{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:44:31Z","timestamp":1792691071527,"version":"4.5.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) remains a major public health challenge, particularly in low-income countries. Previous studies conducted in Ethiopia were largely limited to single health facilities and did not adequately assess important predictors, including maternal viral load, paternal enrollment in antiretroviral therapy (ART), and breastfeeding duration. Therefore, this study aimed to determine the incidence and predictors of MTCT of HIV among HIV-exposed infants in public general hospitals of Tigray, Ethiopia\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hospital-based retrospective cohort study on 485 randomly selected HIV exposed infants attending in public General Hospitals was conducted. All HIV exposed infants attending in public general hospitals of Tigray were the source of population. Data were entered into Epidata version 4.6.1 and exported to SPSS version 23 for analysis. Binary logistic regression model was used and variables at p-value\u2009&lt;\u20090.25 in bivariate analysis were entered into a multivariable logistic regression analysis to examine the predictors of mother-to-child transmission of HIV. Level of significance was declared at p-value &lt;0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>A total of 444(91.5%) records were included in the analysis. At the end of follow up, 17 (3.8%) (95% CI: 2.3%\u20135.8%) of the HIV exposed infants became HIV positive. Poor infant adherence (AOR: 5.6; 95% CI: 1.02\u201330.2), father not enrolled to ART (AOR: 4.4; 95% CI: 1.2\u201316.7), age of infant at enrolment &gt;6 weeks (AOR: 4.4; 95% CI: 1.2\u201317.0), mothers enrolled to PMTCT during labor and delivery or after (AOR: 7.9; 95% CI: 1.4\u201344.7) and mothers on advanced WHO clinical stage at base line(AOR: 4.2; 95% CI: 1.02\u201317.89) were significantly associated with mother-to-child transmission of HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study MTCT of HIV is still high. Poor adherence of infant for PMTCT, HIV positive father not enrolled to ART, infant age\u2009&gt;\u20096 weeks at enrollment, mothers enrolled to PMTCT during labor and delivery or after and mothers on advanced WHO clinical stage were predictors of mother to child transmission of HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0358878","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:32:46Z","timestamp":1792690366000},"page":"e0358878","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and predictors of mother-to-child transmission of HIV among HIV-exposed infants in public General hospitals of Tigray, Ethiopia, 2020: Retrospective cohort study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1487-3705","authenticated-orcid":true,"given":"Gebrezgiher Gebresselassie","family":"Gerezgiher","sequence":"first","affiliation":[{"name":"Adigrat University","place":["Adigrat, Ethiopia"],"department":["Department of Nursing, College of Medicine and Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfay","family":"Gebreslassie","sequence":"additional","affiliation":[{"name":"Adigrat University","place":["Adigrat, Ethiopia"],"department":["Department of Nursing, College of Medicine and Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guesh Teklu","family":"Woldemariam","sequence":"additional","affiliation":[{"name":"Adigrat University","place":["Adigrat, Ethiopia"],"department":["Department of Nursing, College of Medicine and Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes Ashebir","family":"Tesfamicale","sequence":"additional","affiliation":[{"name":"Adigrat University","place":["Adigrat, Ethiopia"],"department":["Department of Nursing, College of Medicine and Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haftom Gebrehiwot","family":"Misgna","sequence":"additional","affiliation":[{"name":"Mekelle University","place":["Mekelle, Ethiopia"],"department":["Department of Pediatric and Child Health Nursing, School of Nursing, College of Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degena Bahrey","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Aksum University","place":["Aksum, Ethiopia"],"department":["Department of Adult Health Nursing, School of Nursing, College of Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-7450","authenticated-orcid":true,"given":"Kidane","family":"Zereabruk","sequence":"additional","affiliation":[{"name":"Aksum University","place":["Aksum, Ethiopia"],"department":["Department of Adult Health Nursing, School of Nursing, College of Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Lijalem","sequence":"additional","affiliation":[{"name":"Adigrat University","place":["Adigrat, Ethiopia"],"department":["Department of Nursing, College of Medicine and Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi","family":"Bahre","sequence":"additional","affiliation":[{"name":"Adigrat University","place":["Adigrat, Ethiopia"],"department":["Department of Nursing, College of Medicine and Health Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"pone.0358878.ref001","unstructured":"Ethipian Ministry of Health. National comprehensive HIV prevention, care and treatment training for health care providers. Participant manual; 2018."