{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:05:51Z","timestamp":1789495551261,"version":"build-2803163510"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Society of Schema Therapy","award":["Grant Award 2024; No. 2024\/ISST\/1"],"award-info":[{"award-number":["Grant Award 2024; No. 2024\/ISST\/1"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Within Panksepp\u2019s neuroaffective theory, emotional\u2013motivational systems constitute the biological basis for individual differences in the experience and regulation of emotions, which may be related to loneliness. At the same time, these systems may be associated with the formation of early maladaptive schemas which \u2013 according to Young\u2019s concept \u2013 affect interpersonal functioning. The aim of this study was to examine the relationships between emotional\u2013motivational systems and the sense of loneliness, and to determine whether early maladaptive schemas statistically mediate these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The study involved 323 participants aged 18 to 66 years (mean age: M = 26.9). The following instruments were used: the Revised UCLA Loneliness Scale (R-UCLA), the Brief Form of the Affective Neuroscience Personality Scales (BANPS), and the Young Schema Questionnaire \u2013 Short Form (YSQ-S3-PL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All maladaptive schemas, schema domains, and systems \u2013 except for the SEEKING system \u2013 were significantly associated with the sense of loneliness. The strongest associations were observed for the SADNESS \/ PANIC \/ SEPARATION DISTRESS and FEAR systems. Emotional\u2013motivational systems were also associated with early maladaptive schemas, with the strongest relationships found for four systems: SADNESS \/ PANIC \/ SEPARATION DISTRESS, FEAR, RAGE, and PLAY. Schema domains showed significant statistical mediation in the relationships between primal emotional systems and loneliness, except for the SEEKING system, where no mediation effect was found. The primary mediator in the tested relationships was the Disconnection\/Rejection domain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings suggest that early maladaptive schemas related to unmet needs for belonging, love, and relational safety are associated with the relationships between primal emotional systems and loneliness. In particular, the Disconnection\/Rejection schema domain emerged as the most prominent statistical mediator in the analyzed models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0358449","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:41:13Z","timestamp":1789494073000},"page":"e0358449","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationships between primal emotional systems and the sense of loneliness: The mediating role of early maladaptive schemas"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3451-1250","authenticated-orcid":true,"given":"Monika","family":"Talarowska-Dublicka","sequence":"first","affiliation":[{"name":"University of Lodz","place":["Poland"],"department":["Institute of Psychology, Faculty of Educational 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Beutel","year":"2017","journal-title":"BMC Psychiatry"},{"issue":"2","key":"pone.0358449.ref002","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/1745691615570616","article-title":"Loneliness: clinical import and interventions","volume":"10","author":"S Cacioppo","year":"2015","journal-title":"Perspect Psychol Sci"},{"issue":"1","key":"pone.0358449.ref003","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/jopy.12938","article-title":"Alone but flowing: the effects of autotelic personality and extraversion on solitary flow","volume":"93","author":"DCK Tse","year":"2025","journal-title":"J Pers"},{"issue":"1","key":"pone.0358449.ref004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/jopy.12939","article-title":"Investigating solitude as a tool for downregulation of daily arousal using ecological momentary assessments","volume":"93","author":"T-VT Nguyen","year":"2025","journal-title":"J 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Haucke","year":"2022","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"pone.0358449.ref016","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1089\/ars.2017.7488","article-title":"Environmental stressors and their impact on health and disease with focus on oxidative stress","volume":"28","author":"T M\u00fcnzel","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"pone.0358449.ref017","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neubiorev.2020.01.006","article-title":"The