{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:19:05Z","timestamp":1787941145006,"version":"build-2784847793"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"smarter","award":["772787"],"award-info":[{"award-number":["772787"]}]},{"DOI":"10.13039\/100016307","name":"APIS-GENE","doi-asserted-by":"publisher","award":["ActiveGoat"],"award-info":[{"award-number":["ActiveGoat"]}],"id":[{"id":"10.13039\/100016307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016307","name":"APIS-GENE","doi-asserted-by":"publisher","award":["Resilait"],"award-info":[{"award-number":["Resilait"]}],"id":[{"id":"10.13039\/100016307","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>The present study aims to explore the phenotypic variability of the inflammatory response to a lipopolysaccharide (LPS) challenge in goats and compare the reaction between two lines divergently selected for functional longevity. Hyper-selection based on functional longevity successfully created two groups of goats with different lifespans (High_LGV and Low_LGV). Primiparous goats were injected intravenously with LPS to trigger an inflammatory response, with a total of 83 goats, including 42 High_LGV and 41 Low_LGV goats. Blood was sampled 12 times at \u221272, 0 (injection), 2, 4, 6, 8, 10, 12, 24, 48, 72, and 144 hours. Baseline cytokine concentrations (average of hours \u221272 and 0) showed no significant differences between longevity lines for any of the 14 measured cytokines. Among the six cytokines that responded to the LPS challenge (IFN-\u03b3, IL4, IL-6, IL-10, MIP1\u03b1, and TNF\u03b1), three showed significant differences between longevity lines in their temporal response profiles. Low_LGV goats exhibited stronger acute inflammatory responses with greater IL-6 and IFN-\u03b3 concentrations during the early hours post-challenge, while High_LGV goats showed elevated MIP1\u03b1 concentrations during the resolution phase. In parallel, whole blood was stimulated for 24 hours with LPS on a total of 157 goats for ex vivo assessment of the blood response. The IL-6 concentration measured in the whole blood assay showed a moderate correlation with the in vivo response and revealed no difference between the longevity lines. These results suggest that a stronger acute inflammatory response, characterised by elevated pro-inflammatory cytokine production, may be detrimental to functional longevity in dairy goats, possibly through increased tissue damage and impaired recovery following inflammatory challenges.<\/jats:p>","DOI":"10.1371\/journal.pone.0356779","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:40:16Z","timestamp":1787938816000},"page":"e0356779","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of longevity genotype on acute phase response to a lipopolysaccharide challenge in dairy goats"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-3194","authenticated-orcid":true,"given":"Marie","family":"Ithurbide","sequence":"first","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE","place":["Castanet-Tolosan, France"]},{"name":"GABI, INRAE, AgroParisTech, Universit\u00e9 Paris-Saclay","place":["Jouy-en-Josas, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rupp","sequence":"additional","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE","place":["Castanet-Tolosan, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fassier","sequence":"additional","affiliation":[{"name":"Domaine de Bourges, INRAE","place":["Osmoy, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas C.","family":"Friggens","sequence":"additional","affiliation":[{"name":"PEGASE, INRAE, Institut Agro","place":["Saint-Gilles, France"]},{"name":"MoSAR, INRAE, AgroParisTech, Universit\u00e9 Paris-Saclay","place":["Gif-sur-Yvette, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-0337","authenticated-orcid":true,"given":"Gilles","family":"Foucras","sequence":"additional","affiliation":[{"name":"Univ Toulouse, ENVT, INRAE, IHAP","place":["Toulouse, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"pone.0356779.ref001","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1746-6148-10-114","article-title":"Gastrointestinal nematodes of dairy goats, anthelmintic resistance and practices of parasite control in Northern Italy","volume":"10","author":"SA Zanzani","year":"2014","journal-title":"BMC Vet Res"},{"issue":"2","key":"pone.0356779.ref002","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3168\/jds.2016-11313","article-title":"Linear and nonlinear genetic relationships between type traits and productive life in US dairy goats","volume":"100","author":"VJ Casta\u00f1eda-Bustos","year":"2017","journal-title":"J Dairy Sci"},{"issue":"7","key":"pone.0356779.ref003","doi-asserted-by":"crossref","first-page":"100544","DOI":"10.1016\/j.animal.2022.100544","article-title":"Targeting improved resilience in Merino sheep - correlations between immune competence and health and fitness traits","volume":"16","author":"BC Hine","year":"2022","journal-title":"Animal"},{"key":"pone.0356779.ref004","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.smallrumres.2019.05.011","article-title":"Genetic and genomic studies in ovine mastitis","volume":"176","author":"C Oget","year":"2019","journal-title":"Small Ruminant Res"},{"issue":"6","key":"pone.0356779.ref005","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.3168\/jds.2018-15664","article-title":"Divergent selection on milk somatic cell count in goats improves udder health and milk quality with no effect on nematode resistance","volume":"102","author":"R Rupp","year":"2019","journal-title":"J Dairy Sci"},{"issue":"10","key":"pone.0356779.ref006","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.3168\/jds.S0022-0302(99)75465-2","article-title":"Genetic parameters for clinical mastitis, somatic cell score, production, udder type traits, and milking ease in first lactation Holsteins","volume":"82","author":"R Rupp","year":"1999","journal-title":"J Dairy Sci"},{"issue":"6","key":"pone.0356779.ref007","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/asj.12066","article-title":"Estimation of genetic parameters for longevity traits in dairy cattle: a review with focus on the characteristics of analytical models","volume":"84","author":"O Sasaki","year":"2013","journal-title":"Anim Sci J"},{"issue":"12","key":"pone.0356779.ref008","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1017\/S175173111700088X","article-title":"Review: Deciphering animal robustness. 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