},{"issue":"8","key":"pone.0358878.ref002","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJMra1505256","article-title":"Challenges in the elimination of pediatric HIV-1 infection","volume":"374","author":"K Luzuriaga","year":"2016","journal-title":"N Engl J Med"},{"issue":"4","key":"pone.0358878.ref003","first-page":"512","article-title":"Does maternal HIV status affect infant growth?: A hospital based follow up study","volume":"2","author":"S Trivedi","year":"2012","journal-title":"Nat J Med Res"},{"key":"pone.0358878.ref004","volume-title":"Global health sector strategy on HIV 2016-2021. Towards ending AIDS","author":"World Health Organization","year":"2016"},{"key":"pone.0358878.ref005","volume-title":"Competency based national comprehensive PMTCT\/MNCH training participant\u2019s manual","author":"Federal Democratic Republic of Ethiopia Ministry of Health","year":"2017"},{"key":"pone.0358878.ref006","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev.med.050108.151127","article-title":"Growing up with HIV: Children, adolescents, and young adults with perinatally acquired HIV infection","volume":"61","author":"R Hazra","year":"2010","journal-title":"Annu Rev Med"},{"key":"pone.0358878.ref007","volume-title":"Factsheet: Global AIDS update","author":"UNAIDS U","year":"2019"},{"issue":"2","key":"pone.0358878.ref008","doi-asserted-by":"crossref","first-page":"249","DOI":"10.9745\/GHSP-D-17-00097","article-title":"Eliminating mother-to-child transmission of HIV by 2030: 5 Strategies to ensure continued progress","volume":"6","author":"AC Vrazo","year":"2018","journal-title":"Glob Health Sci Pract"},{"issue":"4","key":"pone.0358878.ref009","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jiph.2015.06.010","article-title":"Eliminating mother-to-child transmission of the human immunodeficiency virus in sub-Saharan Africa: The journey so far and what remains to be done","volume":"9","author":"OO Adetokunboh","year":"2016","journal-title":"J Infect Public Health"},{"key":"pone.0358878.ref010","volume-title":"HIV diagnosis and ARV use in HIV-exposed infants: A programmatic update","author":"WHO","year":"2018"},{"key":"pone.0358878.ref011","volume-title":"Ethiopia Demographic and Health Survey 2016","author":"Central Statistical Agency","year":"2017"},{"issue":"1","key":"pone.0358878.ref012","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12887-019-1636-y","article-title":"HIV prevalence and risk factors in infants born to HIV positive mothers, measured by dried blood spot real-time PCR assay in Tigray, Northern Ethiopia","volume":"19","author":"ML Desta","year":"2019","journal-title":"BMC Pediatr"},{"issue":"1","key":"pone.0358878.ref013","doi-asserted-by":"crossref","first-page":"1623754","DOI":"10.1080\/2331205X.2019.1623754","article-title":"Factors associated with HIV-positive sero-status among exposed infants attending care at health facilities in Bahir Dar administration, Ethiopia: Evidence from medical records","volume":"6","author":"AK Tsehay","year":"2019","journal-title":"Cogent Med"},{"key":"pone.0358878.ref014","first-page":"3262746","article-title":"Mother-to-child transmission of HIV infection and its determinants among exposed infants on care and follow-up in Dire Dawa City, Eastern Ethiopia","volume":"2016","author":"F Wudineh","year":"2016","journal-title":"AIDS Res Treat"},{"issue":"1","key":"pone.0358878.ref015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12981-024-00623-6","article-title":"Magnitude and risk factors of mother-to-child transmission of HIV among HIV-exposed infants after Option B+\u2009implementation in Ethiopia: A systematic review and meta-analysis","volume":"21","author":"W Facha","year":"2024","journal-title":"AIDS Res Ther"},{"key":"pone.0358878.ref016","first-page":"1","article-title":"HIV status and its associated factors of children born to HIV-positive mothers on ART at Gambella public hospitals, South West Ethiopia","author":"A Felege","year":"2026","journal-title":"AIDS Behav"},{"issue":"1","key":"pone.0358878.ref017","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1186\/s12879-017-2578-3","article-title":"Rate of HIV transmission and associated factors among HIV-exposed infants in selected health facilities of East and West Gojjam Zones, Northwest Ethiopia; 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HIV Prevention in Ethiopia National Road Map 2018\u20132020; 2018."