neuroscience of sadness: a multidisciplinary synthesis and collaborative review","volume":"111","author":"JA Arias","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0358449.ref018","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuroimage.2016.11.063","article-title":"Functional connectivity in the resting brain as biological correlate of the affective neuroscience personality scales","volume":"147","author":"N Deris","year":"2017","journal-title":"Neuroimage"},{"key":"pone.0358449.ref019","volume-title":"The archaeology of mind: neuroevolutionary origins of human emotion","author":"J Panksepp","year":"2012"},{"issue":"7","key":"pone.0358449.ref020","article-title":"A new approach of personality and psychiatric disorders: a short version of the Affective Neuroscience Personality Scales","volume":"7","author":"J-B Pingault","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"pone.0358449.ref021","doi-asserted-by":"crossref","first-page":"926","DOI":"10.5209\/rev_SJOP.2011.v14.n2.38","article-title":"Spanish validation of the affective neuroscience personality scales","volume":"14","author":"V Abella","year":"2011","journal-title":"Span J Psychol"},{"issue":"9","key":"pone.0358449.ref022","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.neubiorev.2011.08.003","article-title":"The basic emotional circuits of mammalian brains: do animals have affective lives?","volume":"35","author":"J Panksepp","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0358449.ref023","first-page":"797","article-title":"Sadness and grief.","volume-title":"Handbook of Emotions","author":"G Bonanno","year":"2008"},{"key":"pone.0358449.ref024","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3389\/fnins.2018.01025","article-title":"Selected principles of pankseppian affective neuroscience","volume":"12","author":"KL Davis","year":"2019","journal-title":"Front Neurosci"},{"key":"pone.0358449.ref025","doi-asserted-by":"crossref","first-page":"846315","DOI":"10.3389\/fnbeh.2022.846315","article-title":"Neurobiology of loneliness, isolation, and loss: integrating human and animal perspectives","volume":"16","author":"EM Vitale","year":"2022","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"pone.0358449.ref026","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/15294145.2012.10773683","article-title":"An evolutionary 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Ancestral primary-process separation-distress (PANIC\/GRIEF) and diminished brain reward (SEEKING) processes in the genesis of depressive affect","volume":"74","author":"J Panksepp","year":"2011","journal-title":"Psychiatry"},{"issue":"9","key":"pone.0358449.ref028","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.neubiorev.2011.01.003","article-title":"Affective neuroscientific and neuropsychoanalytic approaches to two intractable psychiatric problems: why depression feels so bad and what addicts really want","volume":"35","author":"MR Zellner","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0358449.ref029","first-page":"6","article-title":"A synopsis of affective neuroscience \u2013 naturalizing the mammalian mind","volume":"19","author":"J Panksepp","year":"2012","journal-title":"J Conscious Stud"},{"issue":"3","key":"pone.0358449.ref030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000538752","article-title":"Oxytocin-augmented modular-based group intervention for loneliness: a proof-of-concept randomized controlled trial","volume":"93","author":"R Berger","year":"2024","journal-title":"Psychother Psychosom"},{"key":"pone.0358449.ref031","doi-asserted-by":"crossref","DOI":"10.1017\/pen.2024.4","article-title":"Jaak Panksepp\u2019s primary emotions are associated with Diener\u2019s global life satisfaction: How low arousal of the sadness\/separation distress system could form the core of life satisfaction?","volume":"7","author":"KL Davis","year":"2024","journal-title":"Personal Neurosci"},{"key":"pone.0358449.ref032","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fpsyg.2017.00464","article-title":"Primary emotional systems and personality: an evolutionary perspective","volume":"8","author":"C Montag","year":"2017","journal-title":"Front Psychol"},{"issue":"1","key":"pone.0358449.ref033","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0278-2626(03)00003-4","article-title":"At the interface of the affective, behavioral, and cognitive neurosciences: decoding the emotional feelings of the brain","volume":"52","author":"J Panksepp","year":"2003","journal-title":"Brain Cogn"},{"key":"pone.0358449.ref034","volume-title":"Contextual schema therapy: an integrative approach to personality