{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:07:54Z","timestamp":1789754874237,"version":"4.0.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008332","name":"Universitat Ramon Llull","doi-asserted-by":"publisher","award":["2021-URL-Proj-004"],"award-info":[{"award-number":["2021-URL-Proj-004"]}],"id":[{"id":"10.13039\/501100008332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008332","name":"Universitat Ramon Llull","doi-asserted-by":"publisher","award":["APR-FPCEE2122\/04"],"award-info":[{"award-number":["APR-FPCEE2122\/04"]}],"id":[{"id":"10.13039\/501100008332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Exercise is a promising non-pharmacological intervention for motor and non-motor symptoms in Parkinson\u2019s disease (PD). However, direct comparisons between basic physical training (BPT) and dual-task training remain limited. The objective of the current clinical trial is to evaluate clinical and functional effects of BPT and a BPT combined with dual-task functional exercises (BPT\u2009+\u2009FE) in individuals with PD. In this randomized controlled trial, 24 participants with idiopathic PD were allocated to BPT, BPT\u2009+\u2009FE, or a no-intervention control group (Con). Interventions lasted 12 weeks (three 60-minute sessions\/week). Outcomes included quality of life (PDQ-39), depressive symptoms (BDI), lower-limb strength (1-minute Sit-to-Stand Test, STS), and functional mobility (Timed Up and Go, TUG). Group effects were analyzed using permutation-based ANOVA with Bonferroni correction. Both interventions significantly improved physical performance vs. controls. STS gains were observed for BPT vs. Con (Mean Difference, MD\u2009=\u200931.00; p\u2009=\u2009.0026) and BPT\u2009+\u2009FE vs. Con (MD\u2009=\u200919.00; p\u2009=\u2009.0026). TUG times improved for BPT vs. Con (MD\u2009=\u2009\u20132.07s; p\u2009=\u2009.0039) and BPT\u2009+\u2009FE vs. Con (MD\u2009=\u2009\u20132.43s; p\u2009=\u2009.0028). Although BDI and PDQ-39 did not show statistically significant changes between group differences (r_rb\u2009=\u2009\u20130.429 and \u20130.339, respectively), several subscales demonstrated medium effect sizes suggesting potentially meaningful trends: emotional well-being (BPT: r_rb\u2009=\u2009\u20130.428; BPT\u2009+\u2009FE: r_rb\u2009=\u2009\u20130.446), bodily discomfort (BPT: r_rb\u2009=\u2009\u20130.524), and activities of daily living (BPT\u2009+\u2009FE: r_rb\u2009=\u2009\u20130.429). In conclusion, both programs improved physical performance in PD. Patient-reported outcomes did not reach statistical significance, but effect-size patterns suggest possible psychosocial benefits that warrant confirmation in larger trials.<\/jats:p>\n                  <jats:p>Trial registration<\/jats:p>\n                  <jats:p>\n                    ClinicalTrials.gov,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05963425\" xlink:type=\"simple\">NCT05963425<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0358534","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:31:35Z","timestamp":1789752695000},"page":"e0358534","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of basic and dual-task training programs on physical function in Parkinson\u2019s disease: The PARKEX study"],"prefix":"10.1371","volume":"21","author":[{"given":"Juan Carlos","family":"Maga\u00f1a","sequence":"first","affiliation":[{"name":"Universitat Ramon Llull, Facultat de Psicologia, Ci\u00e8ncies de l\u2019Educaci\u00f3 i de l\u2019Esport Blanquerna","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Enr\u00edquez-Calzada","sequence":"additional","affiliation":[{"name":"Grup de Malalties Neurodegeneratives de la Vall d\u2019Hebron. Vall d\u2019Hebron Institut de Recerca (VHIR)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-688X","authenticated-orcid":true,"given":"Roger","family":"Prat","sequence":"additional","affiliation":[{"name":"Universitat Ramon Llull, Facultat de Psicologia, Ci\u00e8ncies de l\u2019Educaci\u00f3 i de l\u2019Esport Blanquerna","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia M.","family":"Deus","sequence":"additional","affiliation":[{"name":"MIA-Portugal, Multidisciplinary Institute of Ageing, University of Coimbra","place":["Coimbra, Portugal"]},{"name":"CIBB, Center for Innovative Biomedicine and Biotechnology, University of Coimbra","place":["Coimbra, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana