{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:03:19Z","timestamp":1789581799631,"version":"build-2803163510"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002476","name":"Eulji University","doi-asserted-by":"publisher","award":["EJRG-25-10"],"award-info":[{"award-number":["EJRG-25-10"]}],"id":[{"id":"10.13039\/501100002476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alcohol consumption is a significant social medium in South Korea, yet alcohol use disorders (AUD) impose a substantial public health burden. This study aimed to analyze sex-specific clinico-demographic characteristics, comorbidity patterns, and factors affecting the length of stay (LOS) among patients hospitalized for alcohol-induced mental and behavioral disorders using a nationally representative database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional study utilized data from the Korea National Hospital Discharge In-Depth Injury Survey (KNHDIS) from 2014 to 2023. After applying sampling weights to account for the complex survey design, a total of 201,572 patients were included in the analysis. Differences in general characteristics were tested using the Rao-Scott chi-square test, and factors influencing log-transformed LOS were identified through multiple linear regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Demographic Profile: Male patients were most prevalent in their 50s (36.6%), whereas female patients showed a younger age distribution, peaking in their 40s (31.1%). Comorbidity Patterns: Men had a higher prevalence of cardiovascular disease (30.0%) and diabetes (20.2%). Conversely, women exhibited significantly higher rates of comorbid mental disorders (31.5%) and injuries (19.8%). Predictors of LOS: Comorbid mental disorders were the strongest predictors of prolonged LOS in both sexes. However, injuries and neurological diseases significantly extended LOS only in men, showing no significant impact in women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Comorbidity patterns and medical resource utilization patterns among patients with alcohol use disorder differ markedly by sex. Therefore, alcohol addiction management policies and clinical interventions require sex-tailored approaches, particularly emphasizing the urgent establishment of multidisciplinary integrated treatment systems for cases with comorbid mental health disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0356598","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:28:51Z","timestamp":1789579731000},"page":"e0356598","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between alcohol-Induced mental and behavioral disorders and comorbidities: Evidence from the Korea National Hospital Discharge In-depth Injury survey data"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5094-6107","authenticated-orcid":true,"given":"Jieun","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2919-5943","authenticated-orcid":true,"given":"Seri","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunkyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-386X","authenticated-orcid":true,"given":"Kyunghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"4","key":"pone.0356598.ref001","article-title":"The prevalence of and factors associated with high-risk alcohol consumption in Korean adults: The 2009-2011 Korea National Health and Nutrition Examination Survey","volume":"12","author":"JW Hong","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"pone.0356598.ref002","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1186\/s12889-024-19321-z","article-title":"Trends in alcohol use and alcoholic liver disease in South Korea: a nationwide cohort study","volume":"24","author":"J-J Yoo","year":"2024","journal-title":"BMC Public Health"},{"issue":"10152","key":"pone.0356598.ref003","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(18)31310-2","article-title":"Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"392","author":"GBD 2016 Alcohol Collaborators","year":"2018","journal-title":"Lancet"},{"issue":"20","key":"pone.0356598.ref004","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1001\/jama.2025.2726","article-title":"Sex-based differences in binge and heavy drinking among US adults","volume":"333","author":"B Shuey","year":"2025","journal-title":"JAMA"},{"key":"pone.0356598.ref005","volume-title":"Risk and high-risk drinking\u2013attributable disease costs and addiction- and suicide-related mortality costs","author":"YH Jung","year":"2016"},{"issue":"2","key":"pone.0356598.ref006","doi-asserted-by":"crossref","first-page":"01","DOI":"10.35946\/arcr.v40.2.01","article-title":"Gender differences in the epidemiology of alcohol use and related harms in the United States","volume":"40","author":"AM White","year":"2020","journal-title":"Alcohol Res"},{"issue":"3","key":"pone.0356598.ref007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4082\/kjfm.23.0024","article-title":"Current status of korean alcohol drinking in accordance with the korean alcohol guidelines for moderate drinking based on facial flushing","volume":"44","author":"S Lee","year":"2023","journal-title":"Korean J Fam Med"},{"key":"pone.0356598.ref008","unstructured":"Korea Disease Control and Prevention Agency. 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