{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:26:09Z","timestamp":1786991169601,"version":"build-2736575974"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000194","name":"Nova Scotia Health Research Fund","doi-asserted-by":"crossref","award":["1027848"],"award-info":[{"award-number":["1027848"]}],"id":[{"id":"10.13039\/501100000194","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000194","name":"Nova Scotia Health Research Fund","doi-asserted-by":"crossref","award":["1027848"],"award-info":[{"award-number":["1027848"]}],"id":[{"id":"10.13039\/501100000194","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spatial neglect is a common attentional condition post-stroke linked to poor rehabilitation outcomes. Prism adaptation, though a promising intervention, is not yet widely used clinically due to various barriers to its implementation, including limited accessibility, the repetitive nature of the therapy, and the need for specialized equipment. This protocol aims to examine the effectiveness, feasibility, and acceptability of an engaging, mobile, computerized prism adaptation procedure (Peg-the-Mole) for treating spatial neglect in stroke inpatient and outpatient community settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods\/design<\/jats:title>\n                    <jats:p>The present study uses a longitudinal, double-blind, quasi-randomized, controlled design. Forty-two individuals with right-hemisphere stroke experiencing mild to severe symptoms of neglect will be randomized into two groups: Use of Peg-the-Mole with 15-degree rightward-deviating prism goggles (intervention) or use of Peg-the-Mole with 5-degree rightward-deviating prism goggles (active control). Participants will complete 10 treatment sessions over 2 weeks, engaging with the Peg-the-Mole procedure for 15 minutes daily. Blinded assessments will take place immediately before and after treatment, as well as at one-month follow-up. The primary outcome measure will be the Star Cancellation conventional subtest of the Behavioural Inattention Test. Secondary outcomes will include additional conventional and behavioural subtests of the Behavioural Inattention Test, one subtest of the Eschenbeck Standardized Activities of Daily Living battery, the caregiver- and self-reported forms of the Halifax Neglect Impact Scale, data measuring feasibility and acceptability, prism adaptation after-effects, the Hospital Anxiety and Depression Scale, and the Fatigue Severity Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The Peg-the-Mole procedure has the potential to improve patient recovery and quality of life after stroke due to its gamified, portable features that promote treatment accessibility and adherence. Results from this study will help determine if the treatment can be implemented successfully in inpatient and community settings to improve neglect symptoms and daily living.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Clinicaltrials.gov, Identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05595668\" xlink:type=\"simple\">NCT05595668<\/jats:ext-link>\n                      ; registered October 27, 2022.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0356055","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:26:38Z","timestamp":1786987598000},"page":"e0356055","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["EMPATH protocol: Randomized, double-blind trial of an Engaging and Mobile Prism Adaptation Treatment for spatial neglect in Home and rehabilitation settings"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-3067","authenticated-orcid":true,"given":"Catrina","family":"MacPhee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Eskes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Mackinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Sophie","family":"Champod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"pone.0356055.ref001","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/oso\/9780195081237.003.0012","article-title":"Neglect and Related Disorders","author":"KM Heilman","year":"1993","journal-title":"Clinical Neuropsychology"},{"issue":"2","key":"pone.0356055.ref002","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ana.410050210","article-title":"Mechanisms underlying hemispatial neglect","volume":"5","author":"KM Heilman","year":"1979","journal-title":"Ann Neurol"},{"key":"pone.0356055.ref003","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000494956","article-title":"Hemineglect and attentional dysfunction","volume":"44","author":"KG Langer","year":"2019","journal-title":"Front Neurol Neurosci"},{"issue":"4","key":"pone.0356055.ref004","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.rehab.2019.05.006","article-title":"Impact of visuospatial neglect post-stroke on daily activities, participation and informal caregiver burden: a systematic review","volume":"63","author":"MS Bosma","year":"2020","journal-title":"Ann