{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:08Z","timestamp":1790704868379,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Outstanding Youth Fund of The Natural Science Foundation of Guangxi in China","award":["2023GXNSFFA026007"],"award-info":[{"award-number":["2023GXNSFFA026007"]}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023GXNSFAA026287"],"award-info":[{"award-number":["2023GXNSFAA026287"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015360","name":"State Key Laboratory of Infectious Disease Prevention and Control","doi-asserted-by":"publisher","award":["GXJKKJ2025YB00"],"award-info":[{"award-number":["GXJKKJ2025YB00"]}],"id":[{"id":"10.13039\/501100015360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to explore the association between HIV testing trajectories, sexual behavior characteristics and HIV exposure prevention prophylaxis use, to provide a basis for developing more precise HIV prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>This analysis utilized pseudonymized data from a three-arm, open-label randomized controlled trial (RCT) conducted in Guangxi, China, between 2021 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled 327 participants from southern China. Longitudinal data\u2014including HIV testing, sexual risk behaviors, and prophylaxis use (PrEP\/PEP)\u2014were collected at baseline and quarterly for one year. Group-based trajectory modeling (GBTM) was used to identify behavioral patterns, and person-years (PY) of follow-up were calculated to estimate incidence densities of PrEP\/PEP use and STI occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 76.45% of men who have sex with men (MSM) received HIV testing less frequently than once every three months, and HIV self-testing (HIVST) was not significantly associated with increased rates of HIV testing (HT). In the HT model, MSM who underwent middle-frequency HT were less likely to report having fewer temporary sexual partners (OR 0.120, 95% CI 0.017\u20130.85, P\u2009=\u20090.034) and regular sexual partners (OR 0.502, 95% CI 0.267\u20130.943, P\u2009=\u20090.032). The use of PrEP increased with higher HT frequency, demonstrating a 3.39-fold (95% CI: 1.377\u20138.843, P\u2009=\u20090.008) increase in the middle frequency group and a 7.335-fold (95% CI: 2.505\u201321.475, P\u2009&lt;\u20090.001) increase in the high frequency group compared to the low frequency group. PEP use also increased with higher HT frequency, showing a 6.129-fold (95% CI: 1.921\u201319.553, P\u2009=\u20090.002) increase in the high frequency group compared to the low frequency group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While frequent HIV testing demonstrates significant associations with increased sexual partner numbers, its role in facilitating consistent use of HIV exposure prevention prophylaxis remains clinically valuable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0358578","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:29:27Z","timestamp":1790702967000},"page":"e0358578","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the relationship between HIV Testing frequency and sexual behavior, prevention prophylaxis use among MSM in Southern China"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1948-8803","authenticated-orcid":true,"given":"Yinxia","family":"Liang","sequence":"first","affiliation":[{"name":"The Fourth People's Hospital of Nanning","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing, Guangxi Medical University","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Mo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Nursing, Guangxi Medical University","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Huang","sequence":"additional","affiliation":[{"name":"The Fourth People's Hospital of Nanning","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing, Guangxi Medical University","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Peng","sequence":"additional","affiliation":[{"name":"The Fourth People's Hospital of Nanning","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Nursing, Guangxi Medical University","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cen","sequence":"additional","affiliation":[{"name":"The Fourth People's Hospital of Nanning","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-2780","authenticated-orcid":true,"given":"Chuanyi","family":"Ning","sequence":"additional","affiliation":[{"name":"School of Nursing, Guangxi Medical University","place":["Guangxi, China"]},{"name":"Key Lab of AIDS Prevention and Treatment, Life Sciences Institute, Guangxi Medical University","place":["Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"pone.0358578.ref001","unstructured":"UNAIDS. 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