{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:13:39Z","timestamp":1788372819476,"version":"build-2803163510"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the independent and combined associations of the triglyceride-glucose (TyG) index and platelet-to-lymphocyte ratio (PLR) with mental health in Chinese adults, and to evaluate their predictive value using both traditional regression and machine learning approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data from 725 adults at Qilu Hospital of Shandong University were analyzed. Mental health was evaluated using Symptom Checklist-90 (SCL-90). Fasting blood samples were used to calculate the TyG index and PLR. Linear and logistic regressions evaluated associations with overall and domain-specific mental health. The predictive performance of the TyG index and PLR was further evaluated using logistic regression and six machine learning classifiers, based on an 80\/20 train-test split with cross-validation. Multiple performance metrics\u2014including AUC, sensitivity, specificity, and MCC\u2014were reported, and LASSO regression was applied to identify key predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The TyG index was positively associated with the SCL-90 total score, somatization, interpersonal sensitivity, depression, anxiety, and hostility (P\u2009&lt;\u20090.05); PLR showed similar associations and was also associated with phobic anxiety and psychoticism (P\u2009&lt;\u20090.05). Individuals in the high-TyG\/high-PLR group had significantly higher scores across all SCL-90 dimensions (P\u2009&lt;\u20090.05), except for obsessive-compulsive symptoms and paranoid ideation. Among the six machine learning models, LASSO regression demonstrated the best overall predictive performance for mental health problems (AUC\u2009=\u20090.744), showing balanced sensitivity, specificity, F1-score, and MCC. PLR and the TyG index were identified as the strongest positive predictors. Compared with traditional logistic regression, machine learning models showed superior discriminative ability and enabled the assessment of variable importance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The TyG index and PLR are independently and jointly associated with mental health indicators in Chinese adults. Their combination may enhance the ability to identify individuals at elevated risk for mental health problems and could serve as a useful biomarker pair in predictive applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0355937","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:23:32Z","timestamp":1788369812000},"page":"e0355937","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined predictive value of TyG index and PLR for mental health in Chinese adults: A machine learning 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and meta-analysis of longitudinal studies","volume":"150","author":"V Valkanova","year":"2013","journal-title":"J Affect Disord"},{"issue":"4","key":"pone.0355937.ref023","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3343\/alm.2019.39.4.345","article-title":"The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases","volume":"39","author":"AY Gasparyan","year":"2019","journal-title":"Ann Lab Med"},{"issue":"5","key":"pone.0355937.ref024","article-title":"Platelet-to-lymphocyte ratio as a biomarker of systemic inflammation in systemic lupus erythematosus: A meta-analysis and systematic review","volume":"19","author":"YH Lee","year":"2024","journal-title":"PLoS One"},{"issue":"24","key":"pone.0355937.ref025","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15889","article-title":"The association of hematological inflammatory markers and psychological function in COVID-19 patients: A cross-sectional study","volume":"11","author":"Z Khorasanchi","year":"2023","journal-title":"Physiol Rep"},{"issue":"19","key":"pone.0355937.ref026","article-title":"Macrophages, chronic inflammation, and insulin resistance","volume":"11","author":"H Li","year":"2022","journal-title":"Cells"},{"key":"pone.0355937.ref027","doi-asserted-by":"crossref","first-page":"508409","DOI":"10.1155\/2015\/508409","article-title":"Mechanisms Linking Inflammation to Insulin Resistance","volume":"2015","author":"L Chen","year":"2015","journal-title":"Int J Endocrinol"},{"issue":"8942","key":"pone.0355937.ref028","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(95)90066-7","article-title":"Psychoneuroimmunology: interactions between the nervous system and the immune system","volume":"345","author":"R Ader","year":"1995","journal-title":"Lancet"},{"issue":"18","key":"pone.0355937.ref029","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/archinte.1993.00410180039004","article-title":"Stress and the 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Phillips","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"pone.0355937.ref036","doi-asserted-by":"crossref","first-page":"119480","DOI":"10.1016\/j.jad.2025.119480","article-title":"Associations between the triglyceride-glucose index and its combined indices with sleep disorders and the mediating role of depressive symptoms: Results from two nationally representative population studies","volume":"386","author":"P-L Liu","year":"2025","journal-title":"J Affect Disord"},{"key":"pone.0355937.ref037","doi-asserted-by":"crossref","first-page":"1390631","DOI":"10.3389\/fpsyt.2024.1390631","article-title":"Association between the triglyceride glucose index and depression: a meta-analysis","volume":"15","author":"W Wan","year":"2024","journal-title":"Front Psychiatry"},{"key":"pone.0355937.ref038","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jad.2025.05.014","article-title":"Triglyceride-glucose index and its association with depressive symptoms in older adults: a longitudinal analysis","volume":"384","author":"M Forbes","year":"2025","journal-title":"J Affect Disord"},{"issue":"1","key":"pone.0355937.ref039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/neu.2019.17","article-title":"Inflammation, insulin resistance and neuroprogression in depression","volume":"32","author":"BE Leonard","year":"2020","journal-title":"Acta Neuropsychiatr"},{"issue":"2","key":"pone.0355937.ref040","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The Bidirectional Relationship of Depression and Inflammation: Double Trouble","volume":"107","author":"E Beurel","year":"2020","journal-title":"Neuron"},{"issue":"1","key":"pone.0355937.ref041","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/nyas.13217","article-title":"Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus","volume":"1391","author":"JJ 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deficiency","volume":"38","author":"P Sharifan","year":"2023","journal-title":"Int J Geriatr Psychiatry"},{"key":"pone.0355937.ref045","doi-asserted-by":"crossref","first-page":"893097","DOI":"10.3389\/fpsyt.2022.893097","article-title":"Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis","volume":"13","author":"Y Cheng","year":"2022","journal-title":"Front Psychiatry"},{"key":"pone.0355937.ref046","doi-asserted-by":"crossref","first-page":"1671777","DOI":"10.3389\/fpsyt.2025.1671777","article-title":"Association of platelet-to-lymphocyte ratio with depression risk: a systematic review and meta-analysis","volume":"16","author":"M Zhu","year":"2025","journal-title":"Front Psychiatry"},{"issue":"9","key":"pone.0355937.ref047","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20127","article-title":"Association between platelet to lymphocyte ratio and depression and symptom 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Smith","year":"2006","journal-title":"Dialogues Clin Neurosci"},{"issue":"1","key":"pone.0355937.ref054","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1186\/s12889-025-22632-4","article-title":"Temporal relationship between chronic inflammation and insulin resistance and their combined cumulative effect on cancer risk: a longitudinal cohort study","volume":"25","author":"X Zheng","year":"2025","journal-title":"BMC Public Health"},{"issue":"1","key":"pone.0355937.ref055","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1186\/s12885-022-09752-5","article-title":"Prognostic importance of systemic inflammation and insulin resistance in patients with cancer: a prospective multicenter study","volume":"22","author":"G-T Ruan","year":"2022","journal-title":"BMC Cancer"},{"issue":"1","key":"pone.0355937.ref056","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1038\/s41598-023-31450-w","article-title":"Comprehensive prognostic effects of systemic inflammation and 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