Phys Rehabil Med"},{"issue":"5","key":"pone.0356055.ref005","doi-asserted-by":"crossref","first-page":"101459","DOI":"10.1016\/j.rehab.2020.10.010","article-title":"Prevalence of spatial neglect post-stroke: a systematic review","volume":"64","author":"E Esposito","year":"2021","journal-title":"Ann Phys Rehabil Med"},{"issue":"5","key":"pone.0356055.ref006","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1212\/01.WNL.0000113730.73031.F4","article-title":"Hemispatial neglect","volume":"62","author":"LJ Buxbaum","year":"2004","journal-title":"Neurology"},{"issue":"8","key":"pone.0356055.ref007","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cortex.2012.11.006","article-title":"Time course of visuospatial neglect early after stroke: a longitudinal cohort study","volume":"49","author":"TCW Nijboer","year":"2013","journal-title":"Cortex"},{"issue":"9","key":"pone.0356055.ref008","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1161\/STROKEAHA.124.046760","article-title":"Recovery of visuospatial neglect with standard treatment: a systematic review and meta-analysis","volume":"55","author":"MJ Overman","year":"2024","journal-title":"Stroke"},{"issue":"1","key":"pone.0356055.ref009","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/10749357.2016.1186373","article-title":"Informal caregivers\u2019 burden and stress in caring for stroke survivors with spatial neglect: an exploratory mixed-method study","volume":"24","author":"P Chen","year":"2017","journal-title":"Top Stroke Rehabil"},{"issue":"3","key":"pone.0356055.ref010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.5853\/jos.2016.01144","article-title":"Post-stroke mood and emotional disturbances: pharmacological therapy based on mechanisms","volume":"18","author":"JS Kim","year":"2016","journal-title":"J Stroke"},{"key":"pone.0356055.ref011","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1161\/STROKEAHA.121.035499","article-title":"Depression, anxiety, and suicide after stroke: a narrative review of the best available evidence","volume":"53","author":"HYY Chun","year":"2022","journal-title":"Stroke"},{"issue":"12","key":"pone.0356055.ref012","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/brainsci9120374","article-title":"Spatial neglect in stroke: identification, disease process and association with outcome during inpatient rehabilitation","volume":"9","author":"U Hammerbeck","year":"2019","journal-title":"Brain Sci"},{"issue":"8","key":"pone.0356055.ref013","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.apmr.2015.03.019","article-title":"Impact of spatial neglect on stroke rehabilitation: evidence from the setting of an inpatient rehabilitation facility","volume":"96","author":"P Chen","year":"2015","journal-title":"Arch Phys Med Rehabil"},{"issue":"5","key":"pone.0356055.ref014","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/PHM.0000000000001710","article-title":"How we assess spatial neglect matters: prevalence of spatial neglect as measured by the Catherine Bergego Scale and impact on rehabilitation outcomes","volume":"100","author":"RW Gillen","year":"2021","journal-title":"Am J Phys Med Rehabil"},{"key":"pone.0356055.ref015","first-page":"347","article-title":"Rehabilitation of spatial neglect.","volume-title":"Handbook of Clinical Neurology","author":"AR Riestra","year":"2013"},{"issue":"3","key":"pone.0356055.ref016","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.rehab.2016.10.006","article-title":"Rehabilitation of unilateral neglect: evidence-based medicine","volume":"60","author":"P Azouvi","year":"2017","journal-title":"Ann Phys Rehabil Med"},{"key":"pone.0356055.ref017","doi-asserted-by":"crossref","first-page":"1539887","DOI":"10.3389\/fresc.2025.1539887","article-title":"Does prism adaptation treatment reduce spatial neglect and improve function?","volume":"6","author":"P Chen","year":"2025","journal-title":"Front Rehabil Sci"},{"issue":"25","key":"pone.0356055.ref018","article-title":"Update on the clinical approach to spatial neglect","volume":"19","author":"AM Barrett","year":"2019","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"7","key":"pone.0356055.ref019","article-title":"Non-pharmacological interventions for spatial neglect or inattention following stroke and other non-progressive brain injury","volume":"7","author":"V Longley","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"pone.0356055.ref020","first-page":"113","article-title":"Examining anosognosia of neglect","volume":"38","author":"ES Grattan","year":"2018","journal-title":"OTJR (Thorofare N J)"},{"issue":"5","key":"pone.0356055.ref021","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/ene.12413","article-title":"Anosognosia, neglect and quality of life of right hemisphere stroke survivors","volume":"21","author":"C-Y Dai","year":"2014","journal-title":"Eur J Neurol"},{"issue":"8","key":"pone.0356055.ref022","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1177\/1545968311407516","article-title":"Prism