},{"issue":"1","key":"pone.0358878.ref027","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/QAI.0b013e3181d8ad51","article-title":"Outcomes of HIV-exposed children in western Kenya: Efficacy of prevention of mother to child transmission in a resource-constrained setting","volume":"54","author":"WM Nyandiko","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"1","key":"pone.0358878.ref028","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4102\/ajlm.v6i1.589","article-title":"Mother-to-child transmission of HIV and its predictors among HIV-exposed infants at Bamenda Regional Hospital, Cameroon","volume":"6","author":"VN Fondoh","year":"2017","journal-title":"Afr J Lab Med"},{"issue":"1","key":"pone.0358878.ref029","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12889-017-4124-z","article-title":"Vertical HIV transmission in perinatally-exposed infants in South-Rift region of Kenya: A retrospective cross sectional study","volume":"17","author":"E Ashiono","year":"2017","journal-title":"BMC Public Health"},{"issue":"5","key":"pone.0358878.ref030","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/2325957413516495","article-title":"Health outcomes of infants in a PMTCT Program in Kinshasa","volume":"14","author":"J Ditekemena","year":"2015","journal-title":"J Int Assoc Provid AIDS Care"},{"issue":"5","key":"pone.0358878.ref031","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bjid.2015.06.006","article-title":"Effectiveness of the prevention of mother-to-child HIV transmission in Bahia, Brazil","volume":"19","author":"FRL Patricio","year":"2015","journal-title":"Braz J Infect Dis"},{"issue":"1","key":"pone.0358878.ref032","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12889-018-5024-6","article-title":"Factors associated with HIV positive sero-status among exposed infants attending care at health facilities: A cross sectional study in rural Uganda","volume":"18","author":"MM Kahungu","year":"2018","journal-title":"BMC Public Health"},{"issue":"1","key":"pone.0358878.ref033","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/s12889-019-6707-3","article-title":"Incidence, prevalence and associated factors of mother-to-child transmission of HIV, among children exposed to maternal HIV, in Belgaum district, Karnataka, India","volume":"19","author":"RS Potty","year":"2019","journal-title":"BMC Public Health"},{"key":"pone.0358878.ref034","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1186\/1756-0500-7-876","article-title":"Risk of HIV and associated factors among infants born to HIV positive women in Amhara region, Ethiopia: A facility based retrospective study","volume":"7","author":"Z Berhan","year":"2014","journal-title":"BMC Res Notes"},{"issue":"3","key":"pone.0358878.ref035","first-page":"198","article-title":"Assessment of effectiveness of prevention of mother to child transmission of human immunodeficiency virus in Asella hospital, Ethiopia","volume":"19","author":"A Mama","year":"2017","journal-title":"Eur J Clin Pharm"},{"issue":"2","key":"pone.0358878.ref036","first-page":"49","article-title":"Determinants of mother-to-child transmission of HIV despite PMTCT interventions in Enugu, Nigeria","volume":"9","author":"KK Iloh","year":"2015","journal-title":"S Afr J Child Health"},{"issue":"3","key":"pone.0358878.ref037","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1570162X1303150506182534","article-title":"Mother-to-child transmission outcomes of HIV-exposed infants followed up in Jos North-Central Nigeria","volume":"13","author":"AS Sagay","year":"2015","journal-title":"Curr HIV Res"},{"key":"pone.0358878.ref038","volume-title":"HIV diagnosis and ARV use in HIV-exposed infants: A programmatic update","author":"Organization WH","year":"2018"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0358878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:32:54Z","timestamp":1792690374000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0358878"}},"subtitle":[],"editor":[{"given":"David Chibuike","family":"Ikwuka","sequence":"first","affiliation":[{"name":"University of Rwanda College of Medicine and Health Sciences","place":["RWANDA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0358878","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]}}}