{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:22:21Z","timestamp":1787854941836,"version":"build-2784847793"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","award":["RS-2023-00243720"],"award-info":[{"award-number":["RS-2023-00243720"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean government","award":["RS-2026-25473234"],"award-info":[{"award-number":["RS-2026-25473234"]}]},{"DOI":"10.13039\/501100015825","name":"Korea University Anam Hospital","doi-asserted-by":"publisher","award":["K2330791"],"award-info":[{"award-number":["K2330791"]}],"id":[{"id":"10.13039\/501100015825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the efficacy of a 1-week postoperative regimen of topical bromfenac combined with corticosteroid versus corticosteroid monotherapy in preventing pseudophakic cystoid macular edema (PCME).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 226 eyes of 226 patients who underwent uneventful phacoemulsification. Patients were divided into Group A (n\u2009=\u2009158), receiving topical bromfenac 0.1% twice daily (BID) plus prednisolone acetate 1% (PDE) 6 times daily (6\/d) or every 2 hours while awake (q2hrs), and Group B (n\u2009=\u200968), receiving PDE alone 6\/d or q2hrs for the first postoperative week. Macular thickness was measured by Spectral-domain optical coherence tomography (SD-OCT) preoperatively and at postoperative week 5. PCME was defined as an increase in central subfield macular thickness (CSMT) with foveal cystoid changes. CSMT changes and PCME incidence were compared. A subgroup analysis evaluated the effect of PDE dosing frequency within the combination arm (6\/d vs. q2hrs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Postoperative absolute and relative CSMT changes were significantly smaller in Group A (13.3\u2009\u00b1\u200913.0 \u03bcm, 5.6\u2009\u00b1\u20095.3%) than in Group B (27.0\u2009\u00b1\u200933.7 \u03bcm, 11.2\u2009\u00b1\u200914.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The incidence of OCT-defined PCME was lower in Group A than in Group B (5.1% vs. 16.2%; OR = 0.28; 95% CI 0.11\u20130.72;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Among eyes developing PCME, the median CSMT increase was lower in Group A (38.5 \u03bcm) than in Group B (80.0 \u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). PCME incidence was numerically lower in [Bromfenac BID\u2009+\u2009PDE q2hrs] subgroup than [Bromfenac BID\u2009+\u2009PDE 6\/d] subgroup (2.0% vs. 10.0%, OR = 0.19; 95% CI 0.04\u20130.79;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.054).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A one-week course of topical bromfenac combined with topical corticosteroid therapy was associated with smaller postoperative increases in macular thickness and a lower incidence of OCT-defined PCME than corticosteroid monotherapy after cataract surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0356992","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:46:07Z","timestamp":1787852767000},"page":"e0356992","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of a one-week course of topical bromfenac combined with corticosteroid for prevention of pseudophakic cystoid macular edema (PCME)"],"prefix":"10.1371","volume":"21","author":[{"given":"Yoon Soo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Sun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-4409","authenticated-orcid":true,"given":"Young Sub","family":"Eom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Suk","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3985-990X","authenticated-orcid":true,"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"issue":"5","key":"pone.0356992.ref001","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0002-9394(53)90302-X","article-title":"A newly defined vitreous syndrome following cataract surgery: interpreted according to recent concepts of the structure of the vitreous, the seventh Francis I. 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