{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:25:41Z","timestamp":1787163941495,"version":"build-2736575974"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016117","name":"Hanns-Seidel-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004350","name":"Studienstiftung des Deutschen Volkes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Trimming of vibrissae in dogs (\n                    <jats:italic>Canis lupus familiaris<\/jats:italic>\n                    ) for cosmetic reasons remains a common practice, particularly among poodle breeds and show dogs. In discussions surrounding this practice, it has been claimed that domestic dogs would have fewer and structurally less developed sinus hairs than other mammals, and that, especially in poodles, vibrissae would lack functional relevance, although such narratives represent popularized assumptions rather than systematically supported peer-reviewed evidence. The follicle-sinus complexes (FSCs) of various species, including cats (\n                    <jats:italic>Felis catus<\/jats:italic>\n                    ), rats (\n                    <jats:italic>Rattus norvegicus<\/jats:italic>\n                    ), and marine mammals, have been characterized in detail with respect to their innervation and mechanoreceptor organization. However, comparable histomorphological analyses of canine FSCs have not yet been conducted. Providing an in-depth morphological characterization of canine FSCs, the present study examined facial skin samples from 44 dogs of different ages, breeds (including poodles), and sexes, with assessment of FSC number and size. Regardless of breed, an average of 60\u2009\u00b1\u200913 FSCs per dog was identified in the present study (with a regional distribution of 28\u2009\u00b1\u20097 mystacial, 9\u2009\u00b1\u20092 supraorbital, 16\u2009\u00b1\u20097 mandibular, and 7\u2009\u00b1\u20092 buccal FSCs). Mystacial FSCs were the longest, measuring 4.0\u2009\u00b1\u20091.1 mm in length and 1.7\u2009\u00b1\u20090.6 mm in width. FSC length and width were significantly positively associated with body weight across all investigated facial regions. FSCs were characterized using histological, immunohistochemical (PGP 9.5, NF200, S100, GFAP), ultrastructural, and quantitative-morphological analyses. Canine FSCs demonstrate a complex mechanosensory architecture that includes Merkel cell-neurite complexes, lanceolate endings, reticular endings, and presumptive free nerve endings located in specific regions of the FSC. Quantitative analyses showed that neuronal tissue accounted for 13.6%\u2009\u00b1\u20093.3% (vol.) of the internal FSC compartments. No evidence was found of a species- or breed-specific reduction in the structural or sensory capacity of canine FSCs.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0355554","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:38:45Z","timestamp":1787161125000},"page":"e0355554","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histomorphological and ultrastructural analysis of vibrissal follicle-sinus complexes in the dog (Canis lupus familiaris)"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6685-8041","authenticated-orcid":true,"given":"Helen Edith","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Bliemel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Franzmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fuchs-Baumgartinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"Gerics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3494-6236","authenticated-orcid":true,"given":"Pauline","family":"P\u00f6pperl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouven","family":"Wannemacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-9791","authenticated-orcid":true,"given":"Sven","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-2179","authenticated-orcid":true,"given":"Dorothea","family":"D\u00f6ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Matiasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Blutke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"4","key":"pone.0355554.ref001","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF02213989","article-title":"The role of vibrissae in behavior: a status review","volume":"10","author":"AS Ahl","year":"1986","journal-title":"Vet Res Commun"},{"issue":"1","key":"pone.0355554.ref002","first-page":"339","article-title":"On the microstructure of receptors on sinus hair","volume":"75","author":"KH Andres","year":"1966","journal-title":"Z Zellforsch Mikrosk Anat"},{"issue":"2","key":"pone.0355554.ref003","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cne.902520203","article-title":"A comparative light microscopic analysis of the sensory innervation of the mystacial pad. 