P.","family":"Pereira","sequence":"additional","affiliation":[{"name":"UCIBIO, Applied Molecular Biosciences Unit","place":["Caparica, Portugal"],"department":["Department of Chemistry, Faculty of Science and Technology"]},{"name":"Associate Laboratory i4HB-Institute for Health and Bioeconomy","place":["Caparica, Portugal"],"department":["Faculty of Science and Technology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Avellanet","sequence":"additional","affiliation":[{"name":"Hospital Nostra Senyora de Meritxell","place":["Escaldes-Engordany, Andorra"]},{"name":"Universitat d\u2019Andorra","place":["Sant Juli\u00e0 de L\u00f2ria, Andorra"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Gea","sequence":"additional","affiliation":[{"name":"Hospital Nostra Senyora de Meritxell","place":["Escaldes-Engordany, Andorra"]},{"name":"Universitat d\u2019Andorra","place":["Sant Juli\u00e0 de L\u00f2ria, Andorra"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Laguna","sequence":"additional","affiliation":[{"name":"Grup de Malalties Neurodegeneratives de la Vall d\u2019Hebron. Vall d\u2019Hebron Institut de Recerca (VHIR)","place":["Barcelona, Spain"]},{"name":"Aligning Science Across Parkinson\u2019s (ASAP) Collaborative Research Network","place":["Chevy Chase, Maryland, United States of America"]},{"name":"Institut de Neuroci\u00e8ncies-Autonomous Universitat de Barcelona (INc-UAB)","place":["Cerdanyola del Vall\u00e8s, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Martinez-Vicente","sequence":"additional","affiliation":[{"name":"Grup de Malalties Neurodegeneratives de la Vall d\u2019Hebron. Vall d\u2019Hebron Institut de Recerca (VHIR)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ona","family":"Perez-Larumbe","sequence":"additional","affiliation":[{"name":"Universitat Ramon Llull, Facultat de Ci\u00e8ncies de la Salut Blanquerna","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gin\u00e9-Garriga","sequence":"additional","affiliation":[{"name":"Universitat Ramon Llull, Facultat de Psicologia, Ci\u00e8ncies de l\u2019Educaci\u00f3 i de l\u2019Esport Blanquerna","place":["Barcelona, Spain"]},{"name":"Universitat Ramon Llull, Facultat de Ci\u00e8ncies de la Salut Blanquerna","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Hern\u00e1ndez-Vara","sequence":"additional","affiliation":[{"name":"Grup de Malalties Neurodegeneratives de la Vall d\u2019Hebron. Vall d\u2019Hebron Institut de Recerca (VHIR)","place":["Barcelona, Spain"]},{"name":"Departament de Neurologia. 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One"},{"key":"pone.0358534.ref017","volume-title":"Borg\u2019s Perceived Exertion and Pain Scales","author":"G Borg","year":"1998"},{"issue":"10","key":"pone.0358534.ref018","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jsams.2017.03.004","article-title":"Skeletal muscle functional and structural adaptations after eccentric overload flywheel resistance training: a systematic review and meta-analysis","volume":"20","author":"S Maroto-Izquierdo","year":"2017","journal-title":"J Sci Med Sport"},{"key":"pone.0358534.ref019","volume-title":"The flywheel workout zones: how to pick the right inertia","author":"F Correa","year":"2016"},{"key":"pone.0358534.ref020","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mds.29410","article-title":"Levodopa Dose Equivalency in Parkinson\u2019s Disease: Updated Systematic Review and Proposals","volume":"38","author":"ST Jost","year":"2023","journal-title":"Movement Disorders"},{"issue":"15","key":"pone.0358534.ref021","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results","volume":"23","author":"CG Goetz","year":"2008","journal-title":"Mov Disord"},{"issue":"4","key":"pone.0358534.ref022","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"ZS Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"pone.0358534.ref023","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/mds.27862","article-title":"The Movement Disorder Society Nonmotor Rating Scale: Initial Validation Study","volume":"35","author":"KR Chaudhuri","year":"2020","journal-title":"Movement Disorders"},{"issue":"6","key":"pone.0358534.ref024","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/jnnp.73.6.629","article-title":"The Parkinson\u2019s disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson\u2019s disease","volume":"73","author":"KR Chaudhuri","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"pone.0358534.ref025","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/ageing\/26.5.353","article-title":"The