{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:13Z","timestamp":1792788613128,"version":"4.5.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Strategic Research Network in Circulation and Metabolism at Link\u00f6ping University","id":[{"id":"https:\/\/ror.org\/05ynxx418","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006129","name":"Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Primary Health Care Centres research fund, Region \u00d6sterg\u00f6tland, Sweden","award":["R\u00d6 2022\/13418"],"award-info":[{"award-number":["R\u00d6 2022\/13418"]}],"id":[{"id":"https:\/\/ror.org\/024emf479","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Liquorice, a popular confectionary product, contains several bioactive compounds. Amongst them, glycyrrhizic acid is associated with increased blood pressure, and glabridin is associated with anti-inflammatory and glucose-lowering effects. The aim was to assess the association between short term liquorice intake at a dose known to elevate blood pressure, and markers of dysglycemia, blood lipids, high-sensitivity C-reactive protein (hsCRP), and calcium metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a 2x2 crossover study, 28 healthy adults were randomized to consume liquorice or a control product in alternating 2-week periods, with measurements of blood glycated haemoglobin A\n                      <jats:sub>1c<\/jats:sub>\n                      as well as plasma glucose, calcium ion, parathyroid hormone, and lipids at the end of each period. Liquorice glabridin content was determined via LC-MSMS analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The liquorice contained 0.25\u2009\u00b1\u20090.14 \u00b5g glabridin per mg. The plasma hsCRP value increased by 32.5% (95% CI \u22129.7 to 74.6) during the intervention period vs 311.5% (95% CI \u221240.8 to 663.7) during the control period,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.045. No effects on the other markers were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Liquorice intake did not improve metabolic markers but attenuated hsCRP elevation. The potential metabolic benefits of glabridin are unlikely to outweigh the hypertensive effects when consumed as whole liquorice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0358710","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:24:48Z","timestamp":1790097888000},"page":"e0358710","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glabridin content and metabolic effects of liquorice confectionaries: A secondary analysis of a randomized crossover trial in young adults"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-7537","authenticated-orcid":true,"given":"Anna","family":"\u00c5strand","sequence":"first","affiliation":[{"name":"Link\u00f6ping University","place":["Link\u00f6ping, Sweden"],"department":["Division of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical 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