{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:15:19Z","timestamp":1788372919356,"version":"build-2803163510"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Comparing outcomes of PreserFlo\n                      <jats:sup>TM<\/jats:sup>\n                      MicroShunt in eyes with primary open-angle (POAG) and pseudoexfoliative glaucoma (PEXG) through a matched analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective matched-pair analysis of patients undergoing PreserFlo\n                      <jats:sup>TM<\/jats:sup>\n                      MicroShunt (PFMS) due to POAG (n\u2009=\u200925) and PEXG (n\u2009=\u200925). Success rates (A\/B: IOP\u2009\u2264\u200921 \/ 18 mmHg\u2009+\u2009IOP reduction \u226520% from baseline; C: IOP\u2009\u2264\u200915 mmHg\u2009+\u2009IOP reduction \u226525%; D: IOP\u2009\u2264\u200912 mmHg\u2009+\u2009IOP reduction \u226530%) and secondary outcomes were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty eyes of 49 patients were included. At 12 months, complete and qualified success rates for Criteria A \u2013 D were 68.0% and 96.0%, 68.0% and 96.0%, 64.0% and 72.0%, and 32.0% and 32.0%, respectively, in the POAG group, compared with 44.0% and 76.0%, 40.0% and 72.0%, 32.0% and 52.0%, and 8.0% and 12.0%, respectively, in the PEXG group (p\u2009=\u20090.039, 0.024, 0.189, and 0.271, respectively). Mean preoperative IOP decreased from 25.12 mmHg (POAG) and 25.64 mmHg (PEXG, p\u2009=\u20090.98) to 12.64 mmHg and 15.04 mmHg postoperatively (p\u2009=\u20090.043). The mean number of IOP-lowering drops was significantly lower in eyes with POAG (0.52\u2009\u00b1\u20091.01) than with PEXG (1.3\u2009\u00b1\u20091.55; p\u2009=\u20090.031) after 12 months. Eyes with PEXG had significantly higher rates of postoperative complications than eyes with POAG (p\u2009=\u20090.038) with no vision-threatening sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PFMS is a safe and effective procedure for reducing IOP in eyes with POAG and PEXG, with lower IOP levels being achieved in eyes with POAG. Significantly more postoperative complications and interventions were needed in eyes with PEXG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0357501","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:34:03Z","timestamp":1788370443000},"page":"e0357501","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative outcomes of PreserFloTMMicroShunt in primary open-angle and pseudoexfoliative glaucoma: A matched analysis"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8498-7396","authenticated-orcid":true,"given":"Leonie","family":"Bourauel","sequence":"first","affiliation":[{"name":"University of Bonn","place":["Bonn, Germany"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0143-0873","authenticated-orcid":true,"given":"Benjamin","family":"Aretz","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn","place":["Bonn, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Petrak","sequence":"additional","affiliation":[{"name":"University of Bonn","place":["Bonn, Germany"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[{"name":"University of Bonn","place":["Bonn, Germany"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Mercieca","sequence":"additional","affiliation":[{"name":"University of Bonn","place":["Bonn, Germany"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Liegl","sequence":"additional","affiliation":[{"name":"University of Bonn","place":["Bonn, Germany"],"department":["Department of Ophthalmology"]},{"name":"Klinikum Dortmund, University Witten\/Herdecke","place":["Dortmund, Germany"],"department":["Department of Ophthalmology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"3","key":"pone.0357501.ref001","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"HA Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"issue":"12","key":"pone.0357501.ref002","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis","volume":"5","author":"SR Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"issue":"2","key":"pone.0357501.ref003","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ophtha.2007.04.050","article-title":"Glaucoma and quality of life: the Salisbury eye evaluation","volume":"115","author":"EE Freeman","year":"2008","journal-title":"Ophthalmology"},{"issue":"11","key":"pone.0357501.ref004","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Y-C Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"pone.0357501.ref005","unstructured":"Glaucoma: diagnosis and management NICE guideline. 2017."},{"issue":"12","key":"pone.0357501.ref006","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.ophtha.2021.05.023","article-title":"Ab-externo microshunt versus trabeculectomy in primary open-angle glaucoma: one-year results from a 2-year randomized, multicenter study","volume":"128","author":"ND Baker","year":"2021","journal-title":"Ophthalmology"},{"key":"pone.0357501.ref007","unstructured":"Ontario Health. 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