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Innervation of vibrissal follicle-sinus complexes","volume":"252","author":"FL Rice","year":"1986","journal-title":"J Comp Neurol"},{"issue":"4","key":"pone.0355554.ref004","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/cne.901920403","article-title":"Sensory nerve endings in rhesus monkey sinus hairs","volume":"192","author":"Z Halata","year":"1980","journal-title":"J Comp Neurol"},{"key":"pone.0355554.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.900230101","article-title":"The tactile hair of the white rat","volume":"23","author":"S Vincent","year":"1913","journal-title":"J Comp Neurol"},{"issue":"1","key":"pone.0355554.ref006","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/mam.12253","article-title":"What can whiskers tell us about mammalian evolution, behaviour, and ecology?","volume":"52","author":"RA Grant","year":"2021","journal-title":"Mammal 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Reese","year":"2020","edition":"6"},{"issue":"3","key":"pone.0355554.ref011","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/a-1162-1370","article-title":"Bedeutung der Tasthaare beim Haushund und Problematik des Abschneidens aus Sicht des Tierschutzes","volume":"48","author":"D D\u00f6ring","year":"2020","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"issue":"6","key":"pone.0355554.ref012","first-page":"359","article-title":"Amputation of vibrissae in show dogs","volume":"1","author":"TE McGill","year":"1980","journal-title":"International Journal for the Study of Animal Problems"},{"key":"pone.0355554.ref013","author":"G Dehnhardt","year":"2001"},{"key":"pone.0355554.ref014","author":"B Kipp","year":"2023"},{"issue":"2","key":"pone.0355554.ref015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1096-9861(19970825)385:2<149::AID-CNE1>3.0.CO;2-1","article-title":"Comprehensive immunofluorescence and lectin binding analysis of vibrissal follicle sinus complex innervation in the mystacial pad of the rat","volume":"385","author":"FL Rice","year":"1997","journal-title":"J Comp Neurol"},{"issue":"3","key":"pone.0355554.ref016","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/cne.903370303","article-title":"The innervation of the mystacial pad of the rat as revealed by PGP 9.5 immunofluorescence","volume":"337","author":"FL Rice","year":"1993","journal-title":"J Comp Neurol"},{"issue":"2","key":"pone.0355554.ref017","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cne.10277","article-title":"Similarities and differences in the innervation of mystacial vibrissal follicle-sinus complexes in the rat and cat: a confocal microscopic study","volume":"449","author":"S Ebara","year":"2002","journal-title":"J Comp Neurol"},{"issue":"4","key":"pone.0355554.ref018","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000264662","article-title":"Aquatic environment and differentiation of vibrissae: comparison of sinus hair systems of ringed seal, otter and pole cat","volume":"74","author":"H Hyv\u00e4rinen","year":"2009","journal-title":"Brain Behav Evol"},{"issue":"4","key":"pone.0355554.ref019","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/ar.1091760406","article-title":"Innervation of the vibrissae of the California sea lion, Zalophus californianus","volume":"176","author":"RJ Stephens","year":"1973","journal-title":"Anat Rec"},{"issue":"3","key":"pone.0355554.ref020","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cne.21446","article-title":"Adaptations in the structure and innervation of follicle-sinus complexes to an aquatic environment as seen in the Florida manatee (Trichechus manatus latirostris)","volume":"504","author":"DK Sarko","year":"2007","journal-title":"J Comp Neurol"},{"issue":"9","key":"pone.0355554.ref021","doi-asserted-by":"crossref","DOI":"10.1002\/jmor.21628","article-title":"Describing whisker morphology of the Carnivora","volume":"284","author":"G Dougill","year":"2023","journal-title":"J Morphol"},{"key":"pone.0355554.ref022","doi-asserted-by":"crossref","first-page":"109752","DOI":"10.1016\/j.jneumeth.2022.109752","article-title":"Demonstrating a measurement protocol for studying comparative whisker movements with implications for the evolution of behaviour","volume":"384","author":"RA Grant","year":"2023","journal-title":"J Neurosci Methods"},{"key":"pone.0355554.ref023","first-page":"43","article-title":"Beitr\u00e4ge zur mikroskopischen und vergleichenden Anatomie der Sinushaare bei einigen S\u00e4ugetieren","volume":"9","author":"M Ueda","year":"1941","journal-title":"Japanese Journal of Medical Science and Biology"},{"issue":"2","key":"pone.0355554.ref024","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ajpa.22206","article-title":"Comparative histomorphology of intrinsic vibrissa musculature among primates: implications for the evolution of sensory ecology and \u201cface touch\u201d","volume":"150","author":"MN Muchlinski","year":"2013","journal-title":"Am