{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:04:01Z","timestamp":1789581841196,"version":"build-2803163510"},"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR077578"],"award-info":[{"award-number":["R01AR077578"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM136393"],"award-info":[{"award-number":["R35GM136393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    The transcriptional control of skeletal muscle differentiation requires the coordinated activity of lineage-defining transcription factors, signal-responsive regulators, chromatin modifiers, and ATP-dependent chromatin remodeling enzymes. Here, we identify TCEAL7, a member of the X-linked, poorly characterized TCEAL family of proteins, as a direct downstream target of BRG1-containing mammalian SWI\/SNF (mSWI\/SNF) complexes and calcineurin signaling during myoblast differentiation. Analyses of previously published datasets showed that pharmacological inhibition of mSWI\/SNF bromodomains or knockdown of the BRG1 ATPase, but not knockdown of the homologue BRM ATPase, significantly reduced\n                    <jats:italic>Tceal7<\/jats:italic>\n                    expression in differentiating C2C12 myoblasts. We demonstrate that BRG1 occupancy at the\n                    <jats:italic>Tceal7<\/jats:italic>\n                    promoter increased during differentiation, paralleling the induction of\n                    <jats:italic>Tceal7<\/jats:italic>\n                    expression and nuclear accumulation of TCEAL7 protein. BRG1 functions in part by integrating calcium-dependent cues via the phosphatase calcineurin (Cn); we also determined that Cn knockdown or pharmacological inhibition of Cn suppressed\n                    <jats:italic>Tceal7<\/jats:italic>\n                    expression and impaired myoblast differentiation. The data suggest that both BRG1-driven chromatin remodeling and Cn signaling converge on\n                    <jats:italic>Tceal7<\/jats:italic>\n                    regulation. Functionally,\n                    <jats:italic>Tceal7<\/jats:italic>\n                    knockdown altered cell proliferation and disrupted myoblast differentiation, at least in part due to reduced expression of\n                    <jats:italic>Myogenin<\/jats:italic>\n                    , which encodes a transcription factor that is an essential differentiation determinant. RNA-seq analysis revealed broad dysregulation of myogenic, metabolic, and cell-cycle gene programs in\n                    <jats:italic>Tceal7<\/jats:italic>\n                    -deficient cells, including changes in cyclin-dependent kinase-regulated pathways consistent with prior reports linking TCEAL7 to cell-cycle control. Together, these findings identify TCEAL7 as a necessary component of the myogenic regulatory network whose expression is controlled by BRG1-dependent chromatin remodeling and Cn activity.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0358038","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:38:00Z","timestamp":1789580280000},"page":"e0358038","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tceal7 is a BRG1-regulated target of calcineurin signaling that promotes myoblast differentiation"],"prefix":"10.1371","volume":"21","author":[{"given":"Sandhya","family":"Yadav","sequence":"first","affiliation":[{"name":"University of Massachusetts Chan Medical School","place":["Worcester, Massachusetts, United States of America"],"department":["Department of Biochemistry and Molecular Biotechnology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School","place":["Worcester, Massachusetts, United States of America"],"department":["Department of Biochemistry and Molecular Biotechnology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monserrat","family":"Olea-Flores","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School","place":["Worcester, Massachusetts, United States of America"],"department":["Department of Biochemistry and Molecular Biotechnology"]},{"name":"Wesleyan University","place":["Middletown, Connecticut, United States of America"],"department":["Department of Molecular Biology and Biochemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-0822","authenticated-orcid":true,"given":"Teresita","family":"Padilla-Benavides","sequence":"additional","affiliation":[{"name":"Wesleyan University","place":["Middletown, Connecticut, United States of America"],"department":["Department of Molecular Biology and Biochemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N.","family":"Imbalzano","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School","place":["Worcester, Massachusetts, United States of America"],"department":["Department of Biochemistry and Molecular Biotechnology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"1","key":"pone.0358038.ref001","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13059-020-02172-3","article-title":"Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions","volume":"21","author":"E Navas-P\u00e9rez","year":"2020","journal-title":"Genome Biol"},{"key":"pone.0358038.ref002","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2148-5-54","article-title":"Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events","volume":"5","author":"EE Winter","year":"2005","journal-title":"BMC Evol Biol"},{"issue":"2","key":"pone.0358038.ref003","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0378-1119(94)90112-0","article-title":"A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII","volume":"143","author":"CH Yeh","year":"1994","journal-title":"Gene"},{"issue":"4","key":"pone.0358038.ref004","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/oxfordjournals.jbchem.a130150","article-title":"DNA