disorders, emotional dysregulation, and interpersonal functioning","author":"E Roediger","year":"2018"},{"key":"pone.0358449.ref035","volume-title":"Schema therapy: a practitioner\u2019s guide","author":"J Young","year":"2003"},{"issue":"3","key":"pone.0358449.ref036","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5114\/nan.2017.71667","article-title":"Young\u2019s theory of early maladaptive schemes from the perspective of the neurodevelopmental theory of depression","volume":"12","author":"M Talarowska","year":"2017","journal-title":"nin"},{"issue":"4","key":"pone.0358449.ref037","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/1754073911410740","article-title":"What is meant by calling emotions basic","volume":"3","author":"P Ekman","year":"2011","journal-title":"Emot Rev"},{"issue":"13","key":"pone.0358449.ref038","doi-asserted-by":"crossref","first-page":"8062","DOI":"10.3390\/ijerph19138062","article-title":"Affective neuroscience personality scales and early maladaptive schemas in depressive disorders","volume":"19","author":"M Talarowska","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"pone.0358449.ref039","first-page":"213","article-title":"Affective neuroscience correlates of personality and the formation of early maladaptive schemas - preliminary reports","volume":"33","author":"ME Talarowska","year":"2024","journal-title":"Postep Psychiatr Neurol"},{"issue":"2","key":"pone.0358449.ref040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.5114\/cipp.2017.69681","article-title":"Analysis of the psychometric properties of the revised UCLA loneliness scale in a polish adolescent sample","volume":"6","author":"MM Kwiatkowska","year":"2017","journal-title":"Current Issues in Personality Psychology"},{"issue":"3","key":"pone.0358449.ref041","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1037\/0022-3514.39.3.472","article-title":"The revised UCLA loneliness scale: concurrent and discriminant validity evidence","volume":"39","author":"D Russell","year":"1980","journal-title":"J Pers Soc Psychol"},{"issue":"3","key":"pone.0358449.ref042","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1037\/a0032576","article-title":"A brief form of the affective neuroscience personality scales","volume":"25","author":"FS Barrett","year":"2013","journal-title":"Psychol Assess"},{"key":"pone.0358449.ref043","volume-title":"Adaptacja kwestionariuszy osobowo\u015bci","author":"R\u0141 Drwal","year":"1995"},{"issue":"1","key":"pone.0358449.ref044","doi-asserted-by":"crossref","DOI":"10.1080\/09581596.2025.2574959","article-title":"Brief form of affective neuroscience personality scales (BANPS) \u2013 polish adaptation","volume":"35","author":"M Jura\u015b-Darowny","year":"2025","journal-title":"Critical Public Health"},{"key":"pone.0358449.ref045","volume-title":"Young schema questionnaire \u2013 short form 3 (YSQ-S3)","author":"J Young","year":"2005"},{"issue":"4","key":"pone.0358449.ref046","first-page":"707","article-title":"Polska adaptacja i walidacja kr\u00f3tkiej wersji kwestionariusza schemat\u00f3w Younga (YSQ-S3-PL)","volume":"52","author":"J Oettingen","year":"2018","journal-title":"Psychiatria Polska"},{"issue":"3","key":"pone.0358449.ref047","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3758\/BRM.40.3.879","article-title":"Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models","volume":"40","author":"KJ Preacher","year":"2008","journal-title":"Behav Res Methods"},{"issue":"6","key":"pone.0358449.ref048","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"RM Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"key":"pone.0358449.ref049","volume-title":"Introduction to mediation, moderation, and conditional process analysis: a regression-based approach","author":"AF Hayes","year":"2022"},{"issue":"7","key":"pone.0358449.ref050","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.3758\/s13428-022-01988-0","article-title":"Questions of value, questions of magnitude: an exploration and application of methods for comparing indirect effects in multiple mediator models","volume":"55","author":"JJ Coutts","year":"2023","journal-title":"Behav Res Methods"},{"key":"pone.0358449.ref051","first-page":"6357873","article-title":"Epigenetic mechanisms in the neurodevelopmental theory of depression","volume":"2020","author":"M Talarowska","year":"2020","journal-title":"Depress Res Treat"},{"issue":"8","key":"pone.0358449.ref052","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2174\/1381612822666151230110738","article-title":"Cognition and emotions in recurrent depressive disorders - 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