{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:14:22Z","timestamp":1788286462181,"version":"build-2803163510"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(No. 82270501, W2421094"],"award-info":[{"award-number":["(No. 82270501, W2421094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["No. 2021YFE0111300"],"award-info":[{"award-number":["No. 2021YFE0111300"]}]},{"name":"National Key Research and Development Program of China","award":["No. 2021YFF0702200 and No. 2021YFF0702204"],"award-info":[{"award-number":["No. 2021YFF0702200 and No. 2021YFF0702204"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sympathetic innervation is fundamentally required for physiological aortic homeostasis. Though it plays a vital important role in aortic function, its specific role in aortic dissection (AD) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this study, we explored the role of the sympathetic nervous system in AD by examining the effects of superior cervical ganglionectomy (SCGx) in mice. Using \u03b2-aminopropionitrile (BAPN) induced AD mice model at pre-lesional stage, the tyrosine hydroxylase (TH) expression, indicative of sympathetic activity, increased early in AD progression and correlated with aortic elastic lamina degradation. SCGx did not affect aortic structure within 2 weeks without BAPN treatment, but bilateral SCGx exacerbated AD severity, increasing rupture rates and tear range after BAPN and angiotensin II (AngII) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlighted the role of sympathetic nervous system in early AD stages and suggested bilateral SCGx may negatively impact AD progression. Furthermore, we found a trend toward smooth muscle cell phenotypic transformation after implementing SCGx in AD, revealing the integrity of the SCG played a pivotal role in preserving aortic homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0357281","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:29:27Z","timestamp":1788283767000},"page":"e0357281","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Superior cervical gangliectomy exacerbates the aortic dissection in mice"],"prefix":"10.1371","volume":"21","author":[{"given":"Zhonghui","family":"Zhu","sequence":"first","affiliation":[{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"School of Pharmacy, University of Chinese Academy of Sciences","place":["Beijing, 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Advances in Research on Neurodegeneration","author":"Y Glinka","year":"1997"},{"issue":"8","key":"pone.0357281.ref024","first-page":"533","article-title":"The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model","volume":"32","author":"D Hernandez-Baltazar","year":"2017","journal-title":"Neurologia"},{"issue":"14","key":"pone.0357281.ref025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0010-4035(73)90031-1","article-title":"Pharmacological nature of adrenergic innervation in rat aorta","volume":"4","author":"M Kuchii","year":"1973","journal-title":"Comp Gen Pharmacol"},{"issue":"3","key":"pone.0357281.ref026","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/ar.1091170305","article-title":"The effect of superior cervical ganglionectomy on the cell population of the rat adenohypophysis and on the estrous cycle","volume":"117","author":"JD IFFT","year":"1953","journal-title":"Anat 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