{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:04:46Z","timestamp":1789495486667,"version":"build-2803163510"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["code: 71233"],"award-info":[{"award-number":["code: 71233"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies suggests that illness uncertainty is associated with quality of life in chronic illness, yet the underlying mechanisms remain unclear, particularly in coronary artery disease (CAD). This study aims to explore the relationship between uncertainty in illness, perceived stress, coping strategies, and quality of life in patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study was conducted in 150 patients with CAD recruited at a specialized heart clinic affiliated with Tabriz University of Medical Sciences, Tabriz (Iran) in 2024. Uncertainty in illness, perceived stress, coping strategies, and QoL were evaluated through self-reported questionnaires. The multiple mediation model was analyzed using SPSS and Amos software, with a P-value of less than 0.05 considered significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean (SD) scores of uncertainty in illness, perceived stress, coping strategies, physical, and psychological quality of life were 66.77 (11.97) (in a range of 23\u2013115), 29.57 (4.96), 59.91 (10.32), 11.95 (2.90), and 16.48 (1.69), respectively. The Pearson correlation indicated a significant positive correlation between uncertainty in illness and perceived stress (r\u2009=\u20090.50, P\u2009&lt;\u20090.001). Additionally, uncertainty in illness was negatively and significantly correlated with coping strategies (r\u2009=\u2009\u22120.41, P\u2009&lt;\u20090.001) and physical QoL (r\u2009=\u2009\u22120.32, P\u2009&lt;\u20090.001). There was also a significant negative correlation between perceived stress and coping strategies (r\u2009=\u2009\u22120.29, P\u2009&lt;\u20090.001) as well as between perceived stress and physical QoL (r\u2009=\u2009\u22120.37, P\u2009&lt;\u20090.001). Furthermore, a significant positive correlation was found between psychological QoL and physical QoL (r\u2009=\u20090.39, P\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Uncertainty in illness and perceived stress are important factors that affect QoL in patients with coronary artery disease. It is recommended to implement well-structured interventions aimed at decreasing illness uncertainty and perceived stress while improving physical quality of life in patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0357910","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:33:07Z","timestamp":1789493587000},"page":"e0357910","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The pathway analysis of relationship between illness uncertainty, perceived stress, coping strategies, and quality of life in patients with coronary artery disease"],"prefix":"10.1371","volume":"21","author":[{"given":"Atefeh","family":"Allahbakhshian","sequence":"first","affiliation":[{"name":"Tabriz University of Medical Sciences","place":["Tabriz, Iran"],"department":["Department of Medical Surgical 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A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"4","key":"pone.0357910.ref036","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1207\/s15327906mbr2604_2","article-title":"The Maslach Burnout Inventory: Validating Factorial Structure and Invariance Across Intermediate, Secondary, and University Educators","volume":"26","author":"BM Byrne","year":"1991","journal-title":"Multivariate Behav Res"},{"issue":"9","key":"pone.0357910.ref037","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1007\/s12144-021-01998-9","article-title":"Healthy and clinical meta-data and aggregated mini-mental status exam scores for the Persian speaking population","volume":"42","author":"A Ramezani","year":"2021","journal-title":"Curr Psychol"},{"issue":"3","key":"pone.0357910.ref038","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity","volume":"34","author":"J Ware","year":"1996","journal-title":"Med Care"},{"issue":"4","key":"pone.0357910.ref039","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"S Cohen","year":"1983","journal-title":"J Health Soc Behav"},{"issue":"11","key":"pone.0357910.ref040","first-page":"111","article-title":"The survey of relationship between perceived stress coping strategies and suicide ideation among students at University of Guilan, Iran","volume":"1","author":"F Asghari","year":"2013","journal-title":"International Journal of Education and Research"},{"key":"pone.0357910.ref041","volume-title":"Coping inventory for stressful situations","author":"NS Endler","year":"1990"},{"issue":"1","key":"pone.0357910.ref042","first-page":"1","article-title":"Validation of Endler & Parker coping scale of stressful situations","volume":"4","author":"F Ghoreyshi Rad","year":"2010","journal-title":"International Journal of Behavioral Sciences"},{"issue":"6","key":"pone.0357910.ref043","first-page":"125","article-title":"The Relationship between Stress and Coronary Artery Disease in Yazd in 2012","volume":"14","author":"B Azari far","year":"2016","journal-title":"Tolooebehdasht"},{"key":"pone.0357910.ref044","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12955-016-0481-z","article-title":"Effects of social support, hope and resilience on quality of life among Chinese bladder cancer patients: a cross-sectional study","volume":"14","author":"M-Y Li","year":"2016","journal-title":"Health Qual Life 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for Heart Transplantation"},{"issue":"2","key":"pone.0357910.ref051","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00012272-200012000-00008","article-title":"Caregiving and care receiving among a technologically dependent heart failure population","volume":"23","author":"LD Scott","year":"2000","journal-title":"ANS Adv Nurs Sci"},{"issue":"3","key":"pone.0357910.ref052","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1871529X22666220830093651","article-title":"Quality of Life and Depression Assessment in Patients with Acute Coronary Syndrome: A Cross-Sectional Study","volume":"22","author":"TP Varghese","year":"2022","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"issue":"12","key":"pone.0357910.ref053","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/pon.3960","article-title":"Cancer caregiver quality of life: need for targeted intervention","volume":"25","author":"MI 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