{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:14:31Z","timestamp":1788372871337,"version":"build-2803163510"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["23214MFDS256"],"award-info":[{"award-number":["23214MFDS256"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00443008"],"award-info":[{"award-number":["RS-2024-00443008"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2021M3H9A1030260"],"award-info":[{"award-number":["2021M3H9A1030260"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00411768"],"award-info":[{"award-number":["RS-2024-00411768"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2024-00443043"],"award-info":[{"award-number":["RS-2024-00443043"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014189","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","doi-asserted-by":"publisher","award":["RS-2026-25526966"],"award-info":[{"award-number":["RS-2026-25526966"]}],"id":[{"id":"10.13039\/501100014189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    The common marmoset (\n                    <jats:italic>Callithrix jacchus<\/jats:italic>\n                    ) is a widely used nonhuman primate model in biomedical research. However, access to infant tissues is limited, and descriptive histological information for early postnatal organ development is needed. We examined a qualitative, descriptive histological overview of five major organs (liver, kidney, spleen, lung and heart) in infant (0\u20133 weeks) and adult (&gt;12 months) marmosets using hematoxylin and eosin, Ki67 immunohistochemistry, Alcian blue\u2013periodic acid\u2013Schiff, and Sirius red staining. The examined infant livers showed multilayered hepatocyte cords, higher nuclear-to-cytoplasmic ratios, and extramedullary hematopoiesis, and the adult livers exhibited organized hepatic plates and mature stromal structures. The infant kidneys demonstrated active nephrogenesis with immature nephrons, showing progressively more mature glomerular morphology in adults. The spleen displayed small and poorly developed white pulp in infants but fewer, larger, and distinct white pulp structures in adults. The lungs showed thick interalveolarsepta and irregular airspaces during the early postnatal stages, with progressive septal thinning and expanded airspaces in maturity. The infant hearts exhibited loosely packed cardiomyocytes and developing valves, with the adult hearts showing hypertrophied, striated myocardium and compact collagenous valve structures. This study provides descriptive histological information for interpreting developmental features in infant marmosets and supports the use of these data in developmental primate pathology.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0357273","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:28:31Z","timestamp":1788370111000},"page":"e0357273","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histological characterization of major internal organs in infant common marmosets (Callithrix jacchus)"],"prefix":"10.1371","volume":"21","author":[{"given":"Hyeon Ah","family":"Kim","sequence":"first","affiliation":[{"name":"Seoul National University","place":["Seoul, Republic of Korea"],"department":["College of Veterinary Medicine, Department of Laboratory Animal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-5740","authenticated-orcid":true,"given":"Na-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital","place":["Seoul, Republic of Korea"],"department":["Department of Experiment Animal Research"]},{"name":"Seoul National University Hospital Marmoset Model Resource Bank (SNUH-MMRB)","place":["Seoul, Republic of Korea"]},{"name":"College of Veterinary Medicine, Seoul National University","place":["Seoul, Republic of Korea"],"department":["Department of Veterinary Pathology and Research Institute of Veterinary Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jina","family":"Kwak","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital","place":["Seoul, Republic of Korea"],"department":["Department of Experiment Animal Research"]},{"name":"Seoul National University Hospital Marmoset Model Resource Bank (SNUH-MMRB)","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital","place":["Seoul, Republic of Korea"],"department":["Department of Experiment Animal Research"]},{"name":"Graduate School of Translational Medicine, Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong Min","family":"Yoon","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["Seoul, Republic of Korea"],"department":["College of Veterinary Medicine, Department of Laboratory Animal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyeok","family":"Seok","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["Seoul, Republic of Korea"],"department":["College of Veterinary Medicine, Department of Laboratory Animal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["Seoul, Republic of Korea"],"department":["College of Veterinary Medicine, Department of Laboratory Animal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["Seoul, Republic of Korea"],"department":["College of Veterinary Medicine, Department of Laboratory Animal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Seoul National University","place":["Seoul, Republic of Korea"],"department":["Department of Veterinary Pathology and Research Institute of Veterinary Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2300-0978","authenticated-orcid":true,"given":"Jun Won","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University","place":["Seoul, Republic of Korea"],"department":["College of Veterinary Medicine, Department of Laboratory Animal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong-Cheol","family":"Kang","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital","place":["Seoul, Republic of Korea"],"department":["Department of Experiment Animal Research"]},{"name":"Seoul National University Hospital Marmoset Model Resource Bank (SNUH-MMRB)","place":["Seoul, Republic of Korea"]},{"name":"Graduate School of Translational Medicine, Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"5","key":"pone.0357273.ref001","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1177\/01926233221095449","article-title":"The common marmoset-biomedical research animal model applications and common spontaneous diseases","volume":"50","author":"H-J Han","year":"2022","journal-title":"Toxicol Pathol"},{"issue":"2","key":"pone.0357273.ref002","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1538\/expanim.22-0107","article-title":"The common marmoset in biomedical research: experimental disease models and veterinary management","volume":"72","author":"T Inoue","year":"2023","journal-title":"Exp Anim"},{"issue":"1","key":"pone.0357273.ref003","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.yrtph.2010.12.003","article-title":"Overview 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histology","author":"LM Ernst","year":"2019","edition":"2"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0357273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:28:39Z","timestamp":1788370119000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0357273"}},"subtitle":[],"editor":[{"given":"Serkan","family":"Erdo\u011fan","sequence":"first","affiliation":[{"name":"Namik Kemal University: Tekirdag Namik Kemal 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