{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:07:18Z","timestamp":1789150038392,"version":"build-2803163510"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Health, the Institute of Health Carlos III, the European Regional Development Fund \u00abUna manera de hacer Europa\u00bb","award":["grant references: PI15\/00401; PI15\/01035; PI15\/01021"],"award-info":[{"award-number":["grant references: PI15\/00401; PI15\/01035; PI15\/01021"]}]},{"name":"Andalusian Council of Health","award":["grant reference: AP-0095-2016"],"award-info":[{"award-number":["grant reference: AP-0095-2016"]}]},{"name":"Prevention and Health Promotion Research Network \u2018redIAPP\u2019","award":["RD16\/0007\/0010; RD16\/0007\/0005; RD16\/0007\/0003; RD16\/0007\/0001"],"award-info":[{"award-number":["RD16\/0007\/0010; RD16\/0007\/0005; RD16\/0007\/0003; RD16\/0007\/0001"]}]},{"name":"Chronicity, Primary Care and Health Promotion Research Network \u2018RICAPPS\u2019","award":["RD21\/0016\/0012; RD21\/0016\/0005; RD21\/0016\/0010 ; RD21\/0016\/0001"],"award-info":[{"award-number":["RD21\/0016\/0012; RD21\/0016\/0005; RD21\/0016\/0010 ; RD21\/0016\/0001"]}]},{"name":"Ministry of Health of Andalusia","award":["(PS-0330-2016"],"award-info":[{"award-number":["(PS-0330-2016"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The predictD intervention, delivered by family physicians (FPs), has demonstrated effectiveness and cost-efficiency in preventing depression and anxiety. The e-predictD study aims to design, develop, and evaluate a novel personalized intervention for depression prevention by integrating information and communication technologies (ICTs), risk prediction algorithms, and decision support systems (DSS) for both patients and FPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the satisfaction, usability, and acceptability, of a beta version of the e-predictD intervention in primary care settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The e-predictD intervention follows a biopsychosocial approach, including an initial patient-FP interview, specific FP training, and an app. A \u03b2-version was tested in a pilot study without a control group over three months. The app integrates a validated depression risk prediction algorithm, decision algorithms, and a monitoring system supporting the DSS. The DSS generates a personalized prevention plan (PPP) from eight intervention modules: physical exercise, social relationships, problem-solving, communication skills, decision-making, assertiveness, sleep improvement, and cognitive restructuring. Patients and FPs discussed the PPP in a 15-minute baseline interview, selecting modules for implementation over three months. Semi-structured interviews gathered feedback. Assessments included depression (PHQ-9), anxiety (GAD-7), quality of life (SF-12), and major depression risk (predictD algorithm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six FPs from six Spanish cities enrolled 56 non-depressed patients at moderate-to-high risk of depression; 47 (84%) completed follow-up. The app was used for a median of six days (interquartile range: 1\u201330). Both FPs and patients expressed satisfaction, leading to incorporated improvements. After three months, significant reductions in major depression risk and anxiety symptoms were observed, alongside improved mental quality of life. However, no significant changes were found in depressive symptoms or physical quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This pilot study supports the feasibility and acceptability of the e-predictD \u03b2-version, despite lower-than-expected app usability. Health improvements were observed, warranting confirmation in a randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec006\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03990792\" xlink:type=\"simple\">NCT03990792<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0355675","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:21:45Z","timestamp":1789147305000},"page":"e0355675","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toward personalized interventions for preventing depression in primary care: Qualitative and quantitative findings from the e-predictD pilot study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-9090","authenticated-orcid":true,"given":"Patricia","family":"Moreno-Peral","sequence":"first","affiliation":[{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Platform Bionand)","place":["M\u00e1laga, Spain"]},{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"Evaluation and Psychological Treatment, University of Malaga (UMA)","place":["Malaga, Spain"],"department":["Department of Personality"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-3080","authenticated-orcid":true,"given":"Henar","family":"Campos-Pa\u00edno","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Platform Bionand)","place":["M\u00e1laga, Spain"]},{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Rodr\u00edguez-Morej\u00f3n","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Platform Bionand)","place":["M\u00e1laga, Spain"]},{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"Evaluation and Psychological Treatment, University of Malaga (UMA)","place":["Malaga, Spain"],"department":["Department of Personality"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Conejo-Cer\u00f3n","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Platform Bionand)","place":["M\u00e1laga, Spain"]},{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Rodr\u00edguez-Bay\u00f3n","sequence":"additional","affiliation":[{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"Centro de Salud San Jos\u00e9, Distrito Sanitario Ja\u00e9n Norte, Servicio Andaluz de Salud (SAS), Linares","place":["Ja\u00e9n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Ballesta-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"Centro de Salud Federico del Castillo, Distrito Sanitario Ja\u00e9n, Servicio Andaluz de Salud","place":["Ja\u00e9n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Rodr\u00edguez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"\u2018Miguel Armijo\u2019 Health Centre, Castilla and Le\u00f3n Health Service (SACyL)","place":["Salamanca, Spain"]},{"name":"University of Salamanca (USAL)","place":["Salamanca, Spain"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Mendive","sequence":"additional","affiliation":[{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"\u2018La Mina\u2019 Health Centre, Institut Catal\u00e0 de la Salut (ICS)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"L\u00f3pez del 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Universidad de Zaragoza (UNIZAR)","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan de Dios","family":"Luna","sequence":"additional","affiliation":[{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"University of Granada (UGR)","place":["Granada, Spain"],"department":["Department of Statistics and Operational Research"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaya","family":"Tamayo","sequence":"additional","affiliation":[{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"\u2018Miguel Armijo\u2019 Health Centre, Castilla and Le\u00f3n Health Service (SACyL)","place":["Salamanca, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan \u00c1ngel","family":"Bell\u00f3n","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Platform Bionand)","place":["M\u00e1laga, Spain"]},{"name":"Chronicity, Primary Care and Health Promotion Research Network (RICAPPS), ISCIII","place":["Madrid, Spain"]},{"name":"El Palo Health Centre, Andalusian Health Service (SAS)","place":["M\u00e1laga, Spain"]},{"name":"University of M\u00e1laga (UMA)","place":["M\u00e1laga, Spain"],"department":["Department of Public Health and Psychiatry"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"pone.0355675.ref001","unstructured":"World Health Organization. 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