{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:00:03Z","timestamp":1790704803768,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007002","name":"Small Business Innovative Research and Small Business Technology Transfer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Objectives<\/jats:title>\n To evaluate the proof-of-concept feasibility of identifying individuals at high risk of cardiovascular disease through community-based PocDoc Healthy Heart point-of-care screening in a large, ethnically diverse, disadvantaged real-world cohort in the United Kingdom.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Proof-of-concept, non-randomised, non-interventional real-world cardiovascular disease risk case finding study in adults aged 18 years or older in real-world communities across the United Kingdom. Main outcome measures were identification of individuals with high risk of cardiovascular disease, defined as QRISK3 score \u226510%; and individuals meeting the criteria for weight loss, smoking cessation, or hypertension management services.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 4,256 individuals (mean age 49 years, 57% male, 31% body mass index \u226530 kg\/m\n 2<\/jats:sup>\n ) were included in the Primary Cohort. The Targeted Outreach and Workplace sub-cohorts comprised 1,970 and 756 individuals, respectively. In the Primary Cohort, 35% (1,486\/4,256) had high (>5.0 mmol\/L) total serum cholesterol, 10% were smokers, 10% met criteria for weight loss services and 19% met criteria for hypertension management services. QRISK3 scores were generated for individuals who had not previously had a cardiovascular disease event (~90% of screened individuals). A QRISK3 score \u226510% was found in 20% (784\/3,842) of individuals in the Primary Cohort, 26% (457\/1,743) in the Targeted Outreach sub-cohort, and 6% (41\/701) in the Workplace sub-cohort. In the Primary Cohort, 60% (472\/784) of individuals with a QRISK3 score \u226510% were not being treated with a lipid-lowering therapy at the time of testing.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this proof-of-concept study, community-based point-of-care screening identified individuals with elevated cardiovascular risk and unmet cardiovascular risk management needs. These findings are hypothesis-generating and provide the rationale for further controlled studies with systematic follow-up and health-economic analyses to evaluate whether this approach can deliver improved clinical and system-level outcomes.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n ClinicalTrials.gov\n NCT06258005<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0358999","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:32:15Z","timestamp":1790703135000},"page":"e0358999","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid community \"Healthy Heart\" screening to identify people at high risk of cardiovascular events"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-206X","authenticated-orcid":true,"given":"Kiran","family":"Roest","sequence":"first","affiliation":[{"name":"PocDoc, Vital Signs Solutions Ltd","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Kelly","sequence":"additional","affiliation":[{"name":"Health Innovation North East and North Cumbria","place":["Newcastle upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Marshall","sequence":"additional","affiliation":[{"name":"Health Innovation North East and North Cumbria","place":["Newcastle upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Whales","sequence":"additional","affiliation":[{"name":"Health Innovation North East and North Cumbria","place":["Newcastle upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Taylor","sequence":"additional","affiliation":[{"name":"Howbeck Healthcare","place":["Cheshire, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Hatfield","sequence":"additional","affiliation":[{"name":"Howbeck Healthcare","place":["Cheshire, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Bunyan","sequence":"additional","affiliation":[{"name":"PocDoc, Vital Signs Solutions Ltd","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Dawson","sequence":"additional","affiliation":[{"name":"PocDoc, Vital Signs Solutions Ltd","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Roest","sequence":"additional","affiliation":[{"name":"PocDoc, Vital Signs Solutions Ltd","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Newton","sequence":"additional","affiliation":[{"name":"Health Innovation North East and North Cumbria","place":["Newcastle upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"25","key":"pone.0358999.ref001","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.jacc.2022.11.005","article-title":"The global burden of cardiovascular diseases and risk: A compass for future health","volume":"80","author":"M Vaduganathan","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"10226","key":"pone.0358999.ref002","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0140-6736(19)32008-2","article-title":"Modifiable risk factors, cardiovascular disease, and mortality in 155\u2008722 individuals from 21 high-income, middle-income, and low-income countries (PURE): A prospective cohort study","volume":"395","author":"S Yusuf","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"pone.0358999.ref003","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-052832","article-title":"NHS Health Check programme: A rapid review update","volume":"12","author":"L Tanner","year":"2022","journal-title":"BMJ Open"},{"key":"pone.0358999.ref004","author":"England N","year":"2023"},{"issue":"20","key":"pone.0358999.ref005","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1161\/CIRCULATIONAHA.117.029652","article-title":"Socioeconomic status and cardiovascular outcomes: Challenges and interventions","volume":"137","author":"WM Schultz","year":"2018","journal-title":"Circulation"},{"key":"pone.0358999.ref006","unstructured":"Usher-Smith JA, Mant J, Martin A, Harte E, MacLure C, Meads C, et al. 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NG238","year":"2023"},{"issue":"596","key":"pone.0358999.ref010","doi-asserted-by":"crossref","DOI":"10.3399\/bjgp12X630241","article-title":"Point-of-care testing for the analysis of lipid panels: Primary care diagnostic technology update","volume":"62","author":"A Pl\u00fcddemann","year":"2012","journal-title":"Br J Gen Pract"},{"key":"pone.0358999.ref011","author":"MHRA","year":"2021"},{"key":"pone.0358999.ref012","first-page":"100504","article-title":"Smartphone-based digital point-of-care panel assay with enzymatic catalytic reaction","volume":"19","author":"KN Roest","year":"2024","journal-title":"Biosens Bioelectron: X"},{"key":"pone.0358999.ref013","article-title":"Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: Prospective cohort study","volume":"357","author":"J Hippisley-Cox","year":"2017","journal-title":"BMJ"},{"key":"pone.0358999.ref014","author":"NHS","year":"2025"},{"key":"pone.0358999.ref015","author":"NICE","year":"2019"},{"issue":"6","key":"pone.0358999.ref016","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: The Framingham Heart Study","volume":"117","author":"RB D\u2019Agostino","year":"2008","journal-title":"Circulation"},{"key":"pone.0358999.ref017","author":"NHS","year":"2025"},{"key":"pone.0358999.ref018","author":"NHS","year":"2025"},{"key":"pone.0358999.ref019","author":"M Brennan","year":"2025"},{"issue":"3","key":"pone.0358999.ref020","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-094168","article-title":"Role of community pharmacy in the prevention of cardiovascular disease in minority ethnic groups in the UK including barriers and facilitators: Protocol for a mixed methods systematic review","volume":"15","author":"RS Duley","year":"2025","journal-title":"BMJ Open"},{"issue":"12","key":"pone.0358999.ref021","article-title":"A systematic review of cardiovascular health screening in michigan: Are we doing enough?","volume":"17","author":"S Alrawi","year":"2025","journal-title":"Cureus"},{"key":"pone.0358999.ref022","author":"Office for Health Improvement & Disparities","year":"2023"},{"key":"pone.0358999.ref023","author":"NHS England"},{"issue":"24","key":"pone.0358999.ref024","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1016\/j.jacc.2016.03.528","article-title":"The effectiveness of pharmacist interventions on cardiovascular risk: The multicenter randomized controlled RxEACH trial","volume":"67","author":"RT Tsuyuki","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"pone.0358999.ref025","author":"S Waheedi","year":"2011","journal-title":"Evaluation of a community pharmacy based cardiovascular risk assessment service [PhD Thesis]. 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