adaptation therapy enhances rehabilitation of stroke patients with unilateral spatial neglect: a randomized, controlled trial","volume":"25","author":"K Mizuno","year":"2011","journal-title":"Neurorehabil Neural Repair"},{"issue":"3","key":"pone.0356055.ref023","first-page":"100130","article-title":"Prism adaptation treatment improves inpatient rehabilitation outcome in individuals with spatial neglect: a retrospective matched control study","volume":"3","author":"P Chen","year":"2021","journal-title":"Arch Rehabil Res Clin Transl"},{"issue":"5","key":"pone.0356055.ref024","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/23279095.2015.1038386","article-title":"Efficacy of visual-scanning training and prism adaptation for neglect rehabilitation","volume":"23","author":"S Spaccavento","year":"2016","journal-title":"Appl Neuropsychol Adult"},{"issue":"10","key":"pone.0356055.ref025","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1080\/09602011.2022.2131582","article-title":"Clinical and demographic predictors of unilateral spatial neglect recovery after prism therapy among stroke survivors in the sub-acute phase of recovery","volume":"33","author":"CI Umeonwuka","year":"2023","journal-title":"Neuropsychol Rehabil"},{"issue":"10","key":"pone.0356055.ref026","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nrneurol.2012.170","article-title":"Prism adaptation for spatial neglect after stroke: translational practice gaps","volume":"8","author":"AM Barrett","year":"2012","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"pone.0356055.ref027","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1037\/0096-1523.22.2.379","article-title":"Adaptive spatial alignment and strategic perceptual-motor control","volume":"22","author":"GM Redding","year":"1996","journal-title":"J Exp Psychol Hum Percept Perform"},{"key":"pone.0356055.ref028","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/00222890209601935","article-title":"Strategie calibration and spatial alignment: a model from prism adaptation","volume":"34","author":"GM Redding","year":"2002","journal-title":"J Motor Behav"},{"issue":"1","key":"pone.0356055.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropsychologia.2005.04.009","article-title":"Prism adaptation and unilateral neglect: review and analysis","volume":"44","author":"GM Redding","year":"2006","journal-title":"Neuropsychologia"},{"issue":"3","key":"pone.0356055.ref030","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neubiorev.2004.12.004","article-title":"Applications of prism adaptation: a tutorial in theory and method","volume":"29","author":"GM Redding","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"pone.0356055.ref031","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/09602010903040683","article-title":"A single blinded randomised controlled pilot trial of prism adaptation for improving self-care in stroke patients with neglect","volume":"20","author":"AJ Turton","year":"2010","journal-title":"Neuropsychol Rehabil"},{"issue":"2","key":"pone.0356055.ref032","first-page":"197","article-title":"Clinical application of prismatic lenses in the rehabilitation of neglect patients. A randomized controlled trial","volume":"48","author":"M Mancuso","year":"2012","journal-title":"Eur J Phys Rehabil Med"},{"key":"pone.0356055.ref033","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fnhum.2015.00243","article-title":"Prism adaptation and spatial neglect: the need for dose-finding studies","volume":"9","author":"KM Goedert","year":"2015","journal-title":"Front Hum Neurosci"},{"issue":"4","key":"pone.0356055.ref034","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/STROKEAHA.108.530485","article-title":"Effectiveness of prism adaptation in neglect rehabilitation: a controlled trial study","volume":"40","author":"A Serino","year":"2009","journal-title":"Stroke"},{"key":"pone.0356055.ref035","first-page":"7","article-title":"Prismatic adaptation in the rehabilitation of neglect patients: does the specific procedure matter?","author":"A Facchin","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"pone.0356055.ref036","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneumeth.2014.05.023","article-title":"Development of a new computerized prism adaptation procedure for visuo-spatial neglect","volume":"235","author":"AS Champod","year":"2014","journal-title":"J Neurosci Methods"},{"key":"pone.0356055.ref037","doi-asserted-by":"crossref","first-page":"803312","DOI":"10.3389\/fneur.2022.803312","article-title":"Prism adaptation treatment of spatial neglect: feasibility during inpatient rehabilitation and identification of patients most likely to benefit","volume":"13","author":"RW Gillen","year":"2022","journal-title":"Front Neurol"},{"issue":"4","key":"pone.0356055.ref038","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/09602011.2016.1182032","article-title":"The effects of prism adaptation on daily life activities in patients with visuospatial neglect: a systematic review","volume":"28","author":"AS Champod","year":"2018","journal-title":"Neuropsychol Rehabil"},{"key":"pone.0356055.ref039","unstructured":"MacPhee C, Champod AS, Smith L. Age-related differences in prism adaptation effects across the adult lifespan. Neurorehabilitation and Neural Repair. pp. 3S\u201355S."