{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:53:47Z","timestamp":1792788827633,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hebei Province\u2019s Provincial Science and Technology Program - Special Project for Biomedical Industry Innovation","award":["262W7716D"],"award-info":[{"award-number":["262W7716D"]}]},{"name":"Hebei Natural Science Foundation Youth Science Fund Project","award":["H2026206187"],"award-info":[{"award-number":["H2026206187"]}]},{"name":"the General Program of the National Natural Science Foundation of China","award":["82271366"],"award-info":[{"award-number":["82271366"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Youth Project of the Beijing Natural Science Foundation","award":["7254341"],"award-info":[{"award-number":["7254341"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate choroid plexus\u2009. \u00a0\u00a0volume (CPV) alterations in patients with gliomas and glioneuronal and neuronal tumors (GNTs) and to evaluate their associations with tumor characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective observational cohort study, 811 patients with histologically confirmed brain tumors (674 gliomas and 137 GNTs) and 744 controls were included. All participants underwent 3.0 T MRI with 3D T1-weighted imaging, and patient scans were acquired preoperatively. The choroid plexus was automatically segmented on 3D T1-weighted images using a 3D nnU-Net\u2013based deep learning algorithm with expert quality control. CPV was normalized to total intracranial volume (CPV\/TIV). Lateral ventricular volume (LVV) was quantified using FreeSurfer and included as a covariate. Group comparisons were performed using Mann\u2013Whitney U and Kruskal\u2013Wallis tests after case-control matching. Multivariable linear regression analyses were conducted to assess independent associations while adjusting for age, sex, and LVV, with additional sensitivity analyses incorporating scanner type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with supratentorial tumors and controls, infratentorial tumors showed significantly larger CPV (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Tumor grade was not independently associated with CPV after adjustment among patients. Pediatric-type diffuse high-grade gliomas and GNTs exhibited larger CPV than adult-type diffuse gliomas (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). In exploratory molecular analyses of adult-type diffuse gliomas,\u2009+\u20097\/\u2009\u2212\u200910 status was associated with lower CPV (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009= \u22120.127,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CPV alterations in brain tumors are primarily associated with tumor location and histological classification rather than tumor grade. An exploratory association between +7\/\u2009\u2212\u200910 status and lower CPV was also observed, although this finding requires further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0357498","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:06:11Z","timestamp":1789495571000},"page":"e0357498","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Choroid plexus volume variation in patients with gliomas, glioneuronal and neuronal tumors: Associations with tumor characteristics"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4794-1157","authenticated-orcid":true,"given":"Jia","family":"Sun","sequence":"first","affiliation":[{"name":"Peking University Third Hospital","place":["Beijing, China"],"department":["Department of Radiology"]},{"name":"Beijing Tiantan Hospital, Capital Medical 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China"],"department":["Department of Clinical and Technical Support"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Research and Clinical Innovations, Neusoft Medical Systems Co., Ltd.","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital","place":["Tianjin, China"],"department":["Department of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhao","family":"Li","sequence":"additional","affiliation":[{"name":"Rongcheng County People\u2019s Hospital","place":["Xiongan New Area, Hebei, China"],"department":["Department of Internal Medicine II"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Duan","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"],"department":["Department of Radiology"]},{"name":"Second Hospital of Hebei Medical University","place":["Shijiazhuang, Hebei, China"],"department":["Department of 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