, Food and Agriculture Organization of the United Nations","year":"2024"},{"issue":"1","key":"pone.0354753.ref004","doi-asserted-by":"crossref","first-page":"70","DOI":"10.47262\/BL\/8.1.20210901","article-title":"Poultry feed contamination and its potential hazards on human health","volume":"8","author":"S Suleman","year":"2022","journal-title":"Biomed Lett"},{"issue":"3","key":"pone.0354753.ref005","first-page":"4834","article-title":"Microbial contamination of poultry feed and the effects on birds\u2019 performance","volume":"20","author":"AC Mgbeahuruike","year":"2023","journal-title":"Anim Res Int"},{"key":"pone.0354753.ref006","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.anifeedsci.2006.08.005","article-title":"The risk of contamination of food with toxic substances present in animal feed","volume":"133","author":"CA Kan","year":"2007","journal-title":"Anim Feed Sci Technol"},{"key":"pone.0354753.ref007","volume-title":"Hazards associated with animal feed. 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