},{"issue":"1","key":"pone.0356055.ref040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/NRE-210028","article-title":"Can prism adaptation effects generalize to wheelchair maneuvering?","volume":"49","author":"LE Wyatt","year":"2021","journal-title":"NeuroRehabilitation"},{"key":"pone.0356055.ref041","unstructured":"Boyce J. Implementing prism adaptation treatment after stroke (IPATS) clinical trial."},{"issue":"2","key":"pone.0356055.ref042","first-page":"98","article-title":"Development of a behavioral test of visuospatial neglect","volume":"68","author":"B Wilson","year":"1987","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"pone.0356055.ref043","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0003-9993(99)90116-8","article-title":"Fatigue after stroke","volume":"80","author":"JL Ingles","year":"1999","journal-title":"Arch Phys Med Rehabil"},{"key":"pone.0356055.ref044","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1176\/appi.ajp.2015.15030363","article-title":"Post-Stroke depression: a review","volume":"173","author":"RG Robinson","year":"2016","journal-title":"Am J Psychiatry"},{"issue":"3","key":"pone.0356055.ref045","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-158-3-201302050-00583","article-title":"SPIRIT 2013 statement: defining standard protocol items for clinical trials","volume":"158","author":"A-W Chan","year":"2013","journal-title":"Ann Intern Med"},{"issue":"1","key":"pone.0356055.ref046","article-title":"Simulation-based power analysis for factorial analysis of variance designs","volume":"4","author":"D Lakens","year":"2021","journal-title":"Adv Methods Pract Psychol Sci"},{"key":"pone.0356055.ref047","doi-asserted-by":"crossref","first-page":"108566","DOI":"10.1016\/j.neuropsychologia.2023.108566","article-title":"No short-term treatment effect of prism adaptation for spatial neglect: An inclusive meta-analysis","volume":"189","author":"O Sz\u00e9kely","year":"2023","journal-title":"Neuropsychologia"},{"issue":"1","key":"pone.0356055.ref048","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245425","article-title":"Prism adaptation treatment to address spatial neglect in an intensive rehabilitation program: A randomized pilot and feasibility trial","volume":"16","author":"T Vilimovsky","year":"2021","journal-title":"PLoS One"},{"issue":"6","key":"pone.0356055.ref049","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/DBP.0b013e3181900224","article-title":"An introduction to sample size and power","volume":"29","author":"BA Bernstein","year":"2008","journal-title":"J Dev Behav Pediatr"},{"key":"pone.0356055.ref050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1741-7015-8-17","article-title":"Current sample size conventions: flaws, harms, and alternatives","volume":"8","author":"P Bacchetti","year":"2010","journal-title":"BMC Med"},{"issue":"6","key":"pone.0356055.ref051","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3758\/s13423-021-01970-5","article-title":"When randomisation is not good enough: Matching groups in intervention studies","volume":"28","author":"F Sella","year":"2021","journal-title":"Psychon Bull Rev"},{"issue":"9","key":"pone.0356055.ref052","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1161\/STROKEAHA.113.001847","article-title":"The Stroke Impact Scale: validation in a UK setting and development of a SIS short form and SIS index","volume":"44","author":"C Jenkinson","year":"2013","journal-title":"Stroke"},{"issue":"4","key":"pone.0356055.ref053","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"ZS Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"pone.0356055.ref054","volume-title":"Contributions to neuropsychological assessment","author":"A Benton","year":"1983"},{"issue":"4","key":"pone.0356055.ref055","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1076\/jcen.20.4.457.1470","article-title":"Normative data for equivalent, parallel forms of the Judgment of Line Orientation Test","volume":"20","author":"JL Woodard","year":"1998","journal-title":"J Clin Exp Neuropsychol"},{"key":"pone.0356055.ref056","volume-title":"WMS-R: Wechsler Memory Scale--Revised: Manual","author":"D Wechsler","year":"1987"},{"issue":"7","key":"pone.0356055.ref057","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2466\/PMS.8.7.271-276","article-title":"Validity of the trail making test as an indicator of organic brain damage","volume":"8","author":"RM Reitan","year":"1958","journal-title":"Perceptual Motor