J Phys Anthropol"},{"issue":"3","key":"pone.0355554.ref025","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.rvsc.2014.10.006","article-title":"Morphologic and immunohistochemical features of Merkel cells in the dog","volume":"97","author":"GA Ram\u00edrez","year":"2014","journal-title":"Res Vet Sci"},{"issue":"9","key":"pone.0355554.ref026","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/ar.23387","article-title":"Anatomical Mapping and Density of Merkel Cells in Skin and Mucosae of the Dog","volume":"299","author":"GA Ram\u00edrez","year":"2016","journal-title":"Anat Rec (Hoboken)"},{"issue":"1","key":"pone.0355554.ref027","doi-asserted-by":"crossref","first-page":"9212","DOI":"10.1038\/s41598-025-91629-1","article-title":"The canine vibrissal system as a highly innervated and functional sensory organ","volume":"15","author":"D D\u00f6ring","year":"2025","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0355554.ref028","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000381415","article-title":"Elaboration and Innervation of the Vibrissal System in the Rock Hyrax (Procavia capensis)","volume":"85","author":"DK Sarko","year":"2015","journal-title":"Brain Behav Evol"},{"issue":"12","key":"pone.0355554.ref029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243462","article-title":"A practical guide to unbiased quantitative morphological analyses of the gills of rainbow trout (Oncorhynchus mykiss) in ecotoxicological studies","volume":"15","author":"S Fiedler","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"pone.0355554.ref030","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/(SICI)1096-9861(19971229)389:4<545::AID-CNE1>3.0.CO;2-0","article-title":"Different distributions of the sensory and autonomic innervation among the microvasculature of the rat mystacial pad","volume":"389","author":"BT Fundin","year":"1997","journal-title":"J Comp Neurol"},{"key":"pone.0355554.ref031","author":"M Krehbiehl","year":"2010"},{"issue":"21","key":"pone.0355554.ref032","doi-asserted-by":"crossref","first-page":"15559","DOI":"10.3390\/ijms242115559","article-title":"Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury","volume":"24","author":"EA Konnova","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"8","key":"pone.0355554.ref033","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3390\/biomedicines9081022","article-title":"Discrepancy in the Usage of GFAP as a Marker of Satellite Glial Cell Reactivity","volume":"9","author":"KM Mohr","year":"2021","journal-title":"Biomedicines"},{"issue":"4","key":"pone.0355554.ref034","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/jnr.490230405","article-title":"Neuronal modulation of Schwann cell glial fibrillary acidic protein (GFAP)","volume":"23","author":"K Mokuno","year":"1989","journal-title":"J Neurosci Res"},{"issue":"1","key":"pone.0355554.ref035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neures.2006.09.014","article-title":"Blocking the glial function suppresses subcutaneous formalin-induced nociceptive behavior in the rat","volume":"57","author":"L Lan","year":"2007","journal-title":"Neurosci Res"},{"key":"pone.0355554.ref036","volume-title":"Unbiased stereology: three-dimensional measurement in microscopy","author":"CV Howard","year":"1998"},{"issue":"1","key":"pone.0355554.ref037","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.30.1.23","article-title":"Practical stereological methods for morphometric cytology","volume":"30","author":"ER Weibel","year":"1966","journal-title":"J Cell Biol"},{"issue":"7","key":"pone.0355554.ref038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158977","article-title":"Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle","volume":"11","author":"A Rieger","year":"2016","journal-title":"PLoS One"},{"key":"pone.0355554.ref039","doi-asserted-by":"crossref","first-page":"109272","DOI":"10.1016\/j.jneumeth.2021.109272","article-title":"A new method for physical disector analyses of numbers and mean volumes of immunohistochemically labeled cells in paraffin sections","volume":"361","author":"I Hofmann","year":"2021","journal-title":"J Neurosci Methods"},{"issue":"5","key":"pone.0355554.ref040","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12709","article-title":"Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth","volume":"4","author":"A Blutke","year":"2016","journal-title":"Physiol Rep"},{"issue":"133","key":"pone.0355554.ref041","doi-asserted-by":"crossref","DOI":"10.3791\/57276","article-title":"Sampling strategies and processing of biobank tissue samples from porcine biomedical models","author":"A Blutke","year":"2018","journal-title":"J Vis Exp"},{"issue":"3","key":"pone.0355554.ref042","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/0192623316631023","article-title":"Tissue Sampling Guides for Porcine