dependent RNA polymerase from Ehrlich ascites tumor cells. II. Factors stimulating the activity of RNA polymerase II","volume":"73","author":"S Natori","year":"1973","journal-title":"J Biochem"},{"issue":"9","key":"pone.0358038.ref005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0968-0004(96)10045-1","article-title":"The RNA polymerase II general elongation factors","volume":"21","author":"D Reines","year":"1996","journal-title":"Trends Biochem Sci"},{"issue":"23","key":"pone.0358038.ref006","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1021\/bi00668a018","article-title":"Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II","volume":"15","author":"K Sekimizu","year":"1976","journal-title":"Biochemistry"},{"issue":"4","key":"pone.0358038.ref007","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1521-1878(200004)22:4<327::AID-BIES3>3.0.CO;2-4","article-title":"Transcription elongation factor SII","volume":"22","author":"M Wind","year":"2000","journal-title":"Bioessays"},{"issue":"7873","key":"pone.0358038.ref008","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"J Jumper","year":"2021","journal-title":"Nature"},{"issue":"1","key":"pone.0358038.ref009","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41392-023-01381-z","article-title":"AlphaFold2 and its applications in the fields of biology and medicine","volume":"8","author":"Z Yang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"pone.0358038.ref010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1615\/CritRevEukaryotGeneExpr.2025061337","article-title":"Transcription elongation factor A (SII)-like (TCEAL) family members: re-evaluation of predicted structure and summary of expression and functions","volume":"35","author":"S Yadav","year":"2025","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"1","key":"pone.0358038.ref011","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41467-018-03148-5","article-title":"A family of unconventional deubiquitinases with modular chain specificity determinants","volume":"9","author":"T Hermanns","year":"2018","journal-title":"Nat Commun"},{"key":"pone.0358038.ref012","article-title":"S18-phosphorylation of USP7 regulates interaction with TCEAL4 that defines specific complexes and potentially distinct functions","author":"FSD Querques","year":"2021","journal-title":"bioRxiv"},{"key":"pone.0358038.ref013","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"D Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"6489","key":"pone.0358038.ref014","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/370481a0","article-title":"Facilitated binding of TATA-binding protein to nucleosomal DNA","volume":"370","author":"AN Imbalzano","year":"1994","journal-title":"Nature"},{"issue":"6489","key":"pone.0358038.ref015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/370477a0","article-title":"Nucleosome disruption and enhancement of activator binding by a human SW1\/SNF complex","volume":"370","author":"H Kwon","year":"1994","journal-title":"Nature"},{"issue":"19","key":"pone.0358038.ref016","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1002\/j.1460-2075.1996.tb00921.x","article-title":"Purification and biochemical heterogeneity of the mammalian SWI-SNF complex","volume":"15","author":"W Wang","year":"1996","journal-title":"EMBO J"},{"issue":"3","key":"pone.0358038.ref017","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/cr.2011.32","article-title":"ATP-dependent chromatin remodeling: genetics, genomics and mechanisms","volume":"21","author":"DC Hargreaves","year":"2011","journal-title":"Cell Res"},{"issue":"1","key":"pone.0358038.ref018","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/abbs\/gmr099","article-title":"Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer","volume":"44","author":"JI Wu","year":"2012","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"5","key":"pone.0358038.ref019","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.09.032","article-title":"Modular organization and assembly of SWI\/SNF family chromatin remodeling complexes","volume":"175","author":"N Mashtalir","year":"2018","journal-title":"Cell"},{"issue":"9","key":"pone.0358038.ref020","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.201624.115","article-title":"SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells","volume":"26","author":"AR Barutcu","year":"2016","journal-title":"Genome Res"},{"key":"pone.0358038.ref021","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.dnarep.2015.04.023","article-title":"The SWI\/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis","volume":"32","author":"PM Brownlee","year":"2015","journal-title":"DNA Repair (Amst)"},{"key":"pone.0358038.ref022","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.dnarep.2019.03.007","article-title":"SWI\/SNF: Complex complexes in genome stability and cancer","volume":"77","author":"C Ribeiro-Silva","year":"2019","journal-title":"DNA Repair (Amst)"},{"issue":"1","key":"pone.0358038.ref023","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1756-8935-6-42","article-title":"Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains","volume":"6","author":"S-I Takebayashi","year":"2013","journal-title":"Epigenetics Chromatin"},{"issue":"5","key":"pone.0358038.ref024","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500447","article-title":"Mammalian SWI\/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics","volume":"1","author":"C Kadoch","year":"2015","journal-title":"Sci Adv"},{"issue":"1","key":"pone.0358038.ref025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055119","article-title":"The spectrum of SWI\/SNF mutations, ubiquitous in human cancers","volume":"8","author":"AH