{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:08:35Z","timestamp":1789754915398,"version":"4.0.1"},"reference-count":118,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001317","name":"Swansea University","doi-asserted-by":"publisher","award":["RIO 034-20"],"award-info":[{"award-number":["RIO 034-20"]}],"id":[{"id":"10.13039\/501100001317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The avoidable harm due to incomplete monitoring of repeat prescriptions in primary care has been known for decades, but prevention has proved difficult. We aimed to test the ability of the Adverse Drug Reaction (ADRe) Profile to identify and address clinical problems for patients aged \u226565 prescribed &gt;4 long-term medicines, living in their own homes, and managed in primary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A pragmatic cluster-randomized controlled trial was undertaken in 6 primary care practices in South-West Wales, alongside a process evaluation. In addition to usual care, patients in the intervention arm completed the ADRe Profile, which was then shared with the practice pharmacist. Patients completed a second ADRe Profile with the nurse researcher 20 weeks later. The control arm received usual care. Information on patients\u2019 clinical problems and prescriptions was extracted from practice medical records before and after the intervention and analysed using multilevel generalised linear mixed models (GLMM), including practice as a random intercept, and accounting for trial arm, age, deprivation and co-morbidities. Symptoms recorded on the first and second Profiles were compared. Resolution of clinical problems was described, and participants\u2019 perspectives sought.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We recruited one general practice group, comprising six practices, and 60 patients. Three patients were lost to the study. Intervention arm patients were more likely to have more than one problem addressed than control arm patients (22\/27[82%] vs. 11\/30[35%], adjusted odds ratio [aOR] 7.48, 95% confidence interval [CI] 1.99-28.10). All intervention arm patients either benefited or expected to benefit following referrals. For two patients, the intervention proved critical: detection of B12 deficiency in a patient using metformin and flecainide de-prescribing. Fewer patients reported pain by the study\u2019s end (16\/27 vs 24\/27). All patients were grateful for ADRe, but clinicians had reservations concerning staff time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The ADRe Profile benefited patients by reducing risk of suboptimal prescribing and iatrogenic harm. The project is registered with the Clinicaltrials.gov as NCT04663360 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT04663360\" xlink:type=\"simple\">https:\/\/clinicaltrials.gov\/study\/NCT04663360<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0356480","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:27:11Z","timestamp":1789752431000},"page":"e0356480","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cA better system\u201d \u2013 managing the adverse effects of prescribed medicines: Cluster-randomised controlled trial and process evaluation of the ADRe Profile in primary care"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-0272","authenticated-orcid":true,"given":"Vera","family":"Logan","sequence":"first","affiliation":[{"name":"Health and Life Science, Swansea University","place":["Swansea, Wales, United Kingdom"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Conboy","sequence":"additional","affiliation":[{"name":"Health and Life Science, Swansea University","place":["Swansea, Wales, United Kingdom"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-8661","authenticated-orcid":true,"given":"Neil","family":"Carter","sequence":"additional","affiliation":[{"name":"Health and Life Science, Swansea University","place":["Swansea, Wales, United Kingdom"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-7763","authenticated-orcid":true,"given":"David","family":"Hughes","sequence":"additional","affiliation":[{"name":"Health and Life Science, Swansea University","place":["Swansea, Wales, United Kingdom"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Turner","sequence":"additional","affiliation":[{"name":"Health and Life Science, Swansea University","place":["Swansea, Wales, United Kingdom"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Watkins","sequence":"additional","affiliation":[{"name":"Health and Life Science, Swansea University","place":["Swansea, Wales, United Kingdom"],"department":["Faculty of 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