Parkinson\u2019s Disease Questionnaire (PDQ-39): development and validation of a Parkinson\u2019s disease summary index score","volume":"26","author":"C Jenkinson","year":"1997","journal-title":"Age Ageing"},{"issue":"7","key":"pone.0358534.ref026","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/mds.10438","article-title":"Health status measurement in Parkinson\u2019s disease: validity of the PDQ-39 and Nottingham Health Profile","volume":"18","author":"P Hagell","year":"2003","journal-title":"Mov Disord"},{"issue":"6","key":"pone.0358534.ref027","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/1531-8257(200011)15:6<1221::AID-MDS1024>3.0.CO;2-H","article-title":"The validity of the Beck Depression Inventory as a screening and diagnostic instrument for depression in patients with Parkinson\u2019s disease","volume":"15","author":"AF Leentjens","year":"2000","journal-title":"Mov Disord"},{"key":"pone.0358534.ref028","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0149-7189(83)90019-8","article-title":"Assessing client satisfaction among Hispanics","volume":"6","author":"RE Roberts","year":"1983","journal-title":"Eval Program Plann"},{"key":"pone.0358534.ref029","volume-title":"ACSM\u2019s Guidelines for Exercise Testing and Prescription","author":"C Ozemek","year":"2025","edition":"12"},{"issue":"4","key":"pone.0358534.ref030","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1109\/TNSRE.2012.2236577","article-title":"Quantification of motor impairment in Parkinson\u2019s disease using an instrumented timed up and go test","volume":"21","author":"L Palmerini","year":"2013","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"issue":"2","key":"pone.0358534.ref031","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/ptj\/81.2.810","article-title":"Reliability of measurements obtained with the Timed \u201cUp & Go\u201d test in people with Parkinson disease","volume":"81","author":"S Morris","year":"2001","journal-title":"Phys Ther"},{"key":"pone.0358534.ref032","unstructured":"Posit team. Integrated Development Environment for R. 2023. http:\/\/www.posit.com\/"},{"key":"pone.0358534.ref033","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: Foundation for Statistical Computing. 2023."},{"issue":"1","key":"pone.0358534.ref034","doi-asserted-by":"crossref","first-page":"4","DOI":"10.17712\/nsj.2023.1.20220105","article-title":"The role of exercise in Parkinson\u2019s Disease","volume":"28","author":"MA Almikhlafi","year":"2023","journal-title":"Neurosciences (Riyadh)"},{"issue":"10423","key":"pone.0358534.ref035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson\u2019s disease","volume":"403","author":"Y Ben-Shlomo","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"pone.0358534.ref036","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1186\/s13063-022-06703-0","article-title":"Study in Parkinson\u2019s disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial","volume":"23","author":"CG Patterson","year":"2022","journal-title":"Trials"},{"issue":"2","key":"pone.0358534.ref037","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1001\/jamaneurol.2017.3517","article-title":"Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial","volume":"75","author":"M Schenkman","year":"2018","journal-title":"JAMA Neurol"},{"issue":"11","key":"pone.0358534.ref038","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S1474-4422(19)30285-6","article-title":"Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson\u2019s disease: a double-blind, randomised controlled trial","volume":"18","author":"NM van der Kolk","year":"2019","journal-title":"Lancet Neurol"},{"issue":"7","key":"pone.0358534.ref039","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S1474-4422(13)70123-6","article-title":"Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson\u2019s disease","volume":"12","author":"GM Petzinger","year":"2013","journal-title":"Lancet Neurol"},{"issue":"4","key":"pone.0358534.ref040","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s00415-023-12151-w","article-title":"Dual-task gait training improves cognition and resting-state functional connectivity in Parkinson\u2019s disease with postural instability and gait disorders","volume":"271","author":"M Leocadi","year":"2024","journal-title":"J Neurol"},{"issue":"23","key":"pone.0358534.ref041","doi-asserted-by":"crossref","first-page":"8124","DOI":"10.3390\/s21238124","article-title":"The