Shain","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"pone.0358038.ref026","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ng.2628","article-title":"Proteomic and bioinformatic analysis of mammalian SWI\/SNF complexes identifies extensive roles in human malignancy","volume":"45","author":"C Kadoch","year":"2013","journal-title":"Nat Genet"},{"issue":"2","key":"pone.0358038.ref027","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/84826","article-title":"Mammalian SWI\/SNF complexes promote MyoD-mediated muscle differentiation","volume":"27","author":"IL de la Serna","year":"2001","journal-title":"Nat Genet"},{"issue":"10","key":"pone.0358038.ref028","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1128\/MCB.25.10.3997-4009.2005","article-title":"MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex","volume":"25","author":"IL de la Serna","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"4","key":"pone.0358038.ref029","article-title":"Baf60c in skeletal muscle regulates adipose tissue thermogenesis via Musclin-mediated endocrine signaling","volume":"4","author":"S Han","year":"2025","journal-title":"Life Metab"},{"issue":"7","key":"pone.0358038.ref030","article-title":"Baf155 regulates skeletal muscle metabolism via HIF-1a signaling","volume":"21","author":"J-S Kang","year":"2023","journal-title":"PLoS Biol"},{"issue":"5","key":"pone.0358038.ref031","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nm.3144","article-title":"Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation","volume":"19","author":"Z-X Meng","year":"2013","journal-title":"Nat Med"},{"issue":"14","key":"pone.0358038.ref032","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1093\/nar\/gkab617","article-title":"The Bromodomains of the mammalian SWI\/SNF (mSWI\/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation","volume":"49","author":"T Sharma","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"pone.0358038.ref033","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.1074\/jbc.M608898200","article-title":"Myogenin and the SWI\/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis","volume":"282","author":"Y Ohkawa","year":"2007","journal-title":"J Biol Chem"},{"issue":"6451","key":"pone.0358038.ref034","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/366170a0","article-title":"BRG1 contains a conserved domain of the SWI2\/SNF2 family necessary for normal mitotic growth and transcription","volume":"366","author":"PA Khavari","year":"1993","journal-title":"Nature"},{"issue":"23","key":"pone.0358038.ref035","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1093\/emboj\/17.23.6979","article-title":"Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha)","volume":"17","author":"JC Reyes","year":"1998","journal-title":"EMBO J"},{"issue":"5","key":"pone.0358038.ref036","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1097-2765(00)80384-6","article-title":"A C\/EBP beta isoform recruits the SWI\/SNF complex to activate myeloid genes","volume":"4","author":"E Kowenz-Leutz","year":"1999","journal-title":"Mol Cell"},{"issue":"23","key":"pone.0358038.ref037","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1101\/gad.209901","article-title":"Cooperation between C\/EBPalpha TBP\/TFIIB and SWI\/SNF recruiting domains is required for adipocyte differentiation","volume":"15","author":"TA Pedersen","year":"2001","journal-title":"Genes Dev"},{"issue":"17","key":"pone.0358038.ref038","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1093\/emboj\/20.17.4935","article-title":"The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation","volume":"20","author":"N Barker","year":"2001","journal-title":"EMBO J"},{"issue":"6","key":"pone.0358038.ref039","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1073\/pnas.1013751108","article-title":"The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels","volume":"108","author":"CT Griffin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"pone.0358038.ref040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006757","article-title":"Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition","volume":"13","author":"G Wagner","year":"2017","journal-title":"PLoS Genet"},{"issue":"23","key":"pone.0358038.ref041","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1101\/gad.9.23.2911","article-title":"Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite","volume":"9","author":"AE M\u00fcnsterberg","year":"1995","journal-title":"Genes Dev"},{"issue":"11","key":"pone.0358038.ref042","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1242\/dev.121.11.3675","article-title":"Myogenesis in paraxial mesoderm: preferential induction by dorsal neural tube and by cells expressing Wnt-1","volume":"121","author":"HM Stern","year":"1995","journal-title":"Development"},{"issue":"10","key":"pone.0358038.ref043","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500723","article-title":"Selective targeting of the BRG\/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance","volume":"1","author":"O Fedorov","year":"2015","journal-title":"Sci Adv"},{"issue":"10","key":"pone.0358038.ref044","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1021\/acs.jmedchem.6b00012","article-title":"Identification of a chemical probe for Family VIII bromodomains through optimization of a fragment hit","volume":"59","author":"BS Gerstenberger","year":"2016","journal-title":"J Med Chem"},{"key":"pone.0358038.ref045","doi-asserted-by":"crossref","first-page":"1160227","DOI":"10.3389\/fcell.2023.1160227","article-title":"Regulation of the Wnt signaling pathway during myogenesis by the mammalian SWI\/SNF ATPase BRG1","volume":"11","author":"T