{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:31Z","timestamp":1790791111470,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background and objective<\/jats:title>\n Despite expanded access to antiretroviral therapy (ART), people living with HIV (PLWH) continue to experience high hospitalization rates, particularly in low- and middle-income countries. This study aimed to describe the causes of hospitalization in a cohort of PLWH treated at a high-complexity referral center in Bogot\u00e1, Colombia, and to assess variations across the pre-pandemic, pandemic, and post-pandemic periods of COVID-19.<\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n We conducted a retrospective cohort study including hospitalization episodes among adults with confirmed HIV infection between 2018 and 2024. Clinical characteristics, causes of hospitalization, and outcomes were compared across the epidemiological periods related to the COVID-19 pandemic.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 872 hospitalization episodes corresponding to 584 patients were analyzed. The median age was 34 years, and 89.1% were men. Although 68.7% of patients had a history of ART use, 54.8% were admitted with detectable viral load. Non\u2013AIDS-defining causes predominated across all periods (61.8%), with a progressive increase from the pre-pandemic to the post-pandemic period (55.3%, 63.1%, and 70.1%, respectively). A sustained increase in hospitalizations due to mental health disorders was observed over time (4.3%, 4.6%, and 7.8%). Among AIDS-defining conditions, tuberculosis (15.8%) and\n Pneumocystis jirovecii<\/jats:italic>\n pneumonia (14.9%) were the most frequent. Hospitalizations due to opportunistic infections were associated with longer length of stay (median 14 vs. 6 days; p\u2009<\u20090.001) and higher 30-day mortality (8.6% vs. 2.6%; p\u2009<\u20090.001) compared with non\u2013AIDS-defining hospitalizations, with a proportional increase in events attributable to tuberculosis and Kaposi sarcoma.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n An epidemiological transition towards non-AIDS-defining causes of hospitalization is evident, comparable to patterns observed in high-income countries; however, a substantial burden of tuberculosis, Kaposi sarcoma, and late HIV diagnosis persists, likely reflecting ongoing structural gaps in HIV care. Following the COVID-19 pandemic, an increase in hospitalizations related to mental health disorders was observed. Taken together, these findings highlight the urgent need to strengthen early diagnosis, active case finding, and tuberculosis prevention, as well as to enhance the implementation of comprehensive care models that improve retention in care for PLWH in low- and middle-income countries.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0357788","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:32:06Z","timestamp":1790789526000},"page":"e0357788","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Causes of hospitalization among people living with HIV in a tertiary-care hospital in Bogot\u00e1, Colombia, 2018\u20132024"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-0182","authenticated-orcid":true,"given":"Daniela Luc\u00eda","family":"Rico-Bol\u00edvar","sequence":"first","affiliation":[{"name":"Pontificia Universidad Javeriana","place":["Bogot\u00e1, Colombia"],"department":["Faculty of Medicine, Department of Internal Medicine"]},{"name":"Hospital Universitario San Ignacio","place":["Bogot\u00e1, Colombia"],"department":["Division of Infectious Diseases, Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ndida","family":"D\u00edaz-Brochero","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana","place":["Bogot\u00e1, Colombia"],"department":["Faculty of Medicine, Department of Internal Medicine"]},{"name":"Hospital Universitario San Ignacio","place":["Bogot\u00e1, Colombia"],"department":["Division of Infectious Diseases, Department of Internal Medicine"]},{"name":"Pontificia Universidad Javeriana","place":["Bogot\u00e1, Colombia"],"department":["Department of Clinical Epidemiology and Biostatistics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hattemer","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine","place":["Cincinnati, Ohio, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6210-2424","authenticated-orcid":true,"given":"Camila Andrea","family":"Bejarano-Mora","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Ignacio","place":["Bogot\u00e1, Colombia"],"department":["Division of Infectious Diseases, Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bejarano-Mora","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Ignacio","place":["Bogot\u00e1, Colombia"],"department":["Division of Infectious Diseases, Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-5809","authenticated-orcid":true,"given":"Moises A.","family":"Huaman","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine","place":["Cincinnati, Ohio, United States of America"],"department":["Division of Infectious Diseases, Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1833-1599","authenticated-orcid":true,"given":"Sandra Liliana","family":"Valderrama-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana","place":["Bogot\u00e1, Colombia"],"department":["Faculty of Medicine, Department of Internal Medicine"]},{"name":"Hospital Universitario San Ignacio","place":["Bogot\u00e1, Colombia"],"department":["Division of Infectious Diseases, Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"pone.0357788.ref001","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2249.2008.03645.x","article-title":"Special anniversary review: Twenty-five years of human immunodeficiency virus research: Successes and challenges","volume":"152","author":"RA Weiss","year":"2008","journal-title":"Clinical and Experimental Immunology"},{"key":"pone.0357788.ref002","volume-title":"HIV and AIDS","author":"World Health Organization","year":"2025"},{"key":"pone.0357788.ref003","volume-title":"Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022\u20132030","author":"World Health Organization","year":"2022"},{"key":"pone.0357788.ref004","volume-title":"AIDS, crisis and the power to transform: UNAIDS Global AIDS Update 2025","author":"Joint United Nations Programme on HIV\/AIDS U","year":"2025"},{"key":"pone.0357788.ref005","unstructured":"Smith CJ, Ryom L, Weber R, Morlat P, Pradier C, Reiss P, et al. 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