Biomedical Models","volume":"44","author":"B Albl","year":"2016","journal-title":"Toxicol Pathol"},{"issue":"5","key":"pone.0355554.ref043","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1083\/jcb.3.5.827","article-title":"Effects of varying the vehicle for OsO4 in tissue fixation","volume":"3","author":"JB Caulfield","year":"1957","journal-title":"J Biophys Biochem Cytol"},{"issue":"3","key":"pone.0355554.ref044","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00495658","article-title":"Postembedding immunohistochemical demonstration of antigen in experimental polyarthritis using plastic embedded whole joints","volume":"73","author":"W Hermanns","year":"1981","journal-title":"Histochemistry"},{"key":"pone.0355554.ref045","article-title":"Toluidine Blue Staining of Resin-Embedded Sections for Evaluation of Peripheral Nerve Morphology","volume":"137","author":"AB Ghnenis","year":"2018","journal-title":"J Vis Exp"},{"issue":"1","key":"pone.0355554.ref046","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","article-title":"The use of lead citrate at high pH as an electron-opaque stain in electron microscopy","volume":"17","author":"ES Reynolds","year":"1963","journal-title":"J Cell Biol"},{"issue":"4","key":"pone.0355554.ref047","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/(SICI)1096-9861(19990906)411:4<550::AID-CNE2>3.0.CO;2-G","article-title":"Structure and innervation of the vibrissal follicle-sinus complex in the Australian water rat, Hydromys chrysogaster","volume":"411","author":"G Dehnhardt","year":"1999","journal-title":"J Comp Neurol"},{"issue":"6","key":"pone.0355554.ref048","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jhevol.2010.01.012","article-title":"A comparative analysis of vibrissa count and infraorbital foramen area in primates and other mammals","volume":"58","author":"MN Muchlinski","year":"2010","journal-title":"J Hum Evol"},{"key":"pone.0355554.ref049","first-page":"147","article-title":"The musculature of the mystacial vibrissae of the white mouse","volume":"135","author":"J D\u00f6rfl","year":"1982","journal-title":"J Anat"},{"issue":"3","key":"pone.0355554.ref050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000319394","article-title":"The morphology of the rat vibrissal follicle-sinus complex revealed by three-dimensional computer-aided reconstruction","volume":"193","author":"J-N Kim","year":"2011","journal-title":"Cells Tissues Organs"},{"issue":"6","key":"pone.0355554.ref051","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1159\/000338332","article-title":"A mechanism of rat vibrissal movement based on actual morphology of the intrinsic muscle using three-dimensional reconstruction","volume":"196","author":"J-N Kim","year":"2012","journal-title":"Cells Tissues Organs"},{"issue":"7","key":"pone.0355554.ref052","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/ar.21156","article-title":"Muscle architecture in the mystacial pad of the rat","volume":"293","author":"S Haidarliu","year":"2010","journal-title":"Anat Rec (Hoboken)"},{"key":"pone.0355554.ref053","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnbeh.2012.00039","article-title":"The role of orienting in vibrissal touch sensing","volume":"6","author":"RA Grant","year":"2012","journal-title":"Front Behav Neurosci"},{"key":"pone.0355554.ref054","first-page":"3483","article-title":"The evolution of active vibrissal sensing in mammals: evidence from vibrissal musculature and function in the marsupial opossum Monodelphis domestica","volume":"216","author":"RA Grant","year":"2013","journal-title":"J Exp Biol"},{"key":"pone.0355554.ref055","doi-asserted-by":"crossref","first-page":"125773","DOI":"10.1016\/j.zool.2020.125773","article-title":"MORPHOLOGICAL DIVERSITY OF FACIAL VIBRISSAE IN Chaetophractus vellerosus (MAMMALIA, XENARTHRA, DASYPODIDAE) AND DIFFERENTIAL MECHANOPERCEPTION","volume":"140","author":"CM Krmpotic","year":"2020","journal-title":"Zoology (Jena)"},{"issue":"3","key":"pone.0355554.ref056","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1113\/jphysiol.1969.sp008721","article-title":"The structure and function of a slowly adapting touch corpuscle in hairy skin","volume":"200","author":"A Iggo","year":"1969","journal-title":"J Physiol"},{"issue":"1","key":"pone.0355554.ref057","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0006-8993(71)90416-1","article-title":"The Merkel rete papilla--a slowly adapting sensory receptor in mammalian glabrous skin","volume":"29","author":"BL Munger","year":"1971","journal-title":"Brain Res"},{"issue":"2","key":"pone.0355554.ref058","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neures.2008.02.004","article-title":"Three-dimensional analyses of touch domes in the hairy skin of the cat paw reveal morphological substrates for complex sensory processing","volume":"61","author":"S