Sharma","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"pone.0358038.ref046","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.3390\/ijms23042036","article-title":"Tceal5 and Tceal7 function in C2C12 myogenic differentiation via exosomes in fetal bovine serum","volume":"23","author":"A Sawada","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"2","key":"pone.0358038.ref047","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/BJ20091906","article-title":"Myogenic regulatory factors transactivate the Tceal7 gene and modulate muscle differentiation","volume":"428","author":"X Shi","year":"2010","journal-title":"Biochem J"},{"issue":"7","key":"pone.0358038.ref048","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.3390\/ijms24076264","article-title":"Tceal7 regulates skeletal muscle development through its interaction with Cdk1","volume":"24","author":"Z Xiong","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"3","key":"pone.0358038.ref049","first-page":"446","article-title":"Transcription regulation of Tceal7 by the triple complex of Mef2c, Creb1 and Myod","volume":"11","author":"Z Xiong","year":"2022","journal-title":"Biology (Basel)"},{"issue":"5","key":"pone.0358038.ref050","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4103\/1008-682X.122861","article-title":"Expression of androgen receptor target genes in skeletal muscle","volume":"16","author":"K Rana","year":"2014","journal-title":"Asian J Androl"},{"issue":"2","key":"pone.0358038.ref051","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/jcsm.12265","article-title":"Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle","volume":"9","author":"JJ Hulmi","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"pone.0358038.ref052","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3803\/EnM.2020.35.2.456","article-title":"Transformation of mature osteoblasts into bone lining cells and RNA sequencing-based transcriptome profiling of mouse bone during mechanical unloading","volume":"35","author":"AR Hong","year":"2020","journal-title":"Endocrinol Metab (Seoul)"},{"key":"pone.0358038.ref053","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.semcdb.2017.11.011","article-title":"Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis","volume":"72","author":"PS Zammit","year":"2017","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"pone.0358038.ref054","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(94)90572-X","article-title":"Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals","volume":"78","author":"K Polyak","year":"1994","journal-title":"Cell"},{"issue":"9","key":"pone.0358038.ref055","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s12032-025-02973-1","article-title":"From cell cycle control to cancer therapy: exploring the role of CDK1 and CDK2 in tumorigenesis","volume":"42","author":"J Gupta","year":"2025","journal-title":"Med Oncol"},{"issue":"4","key":"pone.0358038.ref056","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/0092-8674(83)90300-8","article-title":"Cytoplasmic activation of human nuclear genes in stable heterocaryons","volume":"32","author":"HM Blau","year":"1983","journal-title":"Cell"},{"issue":"19","key":"pone.0358038.ref057","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00063-19","article-title":"Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI\/SNF chromatin remodeling enzyme","volume":"39","author":"H Witwicka","year":"2019","journal-title":"Mol Cell Biol"},{"issue":"7","key":"pone.0358038.ref058","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"4","key":"pone.0358038.ref059","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"7","key":"pone.0358038.ref060","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Y Liao","year":"2014","journal-title":"Bioinformatics"},{"issue":"12","key":"pone.0358038.ref061","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"issue":"3","key":"pone.0358038.ref062","first-page":"100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"T Wu","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"9","key":"pone.0358038.ref063","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1101\/gr.771603","article-title":"Assessment of genome-wide protein function classification for Drosophila melanogaster","volume":"13","author":"H Mi","year":"2003","journal-title":"Genome Res"},{"issue":"1","key":"pone.0358038.ref064","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/nar\/gkg115","article-title":"PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification","volume":"31","author":"PD Thomas","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"pone.0358038.ref065","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1159\/000354462","article-title":"MicroRNA-182 promotes tumor cell growth by targeting transcription elongation factor A-like 7 in endometrial carcinoma","volume":"32","author":"Y Guo","year":"2013","journal-title":"Cell Physiol Biochem"},{"issue":"11","key":"pone.0358038.ref066","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.ymthe.2019.07.011","article-title":"Hypoxic glioma cell-secreted exosomal miR-301a activates Wnt\/beta-catenin signaling and promotes radiation resistance by targeting TCEAL7","volume":"27","author":"X Yue","year":"2019","journal-title":"Molecular Therapy"},{"issue":"1","key":"pone.0358038.ref067","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054671","article-title":"Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis","volume":"8","author":"C Huang","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"pone.0358038.ref068","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/ng1378","article-title":"p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci","volume":"36","author":"C Simone","year":"2004","journal-title":"Nat