{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:50:32Z","timestamp":1785523832731,"version":"3.56.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The widespread use of herbal medicines in clinical practice, particularly in Southeast Asia, presents significant challenges for medication safety management, notably regarding interactions between herbs and conventional drugs. Current drug interaction screening tools demonstrate substantial gaps in documenting herb-drug interactions, especially for regionally specific medicinal plants, creating potential risks for patients receiving concurrent therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>(1) to identify the prevalence of potential herb\u2013drug and herb\u2013herb interactions and the disclosure rate of HM use in patients with NCDs; and (2) to assess the consistency of interaction information across commonly used drug interaction databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An observational study enrolled 658 patients with non-communicable diseases from two Vietnamese tertiary care facilities. Structured interviews captured herbal medicine utilization patterns, disclosure practices, and specific botanical preparations used. Potential herb-drug and herb-herb interactions were systematically evaluated using four databases: Micromedex\u00ae, UpToDate Lexicomp Drug Interactions, Medscape Drug Interaction Checker, and Stockley\u2019s Herbal Medicines Interactions. Inter-database agreement was assessed using Fleiss\u2019 kappa statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>48.6% of participants reported active herbal medicines use, with 96% failing to disclose this to their healthcare providers. Potential interactions were identified in 31.3% of herbal medicine users, representing 15.2% of the total cohort. Database concordance was remarkably poor, with only 0.7% of interactions consistently documented across all four resources (Fleiss\u2019 \u03ba\u2009=\u2009\u20130.0653; p\u2009&lt;\u20090.001). Multiple indigenous medicinal plants commonly used by patients were absent from all evaluated databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The substantial prevalence of undisclosed herbal medicine use, alongside inadequate representation in drug interaction databases, represents a critical gap in medication safety infrastructure. These findings demonstrated the necessity for integrating herbal medicine assessment into routine care, enhanced provider training, and expansion of clinical decision support systems to include region-specific botanical data for populations using concurrent traditional and conventional therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0355046","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:28:36Z","timestamp":1785518916000},"page":"e0355046","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Herbal medicine use disclosure, database-flagged potential herb-drug interactions, and inter \u2013 interaction database concordance among patients with non-communicable diseases in Vietnam: A multicenter cross-sectional study"],"prefix":"10.1371","volume":"21","author":[{"given":"Anh Dang Thuc","family":"Phan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Ha","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tram Nguyen Nguyet","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang Thu Thi","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4588-9777","authenticated-orcid":true,"given":"Chuenjid","family":"Kongkaew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"pone.0355046.ref001","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/B978-0-323-85542-6.00001-9","article-title":"Chapter 9 - Pharmacovigilance of herbal medicines: The vigilance of tomorrow.","volume-title":"Evidence-Based Validation of Herbal Medicine","author":"S Skalli","year":"2022","edition":"2"},{"key":"pone.0355046.ref002","doi-asserted-by":"crossref","first-page":"101328","DOI":"10.1016\/j.eujim.2021.101328","article-title":"Use 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