{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:15:48Z","timestamp":1788372948148,"version":"build-2803163510"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We examined the association between social isolation (SI) and intrinsic capacity (IC) among older Hispanic adults in the United States and explored patterns of association across geographic and social subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using 2022 Health and Retirement Study data, we analyzed 615 Hispanic adults aged \u226560 years. IC (0\u201310) was derived from five domains, and SI (0\u20134) was measured using a composite index. Survey-weighted linear regression models were used to estimate the overall association between SI and IC. Exploratory interaction models and subgroup-specific analyses examined patterns across region of residence, community of residence, and nativity status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean IC was 6.48 (SD\u2009=\u20091.68), and mean SI was 0.98 (SD\u2009=\u20090.91). In the overall sample, SI was not significantly associated with IC (\u03b2\u2009= \u22120.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05). Exploratory subgroup analyses identified several patterns. Among rural participants, higher SI was associated with lower IC (\u03b2\u2009= \u22120.63,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), while among U.S.-born participants, higher SI was associated with lower IC (\u03b2\u2009= \u22120.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Across subgroups, higher household income and lower chronic disease burden were generally associated with higher IC(all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SI was not significantly associated with IC in the overall sample. Exploratory analyses identified potentially important patterns across residential and nativity groups, but these findings should be interpreted cautiously. Larger longitudinal studies are needed to clarify contextual differences and examine the pathways linking SI with functional aging among Hispanic older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0357275","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:36:17Z","timestamp":1788370577000},"page":"e0357275","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Social isolation and intrinsic capacity among older Hispanic adults in the United States: Exploring associations across geographic and social contexts"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-4229","authenticated-orcid":true,"given":"Cai","family":"Xu","sequence":"first","affiliation":[{"name":"Heritage College of Osteopathic Medicine, Ohio University","place":["Athens, Ohio, United States of America"],"department":["Department of Social Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehyun","family":"Shin","sequence":"additional","affiliation":[{"name":"Heritage College of Osteopathic Medicine, Ohio University","place":["Athens, Ohio, United States of America"],"department":["Department of Social Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Muniz-Terrera","sequence":"additional","affiliation":[{"name":"Heritage College of Osteopathic Medicine, Ohio University","place":["Athens, Ohio, United States of America"],"department":["Department of Social Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"pone.0357275.ref001","doi-asserted-by":"crossref","first-page":"104904","DOI":"10.1016\/j.archger.2022.104904","article-title":"Global prevalence of social isolation among community-dwelling older adults: a systematic review and meta-analysis","volume":"107","author":"RH Teo","year":"2023","journal-title":"Arch Gerontol Geriatr"},{"issue":"1","key":"pone.0357275.ref002","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/geronb\/gby037","article-title":"The epidemiology of social isolation: national health and aging trends study","volume":"75","author":"TKM Cudjoe","year":"2020","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"pone.0357275.ref003","doi-asserted-by":"crossref","first-page":"115937","DOI":"10.1016\/j.socscimed.2023.115937","article-title":"Social isolation and subsequent health and well-being in older adults: a longitudinal outcome-wide analysis","volume":"327","author":"A Nakagomi","year":"2023","journal-title":"Soc Sci Med"},{"key":"pone.0357275.ref004","author":"National Academies of Sciences E and M","year":"2020","journal-title":"Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System. 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