Ebara","year":"2008","journal-title":"Neurosci Res"},{"issue":"4","key":"pone.0355554.ref059","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/cne.10196","article-title":"Distribution and terminal arborizations of cutaneous mechanoreceptors in the glabrous finger pads of the monkey","volume":"445","author":"M Par\u00e9","year":"2002","journal-title":"J Comp Neurol"},{"issue":"4517","key":"pone.0355554.ref060","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1126\/science.7280690","article-title":"Merkel cell receptors: structure and transducer function","volume":"214","author":"KM Gottschaldt","year":"1981","journal-title":"Science"},{"issue":"1","key":"pone.0355554.ref061","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/08990229009144697","article-title":"Responses of rat trigeminal ganglion neurons to movements of vibrissae in different directions","volume":"7","author":"SH Lichtenstein","year":"1990","journal-title":"Somatosens Mot Res"},{"issue":"1","key":"pone.0355554.ref062","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cne.902460109","article-title":"Degeneration and regeneration of peripheral nerve in the rat trigeminal system. I. Identification and characterization of the multiple afferent innervation of the mystacial vibrissae","volume":"246","author":"WE Renehan","year":"1986","journal-title":"J Comp Neurol"},{"issue":"5","key":"pone.0355554.ref063","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/ahe.12293","article-title":"Ultrastructural, Sensory and Functional Anatomy of the Northern Elephant Seal (Mirounga angustirostris) Facial Vibrissae","volume":"46","author":"H Smodlaka","year":"2017","journal-title":"Anat Histol Embryol"},{"key":"pone.0355554.ref064","first-page":"401","article-title":"The morphology and innervation of facial vibrissae in the tammar wallaby, Macropus eugenii","author":"LR Marotte","year":"1992","journal-title":"J Anat"},{"issue":"1","key":"pone.0355554.ref065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1006\/dbio.1997.8658","article-title":"Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR","volume":"190","author":"BT Fundin","year":"1997","journal-title":"Dev Biol"},{"issue":"2","key":"pone.0355554.ref066","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jmor.1051530211","article-title":"Structure of the sinus hair follicle in the big-clawed shrew, Sorex unguiculatus","volume":"153","author":"T Yohro","year":"1977","journal-title":"J Morphol"},{"issue":"5","key":"pone.0355554.ref067","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF00190140","article-title":"Unmyelinated innervation of sinus hair follicles in rats","volume":"188","author":"PM Waite","year":"1993","journal-title":"Anat Embryol (Berl)"},{"issue":"10","key":"pone.0355554.ref068","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2183\/pjab.91.560","article-title":"Structure-function correlations of rat trigeminal primary neurons: Emphasis on club-like endings, a vibrissal mechanoreceptor","volume":"91","author":"S Tonomura","year":"2015","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"issue":"5","key":"pone.0355554.ref069","first-page":"3","article-title":"The mechanoreceptors of the mammalian skin ultrastructure and morphological classification","volume":"50","author":"Z Halata","year":"1975","journal-title":"Adv Anat Embryol Cell Biol"},{"issue":"1","key":"pone.0355554.ref070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ar.a.20273","article-title":"Microstructure and innervation of the mystacial vibrissal follicle-sinus complex in bearded seals, Erignathus barbatus (Pinnipedia: Phocidae)","volume":"288","author":"CD Marshall","year":"2006","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"issue":"3","key":"pone.0355554.ref071","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.stemcr.2017.07.017","article-title":"Neural crest cell implantation restores enteric nervous system function and alters the gastrointestinal transcriptome in human tissue-engineered small intestine","volume":"9","author":"CR Schlieve","year":"2017","journal-title":"Stem Cell Reports"},{"issue":"1","key":"pone.0355554.ref072","doi-asserted-by":"crossref","first-page":"10860","DOI":"10.1038\/s41598-019-47221-5","article-title":"3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy","volume":"9","author":"CM Fran\u00e7a","year":"2019","journal-title":"Sci Rep"},{"key":"pone.0355554.ref073","year":"2026"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0355554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:38:55Z","timestamp":1787161135000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0355554"}},"subtitle":[],"editor":[{"given":"Silvana","family":"Allodi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":73,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0355554","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]}}}