Genet"},{"key":"pone.0358038.ref069","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1038\/ncomms8441","article-title":"Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme","volume":"6","author":"BT Nasipak","year":"2015","journal-title":"Nat Commun"},{"issue":"12","key":"pone.0358038.ref070","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1073\/pnas.76.12.6270","article-title":"Calcineurin: a calcium- and calmodulin-binding protein of the nervous system","volume":"76","author":"CB Klee","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"pone.0358038.ref071","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes","volume":"66","author":"J Liu","year":"1991","journal-title":"Cell"},{"key":"pone.0358038.ref072","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1101\/gad.7.12a.2456","article-title":"Dimerization specificity of myogenic helix-loop-helix DNA-binding factors directed by nonconserved hydrophilic residues","volume":"7","author":"M Shirakata","year":"1993","journal-title":"Genes Dev"},{"issue":"1","key":"pone.0358038.ref073","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/dbio.1995.0002","article-title":"Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors","volume":"172","author":"EN Olson","year":"1995","journal-title":"Dev Biol"},{"key":"pone.0358038.ref074","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2018.10.003","article-title":"Transcriptional and chromatin regulation in interferon and innate antiviral gene expression","volume":"44","author":"N Au-Yeung","year":"2018","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"pone.0358038.ref075","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/cells10020358","article-title":"The metabolic stability of the nicotinic acetylcholine receptor at the neuromuscular junction","volume":"10","author":"I Martinez-Pena Y Valenzuela","year":"2021","journal-title":"Cells"},{"key":"pone.0358038.ref076","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-031-88361-3_9","article-title":"Skeletal muscle damage and inflammation","volume":"1478","author":"TA Washington","year":"2025","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"pone.0358038.ref077","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s12015-022-10334-y","article-title":"Muscle stem cell function is impaired in \u03b22-adrenoceptor knockout mice","volume":"18","author":"TE Koike","year":"2022","journal-title":"Stem Cell Rev Rep"},{"key":"pone.0358038.ref078","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/1471-2164-10-448","article-title":"Expression profiling of skeletal muscle following acute and chronic beta2-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm","volume":"10","author":"MA Pearen","year":"2009","journal-title":"BMC Genomics"},{"issue":"3","key":"pone.0358038.ref079","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1440-1681.2009.05312.x","article-title":"Novel role for \u00df-adrenergic signalling in skeletal muscle growth, development and regeneration","volume":"37","author":"JG Ryall","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"pone.0358038.ref080","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbrc.2023.09.048","article-title":"Postnatal skeletal muscle myogenesis governed by signal transduction networks: MAPKs and PI3K-Akt control multiple steps","volume":"682","author":"T Endo","year":"2023","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0358038.ref081","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/bs.pmbts.2017.11.026","article-title":"Wnt signaling in skeletal muscle development and regeneration","volume":"153","author":"F Girardi","year":"2018","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"12","key":"pone.0358038.ref082","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1042\/CS20240341","article-title":"Endothelin-1 impairs skeletal muscle myogenesis and development via ETB receptors and p38 MAPK signaling pathway","volume":"138","author":"S-Y Liu","year":"2024","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"pone.0358038.ref083","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/jcsm.12974","article-title":"A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis","volume":"13","author":"M Bensalah","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"pone.0358038.ref084","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/10739680600618843","article-title":"Alpha-adrenergic control of skeletal muscle circulation at rest and during exercise in aging humans","volume":"13","author":"FA Dinenno","year":"2006","journal-title":"Microcirculation"},{"key":"pone.0358038.ref085","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1113\/jphysiol.2008.164566","article-title":"Alpha-adrenergic signalling activates protein kinase D and causes nuclear efflux of the transcriptional repressor HDAC5 in cultured adult mouse soleus skeletal muscle fibres","volume":"587","author":"Y Liu","year":"2009","journal-title":"J Physiol"},{"issue":"24","key":"pone.0358038.ref086","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1406728111","article-title":"The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels","volume":"111","author":"FA Iannotti","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0358038.ref087","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1242\/jcs.049742","article-title":"Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner","volume":"122","author":"Y Ono","year":"2009","journal-title":"J Cell Sci"},{"issue":"13","key":"pone.0358038.ref088","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1002\/j.1460-2075.1996.tb00705.x","article-title":"The hbrm and BRG-1 proteins, components of the human SNF\/SWI complex, are phosphorylated and 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