{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:31:23Z","timestamp":1793730683618,"version":"4.6.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate circulating C1q\/TNF-related protein-1 (CTRP-1) levels in women with polycystic ovary syndrome (PCOS) and evaluate its potential association with metabolic and reproductive features of the syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cross-sectional case\u2013control study was conducted between October 2021 and March 2022 including 96 women (48 with PCOS and 48 controls) aged 15\u201340 years. PCOS was diagnosed according to the 2003 Rotterdam criteria. Anthropometric measurements and fasting venous blood samples were obtained during the early follicular phase. Serum CTRP-1 levels were measured using enzyme-linked immunosorbent assay (ELISA). Metabolic and hormonal parameters, including HOMA-IR, AMH, and androgen levels, were analyzed. Receiver operating characteristic (ROC) analysis and analysis of covariance (ANCOVA) adjusted for age and body mass index (BMI) were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum CTRP-1 levels were significantly higher in women with PCOS compared with controls (54.9\u2009\u00b1\u20095.2 vs. 26.6\u2009\u00b1\u20094.8 ng\/mL, p\u2009&lt;\u20090.001). CTRP-1 concentrations were associated with several metabolic and hormonal parameters, including BMI, fasting insulin, triglyceride levels, HDL cholesterol, and AMH. ROC curve analysis demonstrated excellent discriminatory ability within this cohort, although these findings should be interpreted cautiously given the relatively small sample size and case\u2013control design. In multivariable analysis adjusting for age and BMI, CTRP-1 remained independently associated with PCOS (\u03b2\u2009=\u200928.97, p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circulating CTRP-1 levels are elevated in women with PCOS and appear to be associated with both metabolic and reproductive characteristics of the syndrome. CTRP-1 may represent a potential biomarker related to metabolic dysregulation in PCOS; however, larger prospective and multicenter studies are required to validate its clinical and diagnostic utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0356461","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:29:42Z","timestamp":1787678982000},"page":"e0356461","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating CTRP-1 levels are elevated in women with polycystic ovary syndrome: A case\u2013control study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-1516","authenticated-orcid":true,"given":"Cavide","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"\u015eayir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feride","family":"\u00d6\u00e7ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"\u00d6zt\u00fcrk Atan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5629-2036","authenticated-orcid":true,"given":"Melike Sevde","family":"Harmanc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Cem","family":"S\u00fcrecek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacer Cavidan","family":"G\u00fclerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"1","key":"pone.0356461.ref001","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","journal-title":"Hum Reprod"},{"issue":"9588","key":"pone.0356461.ref002","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"RJ Norman","year":"2007","journal-title":"The 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