{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:38:14Z","timestamp":1792607894138,"version":"4.5.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    This project addresses the challenge of controlling\n                    <jats:italic>Dermanyssus gallinae<\/jats:italic>\n                    infestations in poultry farms. A cohort-based model is developed that couples the pharmacokinetics of Fluralaner (Exzolt \u00ae) in the plasma of laying hens with the dynamics of the mites, enabling the simulation of various treatment administration strategies while balancing costs. The study reveals that administering a reduced dose of Fluralaner (Exzolt \u00ae) at high frequencies, in conjunction with a customized infestation tolerance threshold for each farm, provides a cost-effective solution for mite control. Specifically, this approach offers significant savings, with up to a 14,15% reduction in treatment costs in a case study involving moderate infestation levels. The findings emphasize that, in many cases, maintaining mite populations below acceptable limits is more economical than complete eradication. This research contributes to advancing poultry farm management practices and optimizing profitability.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0357723","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:44:58Z","timestamp":1792604698000},"page":"e0357723","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A cohort-based population model for the Poultry Red Mite Dermanyssus gallinae (Acari: Dermanyssidae): Application to explore potential pathways for control strategies using Fluralaner as a case study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1772-9132","authenticated-orcid":true,"given":"Maroua","family":"Bettaieb","sequence":"first","affiliation":[{"name":"Institution de la Recherche et de l\u2019Enseignement Sup\u00e9rieur Agricoles, Universit\u00e9 de la Manouba","place":["Sidi Thabet, Tunisia"],"department":["\u00c9cole Nationale de M\u00e9decine V\u00e9t\u00e9rinaire"]},{"name":"Institut Pasteur de Tunis, Universit\u00e9 Tunis El-Manar","place":["Tunis, Tunisia"],"department":["Laboratoire de bio-(informatique, math\u00e9matiques et statistique)"]},{"name":"Universit\u00e9 de Carthage & Institution de la Recherche et de l\u2019Enseignement Sup\u00e9rieur Agricoles","place":["Tunis, Tunisia"],"department":["Laboratoire de recherche Ressources G\u00e9n\u00e9tiques Animales et Alimentaires (RGAA), D\u00e9partement des Productions Animales, Institut National Agronomiques de Tunisie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Louhichi","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Tunis, Universit\u00e9 Tunis El-Manar","place":["Tunis, Tunisia"],"department":["Laboratoire de bio-(informatique, math\u00e9matiques et statistique)"]},{"name":"Universit\u00e9 Tunis El-Manar","place":["Tunis, Tunisia"],"department":["\u00c9cole Nationale d\u2019Ing\u00e9nieurs de Tunis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Aziz","family":"Darghouth","sequence":"additional","affiliation":[{"name":"Institution de la Recherche et de l\u2019Enseignement Sup\u00e9rieur Agricoles, Universit\u00e9 de la Manouba","place":["Sidi Thabet, Tunisia"],"department":["\u00c9cole Nationale de M\u00e9decine V\u00e9t\u00e9rinaire"]},{"name":"Laboratoire de Recherche Epidemiologie des infections enzootiques des herbivores en Tunisie: application \u00e0 la lutte (LR02AGR03)","place":["Sidi Thabet, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slimane","family":"Ben Miled","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Tunis, Universit\u00e9 Tunis El-Manar","place":["Tunis, Tunisia"],"department":["Laboratoire de bio-(informatique, math\u00e9matiques et 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