{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:03:22Z","timestamp":1790100202148,"version":"4.0.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Endometriosis is a chronic gynecological disorder characterized by persistent pain and impaired quality of life, with limited effective treatment options. Emerging evidence indicates that cannabinoids may provide analgesic and symptom-relieving effects in chronic pain conditions. This prospective single-center cohort study investigated the effects of standardized oral cannabis extracts (cannabinoid-based medicinal products, CBMPs) on pain and quality of life in women with endometriosis. Thirty premenopausal women aged 18\u201345 years with confirmed endometriosis and chronic pelvic pain were enrolled; 27 completed the 3-month treatment period. Participants received oral CBMPs containing a balanced THC: CBD ratio. Pain intensity, frequency of pain episodes, analgesic use, fatigue, anxiety, central sensitization, disability, and quality of life were assessed using validated questionnaires (VAS, EHP-30, PDI, CFS, GAD-7, CSI). Significant improvements were observed after one month of treatment, with continued benefit over three months. Pain intensity decreased markedly (p\u2009=\u20090.0004), accompanied by reductions in the number of pain days and analgesic use, including both NSAIDs (e.g., ibuprofen, diclofenac) and opioid analgesics (e.g., tramadol, tilidin, oxycodone) (p\u2009&lt;\u20090.001). Fatigue (p\u2009=\u20090.0013), anxiety (p\u2009&lt;\u20090.0001), central sensitization (p\u2009&lt;\u20090.0001), disability (p\u2009&lt;\u20090.0001), and overall quality of life (EHP-30) improved significantly. Treatment was well tolerated; side effects were predominantly mild (severity score 1 on a 0\u20133 scale) and transient, occurring mainly during the titration phase and declining thereafter. Although limited by its single-center design, lack of placebo control, and short follow-up, this study provides preliminary evidence that oral CBMPs may represent a safe and effective adjunct therapy for managing pain and related symptoms in women with endometriosis. Larger randomized controlled trials are warranted to confirm these findings and establish optimal dosing strategies.<\/jats:p>","DOI":"10.1371\/journal.pone.0356768","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:24:07Z","timestamp":1790097847000},"page":"e0356768","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the impact of cannabinoid extracts on chronic pain and quality of life in endometriosis patients \u2013 a pilot study"],"prefix":"10.1371","volume":"21","author":[{"given":"Janosch W.","family":"Kratz","sequence":"first","affiliation":[{"name":"Endometriosis Research Centre Charit\u00e9","place":["Berlin, Germany"],"department":["Department of Gynecology Charit\u00e9 with Centre of Oncological Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Voltolini","family":"Velho","sequence":"additional","affiliation":[{"name":"Endometriosis Research Centre Charit\u00e9","place":["Berlin, Germany"],"department":["Department of Gynecology Charit\u00e9 with Centre of Oncological Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Bock","sequence":"additional","affiliation":[{"name":"Endometriosis Research Centre Charit\u00e9","place":["Berlin, Germany"],"department":["Department of Gynecology Charit\u00e9 with Centre of Oncological Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalid","family":"Sehouli","sequence":"additional","affiliation":[{"name":"Endometriosis Research Centre Charit\u00e9","place":["Berlin, Germany"],"department":["Department of Gynecology Charit\u00e9 with Centre of Oncological Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0048","authenticated-orcid":true,"given":"Sylvia","family":"Mechsner","sequence":"additional","affiliation":[{"name":"Endometriosis Research Centre Charit\u00e9","place":["Berlin, Germany"],"department":["Department of Gynecology Charit\u00e9 with Centre of Oncological Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"2","key":"pone.0356768.ref001","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11020467","article-title":"Endometriosis, an Ongoing Pain-Step-by-Step treatment","volume":"11","author":"S Mechsner","year":"2022","journal-title":"J Clin Med"},{"key":"pone.0356768.ref002","article-title":"\u201cEndometriosis affects an estimated 1 to 10 of women of childbearing age\u201d: How close are we to the truth? 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