Skills"},{"issue":"3","key":"pone.0356055.ref058","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1006\/brcg.1998.1003","article-title":"Perceptual and response bias in unilateral neglect: two modified versions of the milner landmark task","volume":"37","author":"E Bisiach","year":"1998","journal-title":"Brain Cogn"},{"key":"pone.0356055.ref059","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/brain\/123.8.1643","article-title":"Distinguishing sensory and motor biases in parietal and frontal neglect","author":"M Husain","year":"2000","journal-title":"Brain"},{"issue":"3","key":"pone.0356055.ref060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/NRE-2000-14303","article-title":"Evaluation of a test battery for hemineglect in elderly stroke patients for use by therapists in clinical practice","volume":"14","author":"MJ Bailey","year":"2000","journal-title":"NeuroRehabilitation"},{"issue":"4","key":"pone.0356055.ref061","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/09602010343000282","article-title":"Test\u2013retest stability of three tests for unilateral visual neglect in patients with stroke: Star Cancellation, Line Bisection, and the Baking Tray Task","volume":"14","author":"MJ Bailey","year":"2004","journal-title":"Neuropsychol Rehabil"},{"issue":"3","key":"pone.0356055.ref062","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/09602019308401439","article-title":"Screening tests for visual neglect following stroke","volume":"3","author":"NV Marsh","year":"1993","journal-title":"Neuropsychol Rehabil"},{"issue":"12","key":"pone.0356055.ref063","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1016\/j.neuropsychologia.2010.07.034","article-title":"Testing for neglect in right-hemispheric stroke patients using a new assessment battery based upon standardized activities of daily living (ADL)","volume":"48","author":"P Eschenbeck","year":"2010","journal-title":"Neuropsychologia"},{"issue":"6","key":"pone.0356055.ref064","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"AS Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"issue":"10","key":"pone.0356055.ref065","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archneur.1989.00520460115022","article-title":"The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus","volume":"46","author":"LB Krupp","year":"1989","journal-title":"Arch Neurol"},{"issue":"1","key":"pone.0356055.ref066","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1037\/0003-066X.55.1.68","article-title":"Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being","volume":"55","author":"RM Ryan","year":"2000","journal-title":"Am Psychol"},{"key":"pone.0356055.ref067","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2307\/271063","article-title":"Bayesian model selection in social research","volume":"25","author":"AE Raftery","year":"1995","journal-title":"Sociol Methodol"},{"key":"pone.0356055.ref068","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1146\/annurev.psych.58.110405.085530","article-title":"Missing data analysis: making it work in the real world","volume":"60","author":"JW Graham","year":"2009","journal-title":"Annu Rev Psychol"},{"key":"pone.0356055.ref069","author":"M Quartagno"},{"key":"pone.0356055.ref070","author":"S Grund"},{"issue":"1","key":"pone.0356055.ref071","doi-asserted-by":"crossref","DOI":"10.2196\/25251","article-title":"Exploring barriers to and enablers of the adoption of information and communication technology for the care of older adults with chronic diseases: scoping review","volume":"5","author":"SB Zaman","year":"2022","journal-title":"JMIR Aging"},{"issue":"1","key":"pone.0356055.ref072","doi-asserted-by":"crossref","first-page":"01","DOI":"10.31579\/2578-8868\/359","article-title":"Integrating physical therapy and exercise in mental health: a novel framework for suicide prevention and depression management","volume":"17","author":"J Kanani","year":"2025","journal-title":"JNNS"},{"key":"pone.0356055.ref073","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cortex.2018.09.001","article-title":"A home-based prism adaptation training for neglect patients","volume":"122","author":"P Fortis","year":"2020","journal-title":"Cortex"},{"key":"pone.0356055.ref074","doi-asserted-by":"crossref","first-page":"105248","DOI":"10.1016\/j.neubiorev.2023.105248","article-title":"Virtual reality rehabilitation for unilateral spatial neglect: a systematic review of immersive, semi-immersive and non-immersive techniques","volume":"152","author":"A Salatino","year":"2023","journal-title":"Neurosci Biobehav Rev"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0356055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:26:48Z","timestamp":1786987608000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0356055"}},"subtitle":[],"editor":[{"given":"Maheshkumar","family":"Baladaniya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":74,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0356055","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}