Maximum Flywheel Load: A Novel Index to Monitor Loading Intensity of Flywheel Devices","volume":"21","author":"A Mu\u00f1oz-L\u00f3pez","year":"2021","journal-title":"Sensors (Basel)"},{"issue":"11","key":"pone.0358534.ref042","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1152\/japplphysiol.00008.2013","article-title":"Eccentric exercise in rehabilitation: safety, feasibility, and application","volume":"116","author":"P LaStayo","year":"2014","journal-title":"J Appl Physiol (1985)"},{"key":"pone.0358534.ref043","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2016.00483","article-title":"Moderate Load Eccentric Exercise; A Distinct Novel Training Modality","volume":"7","author":"H Hoppeler","year":"2016","journal-title":"Frontiers in Physiology"},{"key":"pone.0358534.ref044","first-page":"1941980","article-title":"Fatigue and Muscle Strength Involving Walking Speed in Parkinson\u2019s Disease: Insights for Developing Rehabilitation Strategy for PD","volume":"2017","author":"Y-Z Huang","year":"2017","journal-title":"Neural Plast"},{"issue":"9","key":"pone.0358534.ref045","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.apmr.2006.05.016","article-title":"The safety and feasibility of high-force eccentric resistance exercise in persons with Parkinson\u2019s disease","volume":"87","author":"LE Dibble","year":"2006","journal-title":"Arch Phys Med Rehabil"},{"key":"pone.0358534.ref046","article-title":"Mobilizing Parkinson\u2019s Disease: The Future of Exercise","volume":"8","author":"T Ellis","year":"2018","journal-title":"J Parkinsons Dis"},{"issue":"11","key":"pone.0358534.ref047","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrneurol.2017.128","article-title":"Long-term effects of exercise and physical therapy in people with Parkinson disease","volume":"13","author":"MK Mak","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"pone.0358534.ref048","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/mdc3.13823","article-title":"Efficacy of Dual-Task Training in Patients with Parkinson\u2019s Disease: A Systematic Review with Meta-Analysis","volume":"10","author":"H Garc\u00eda-L\u00f3pez","year":"2023","journal-title":"Mov Disord Clin Pract"},{"issue":"1","key":"pone.0358534.ref049","article-title":"Physical exercise for people with Parkinson\u2019s disease: a systematic review and network meta-analysis","volume":"1","author":"M Ernst","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"pone.0358534.ref050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.apmr.2022.07.021","article-title":"Exercise for Depressive Symptoms in Parkinson Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials","volume":"104","author":"D Feller","year":"2023","journal-title":"Arch Phys Med Rehabil"},{"issue":"11","key":"pone.0358534.ref051","doi-asserted-by":"crossref","first-page":"6849","DOI":"10.3390\/ijerph19116849","article-title":"Effect of Physical Activity on Depression in Patients with Parkinson\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"19","author":"J Tian","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"7","key":"pone.0358534.ref052","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1474-4422(20)30064-8","article-title":"Integrated and patient-centred management of Parkinson\u2019s disease: a network model for reshaping chronic neurological care","volume":"19","author":"BR Bloem","year":"2020","journal-title":"Lancet Neurol"},{"issue":"9","key":"pone.0358534.ref053","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.3390\/biomedicines10092228","article-title":"Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration","volume":"10","author":"LR Doblado","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"pone.0358534.ref054","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/jnnp-2022-330967","article-title":"Effect of long-term Tai Chi training on Parkinson\u2019s disease: a 3.5-year follow-up cohort study","volume":"95","author":"G Li","year":"2024","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0358534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:31:46Z","timestamp":1789752706000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0358534"}},"subtitle":[],"editor":[{"given":"Meiling","family":"Qi","sequence":"first","affiliation":[{"name":"Shandong University","place":["CHINA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0358534","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}